Enhancing complement control on endothelial barrier reduces renal post-ischemia dysfunction

Journal of Surgical Research

Volumn 170, Issue 2, 2011, Pages

  Pushpakumar, Sathnur B ^a   Perez Abadia, Gustavo ^a,c   Soni, Chirag ^a   Wan, Rong ^b   Todnem, Nathan ^a   Patibandla, Phani K ^a   Fensterer, Tathyana ^a   Zhang, Qunwei ^b   Barker, John H ^a   Maldonado, Claudio ^a,c  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c Endoprotech Inc   (United States)

Author keywords

complement; fusogenic lipid vesicles; ischemia reperfusion injury; transplantation; vaccinia virus complement control protein

Indexed keywords

COMPLEMENT COMPONENT C3; CREATININE; MYELOPEROXIDASE; RECOMBINANT PROTEIN; UREA; VACCINIA VIRUS COMPLEMENT CONTROL PROTEIN; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG DELIVERY SYSTEM; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ASSAY; FISCHER 344 RAT; HISTOPATHOLOGY; ISCHEMIA; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY ISCHEMIA; LIPID VESICLE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; UREA BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; COMPLEMENT ACTIVATION; COMPLEMENT C3; CREATININE; ENDOTHELIAL CELLS; KIDNEY DISEASES; KIDNEY FUNCTION TESTS; LIPOSOMES; MALE; NEUTROPHILS; PERMEABILITY; PEROXIDASE; RATS; RATS, INBRED F344; REPERFUSION INJURY; UREA; VIRAL PROTEINS;

EID: 80052818828     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2011.06.010     Document Type: Article

References (52)

