Packaging signals in the 5'-ends of influenza virus PA, PB1, and PB2 genes as potential targets to develop nucleic-acid based antiviral molecules

Antiviral Research

Volumn 92, Issue 1, 2011, Pages 64-72

  Giannecchini, Simone ^a   Wise, Helen M ^b   Digard, Paul ^b   Clausi, Valeria ^a   Poggetto, Edoardo Del ^a   Vesco, Liberio ^a   Puzelli, Simona ^c   Donatelli, Isabella ^c   Azzi, Alberta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Antiviral resistance; Influenza virus; Packaging; Polymerases derived S oN; Virus inhibition

Indexed keywords

15 MER PHOSPHOROTHIOATE OLIGONUCLEOTIDE; NUCLEIC ACID; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL STRAIN; GENE FUNCTION; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; INFLUENZA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; VIRUS GENE; VIRUS GENOME; VIRUS REPLICATION; VIRUS RESISTANCE; VIRUS STRAIN; VIRUS TYPING;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DRUG RESISTANCE, MULTIPLE, VIRAL; HUMANS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MUTATION; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; RNA REPLICASE; RNA, VIRAL; VIRAL PROTEINS; VIRUS ASSEMBLY; VIRUS REPLICATION;

INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

EID: 80052825786     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.06.013     Document Type: Article

References (35)

