Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells

American Journal of Pathology

Volumn 158, Issue 2, 2001, Pages 501-513

  Muir, David ^a   Neubauer, Debbie ^a   Lim, Ingrid T ^a   Yachnis, Anthony T ^a   Wallace, Margaret R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAMININ; NEURITE PROMOTING FACTOR; NEUROFIBROMIN;

ADOLESCENT; ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL AGING; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL TRANSPLANTATION; CHILD; CONTROLLED STUDY; EXTRACELLULAR MATRIX; HISTOGENESIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NEUROFIBROMA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; SCHWANN CELL; SCIATIC NERVE; SCID MOUSE; WESTERN BLOTTING;

EID: 0035133870     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63992-2     Document Type: Article

References (44)

1. CT imaging in adults with neurofibromatosis-1 - Frequent asymptomatic plexiform lesions
2. Cellular differentiation expression of matrix genes in type 1 neurofibromatosis
3. Peripheral nerve sheath tumors: An electron microscopic study of 43 cases
4. Cell culture studies on neurofibromatosis (von Recklinghausen). Characterization of cells growing from neurofibromas
5. The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblasts
6. Tissue culture studies of neurofibromatosis: Effects of axolemmal fragments and cyclic adenosine 3′,5′-monophosphate analogues on proliferation of Schwann-like and fibroblast-like neurofibroma cells
7. Early lesion of N-nitroso-N-ethylurea-induced hamster neurofibromatosis model
8. Cell culture studies on human nerve sheath tumors
9. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: A conceptual challenge
10. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene
11. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues
12. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
13. Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse
14. Angiogenic invasive properties of neurofibroma Schwann cells
15. Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression
16. Culture of cytogenetically abnormal Schwann cells from benign malignant NF1 tumors
17. Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma
18. Genetic cellular defects contributing to benign tumor formation in neurofibromatosis type 1
19. Selective culture of mitotically active human Schwann cells from adult sural nerves
20. Improved method for harvesting human Schwann cells from mature peripheral nerve expansion in vitro
21. Growth of a rat neuroblastoma cell line in serum-free supplemented medium
22. Metalloproteinase-dependent neurite outgrowth within a synthetic extracellular matrix is induced by nerve growth factor
23. The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2
24. Use of agarose in the determination of anchorage-independent growth
25. An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures
26. Identification of the neurofibromatosis type 1 gene product
27. Schwann cell differentiation
28. Purification and expansion of human Schwann cells in vitro
29. Distribution of merosin, a laminin-related tissue-specific basement membrane protein, in human Schwann cell neoplasms
30. The protein product of the neurofibromatosis type 1 gene is expressed at highest abundance in neurons, Schwann cells, and oligodendrocytes
31. Reduced expression of neurofibromin in the soft tissue tumours obtained from patients with neurofibromatosis type 1
32. Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I
33. Expression of the NF1 gene product in peripheral nerve sheath tumors from NF1 patients
34. Lack of NF1 expression in a sporadic schwannoma from a patient without neurofibromatosis
35. Cell-specific cyclic AMP-mediated induction of the PDGF receptor
36. Control of Schwann cell survival and proliferation: Autocrine factors and neuregulins
37. Oncogene expression in neurofibromatosis
38. Expression of the ERBB2/neu and neurofibromatosis type 1 gene products in reactive and neoplastic schwann cell proliferation
39. Cultured neonatal Schwann cells contain secrete neuregulins
40. Expression of neuregulins and their putative receptors, ErbB2, ErbB3, is induced during Wallerian degeneration
41. Glial growth factor 2, a soluble neuregulin, directly increases Schwann cell motility and indirectly promotes neurite outgrowth
42. Neurofibromatosis xenografts. Contribution to pathogenesis