1. Abe T., Mizuta T., Hatta T., Miyano-Kurosaki N., Fujiwara M., Takai K., Shigeta S., Yokota T., Takaku H. Antisense therapy of influenza. Eur. J. Pharm. Sci. 2001, 13:61-69.
2. Beigel J., Bray M. Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008, 78:91-102.
3. Bennett C.F., Swayze E.E. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 2010, 50:259-293.
4. Boltz D.A., Aldridge J.R., Webster R.G., Govorkova E.A. Drugs in development for influenza. Drugs 2010, 70:1349-1362.
5. Campitelli L., Mogavero E., De Marco M.A., Delogu M., Puzelli S., Frezza F., Facchini M., Chiapponi C., Foni E., Cordioli P., Webby R., Barigazzi G., Webster R.G., Donatelli I. Interspecies transmission of an H7N3 influenza virus from wild birds to intensively reared domestic poultry in Italy. Virology 2004, 323:24-36.
6. Das K., Aramini J.M., Ma L.C., Krug R.M., Arnold E. Structures of influenza A proteins and insights into antiviral drug targets. Nat. Struct. Mol. Biol. 2010, 17:530-538.
7. De Clercq E. Antiviral agents active against influenza A viruses. Nat. Rev. Drug. Discov. 2006, 5:1015-1025.
8. de Wit E., Spronken M.I., Bestebroer T.M., Rimmelzwaan G.F., Osterhaus A.D., Fouchier R.A. Efficient generation and growth of influenza virus A/PR/8/34 from eight cDNA fragments. Virus Res. 2004, 103:155-161.
9. Duan M., Zhou Z., Lin R.X., Yang J., Xia X.Z., Wang S.Q. In vitro and in vivo protection against the highly pathogenic H5N1 influenza virus by an antisense phosphorothioate oligonucleotide. Antiviral Ther. 2008, 13:109-114.
10. Gabriel G., Nordmann A., Stein D.A., Iversen P.L., Klenk H.D. Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus. J. Gen. Virol. 2008, 89:939-948.
11. Ge Q., McManus M.T., Nguyen T., Shen C.H., Sharp P.A., Eisen H.N., Chen J. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl. Acad. Sci. USA 2003, 100:2718-2723.
12. Ge Q., Pastey M., Kobasa D., Puthavathana P., Lupfer C., Bestwick R.K., Iversen P.L., Chen J., Stein D.A. Inhibition of multiple subtypes of influenza A virus in cell cultures with morpholino oligomers. Antimicrob. Agents Chemother. 2006, 50:3724-3733.
13. Giannecchini S., Campitelli L., Bandini G., Donatelli I., Azzi A. Characterization of human H1N1 influenza virus variants selected in vitro with zanamivir in the presence of sialic acid-containing molecules. Virus Res. 2007, 129:241-245.
14. Giannecchini S., Clausi V., Nosi D., Azzi A. Oligonucleotides derived from the packaging signal at the 5' end of the viral PB2 segment specifically inhibit influenza virus in vitro. Arch. Virol. 2009, 154:821-832.
15. Gog J.R., Afonso Edos S., Dalton R.M., Leclercq I., Tiley L., Elton D., von Kirchbach J.C., Naffakh N., Escriou N., Digard P. Codon conservation in the influenza A virus genome defines RNA packaging signals. Nucleic Acids Res. 2007, 35:1897-1907.
16. Hayden F.G., de Jong M.D. Emerging influenza antiviral resistance threats. J. Infect. Dis. 2011, 203:6-10.
17. Hutchinson E.C., Curran M.D., Read E.K., Gog J.R., Digard P. Mutational analysis of cis-acting RNA signals in segment 7 of influenza A virus. J. Virol. 2008, 82:11869-11879.
18. Hutchinson E.C., von Kirchbach J.C., Gog J.R., Digard P. Genome packaging in influenza A virus. J. Gen. Virol. 2010, 91:313-328.
19. Hutchinson E.C., Wise H.M., Kudryavtseva K., Curran M.D., Digard P. Characterisation of influenza A viruses with mutations in segment 5 packaging signals. Vaccine 2009, 27:6270-6275.
20. Kwok T., Helfer H., Alam M.I., Heinrich J., Pavlovic J., Moelling K. Inhibition of influenza A virus replication by short double-stranded oligodeoxynucleotides. Arch. Virol. 2009, 154:109-114.
21. Liang Y., Hong Y., Parslow T.G. cis-Acting packaging signals in the influenza virus PB1, PB2, and PA genomic RNA segments. J. Virol. 2005, 79:10348-10355.
22. Liang Y., Huang T., Ly H., Parslow T.G., Liang Y. Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments. J. Virol. 2008, 82:229-236.
23. Lyall J., Irvine R.M., Sherman A., McKinley T.J., Núñez A., Purdie A., Outtrim L., Brown I.H., Rolleston-Smith G., Sang H., Tiley L. Suppression of avian influenza transmission in genetically modified chickens. Science 2011, 331:223-226.
24. Marsh G.A., Rabadán R., Levine A.J., Palese P. Highly conserved regions of the influenza A virus polymerase gene segments are critical for efficient vRNA packaging. J. Virol. 2008, 82:2295-2304.
25. Mizuta T., Fujiwara M., Hatta T., Abe T., Miyano-Kurosaki N., Shigeta S., Yokota T., Takaku H. Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A. Nat. Biotechnol. 1999, 17:583-587.
26. Mullin A.E., Dalton R.M., Amorim M.J., Elton D., Digard P. Increased amounts of the influenza virus nucleoprotein do not promote higher levels of viral genome replication. J. Gen. Virol. 2004, 85:3689-3698.
27. Muramoto Y., Takada A., Fujii K., Noda T., Iwatsuki-Horimoto K., Watanabe S., Horimoto T., Kida H., Kawaoka Y. Hierarchy among viral RNA (vRNA) segments in their role in vRNA incorporation into influenza A virions. J. Virol. 2006, 80:2318-2325.
28. Palese P., Shaw M.L. Orthomyxoviridae: the viruses and their replication. Field Virology 2007, 1647-1690. Lippincott-Williams & Wilkins, Philadelphia, PA. fifth ed. D.M. Knipe, P.M. Howley (Eds.).
29. Reed L.J., Müench H.A. A simple method for estimating fifty percent end points. Am. J. Hyg. 1938, 27:493-497.
30. Spurgers K.B., Sharkey C.M., Warfield K.L., Bavari S. Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses. Antiviral Res. 2008, 78:26-36.
31. Tarendeau F., Boudet J., Guilligay D., Mas P.J., Bougault C.M., Boulo S., Baudin F., Ruigrok R.W., Daigle N., Ellenberg J., Cusack S., Simorre J.P., Hart D.J. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat. Struct. Mol. Biol. 2007, 14:229-233.
32. Van Aerschot A. Oligonucleotides as antivirals: dream or realistic perspective?. Antiviral Res. 2006, 71:307-316.
33. Wise H.M., Foeglein A., Sun J., Dalton R.M., Patel S., Howard W., Anderson E.C., Barclay W.S., Digard P. A complicated message: identification of a novel PB1-related protein translated from influenza A virus segment 2 mRNA. J. Virol. 2009, 83:8021-8031.
34. Zhang B., Dong H., Stein D.A., Shi P.Y. Co-selection of West Nile virus nucleotides that confer resistance to an antisense oligomer while maintaining long-distance RNA/RNA base pairings. Virology 2008, 382:98-106.
35. Zhang T., Zhao P.S., Zhang W., Liang M., Gao Y.W., Yang S.T., Wang T.C., Qin C., Wang C.Y., Xia X.Z. Antisense oligonucleotide inhibits avian influenza virus H5N1 replication by single chain antibody delivery system. Vaccine 2011, 29:1558-1564.