1. C.A. Farrar, W. Zhou, and T. Lin Local extravascular pool of C3 is a determinant of postischemic acute renal failure FASEB J 20 2006 217
2. K. Yamada, T. Miwa, and J. Liu Critical protection from renal ischemia reperfusion injury by CD55 and CD59 J Immunol 172 2004 3869
3. J.M. Thurman, D. Ljubanovic, and C.L. Edelstein Lack of a functional alternative complement pathway ameliorates ischemic acute renal failure in mice J. Immunol 70 2003 1517
4. A.M. Carter, U.K. Prasad, and P.J. Grant Complement C3 and C-reactive protein in male survivors of myocardial infarction Atherosclerosis 203 2009 538
5. K. Distelmaier, C. Adlbrecht, and J. Jakowitsch Local complement activation triggers neutrophil recruitment to the site of thrombus formation in acute myocardial infarction Thromb Haemost 102 2009 564
6. A.F. Ducruet, B.E. Zacharia, and Z.L. Hickman The complement cascade as a therapeutic target in intracerebral hemorrhage Exp Neurol 219 2009 398
7. A.G. Lewis, G. Kohl, and Q. Ma Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival Clin Exp Immunol 153 2008 117
8. G.H. de, and U. Rauen Ischemia-reperfusion injury: Processes in pathogenetic networks: A review Transplant Proc 39 2007 481
9. S. Nakashima, Z. Qian, and S. Rahimi Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection J Immunol 169 2002 4620
10. T.A. Sutton, C.J. Fisher, and B.A. Molitoris Microvascular endothelial injury and dysfunction during ischemic acute renal failure Kidney Int 62 2002 1539
11. H.K. Eltzschig, and C.D. Collard Vascular ischaemia and reperfusion injury Br Med Bull 70 2004 71
12. K. Li, S.H. Sacks, and W. Zhou The relative importance of local and systemic complement production in ischaemia, transplantation and other pathologies Mol Immunol 44 2007 3866
13. S.R. Barnum Complement biosynthesis in the central nervous system Crit Rev Oral Biol Med 6 1995 132
14. J. Legoedec, P. Gasque, and J.F. Jeanne Complement classical pathway expression by human skeletal myoblasts in vitro Mol Immunol 34 1997 735
15. A.R. McPhaden, and K. Whaley Complement biosynthesis by mononuclear phagocytes Immunol Res 12 1993 213
16. Y.X. Zhao, A. Andoh, and M. Shimada Secretion of complement components of the alternative pathway (C3 and factor B) by the human alveolar type II epithelial cell line A549 Int J Mol Med 5 2000 415
17. J.M. Thurman, M.S. Lucia, and D. Ljubanovic Acute tubular necrosis is characterized by activation of the alternative pathway of complement Kidney Int 67 2005 524
18. M.J. Walport Complement. First of two parts N Engl J Med 344 2001 1058
19. M. Moller-Kristensen, W. Wang, and M. Ruseva Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury Scand J Immunol 61 2005 426
20. V.B. de, S.J. Walter, and C.J. Peutz-Kootstra The mannose-binding lectin-pathway is involved in complement activation in the course of renal ischemia-reperfusion injury Am J Pathol 165 2004 1677
21. G. Castellano, R. Melchiorre, and A. Loverre Therapeutic targeting of classical and lectin pathways of complement protects from ischemia-reperfusion- induced renal damage Am J Pathol 176 2010 1648
22. F. Lu, A.K. Chauhan, and S.M. Fernandes The effect of C1 inhibitor on intestinal ischemia and reperfusion injury Am J Physiol Gastrointest Liver Physiol 295 2008 G1042
23. K. Fattouch, G. Bianco, and G. Speziale Beneficial effects of C1 esterase inhibitor in ST-elevation myocardial infarction in patients who underwent surgical reperfusion: A randomised double-blind study Eur J Cardiothorac Surg 32 2007 326
24. C. Storini, E. Rossi, and V. Marrella C1-inhibitor protects against brain ischemia-reperfusion injury via inhibition of cell recruitment and inflammation Neurobiol Dis 19 2005 10
25. J.W. Homeister, P.S. Satoh, and K.S. Kilgore Soluble complement receptor type 1 prevents human complement-mediated damage of the rabbit isolated heart J Immunol 150 1993 1055
26. T.G. Lehmann, T.A. Koeppel, and S. Munch Impact of inhibition of complement by sCR1 on hepatic microcirculation after warm ischemia Microvasc Res 62 2001 284
27. J.R. Pratt, M.J. Hibbs, and A.J. Laver Effects of complement inhibition with soluble complement receptor-1 on vascular injury and inflammation during renal allograft rejection in the rat Am J Pathol 149 1996 2055
28. V.B. de, R.A. Matthijsen, and T.G. Wolfs Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: Inhibition of late apoptosis and inflammation Transplantation 75 2003 375
29. L. Goga, G. Perez-Abadia, and S. Pushpakumar Cell membrane modification for rapid display of bi-functional peptides: A novel approach to reduce complement activation Open Cardiovasc Med J 4 2010 157
30. P. Jablonski, B.O. Howden, and D.A. Rae An experimental model for assessment of renal recovery from warm ischemia Transplantation 35 1983 198
31. A.B. Lentsch, A. Kato, and J.T. Saari Augmented metalloproteinase activity and acute lung injury in copper-deficient rats Am J Physiol Lung Cell Mol Physiol 281 2001 L387
32. U. Sen, N. Tyagi, and M. Kumar Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells Am J Physiol Cell Physiol 293 2007 C1779
33. F. Tedesco, F. Fischetti, and M. Pausa Complement-endothelial cell interactions: Pathophysiological implications Mol Immunol 37 2000 91
34. F. Fischetti, and F. Tedesco Cross-talk between the complement system and endothelial cells in physiologic conditions and in vascular diseases Autoimmunity 39 2006 417
35. E. Moseley, M. Goddard, and S. Stoica Complement regulators are downregulated by ischemia reperfusion in heart transplantation J Heart Lung Transplantation 24 2005 S153
36. J.B. Anderson, S.A. Smith, and W.R. van Vaccinia virus complement control protein ameliorates hyperacute xenorejection by inhibiting xenoantibody binding Transplant Proc 34 2002 3277
37. N.S. Pillay, L.A. Kellaway, and G.J. Kotwal Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma Brain Res 1153 2007 158
38. D.N. Reynolds, S.A. Smith, and Y.P. Zhang Vaccinia virus complement control protein reduces inflammation and improves spinal cord integrity following spinal cord injury Ann NY Acad Sci 1035 2004 165
39. P. Jha, S.A. Smith, and D.E. Justus Prolonged retention of vaccinia virus complement control protein following IP injection: Implications in blocking xenorejection Transplant Proc. 35 2003 3160
40. Y.T. Ghebremariam, G. Engelbrecht, and M. Tyler Vaccinia virus complement control protein (VCP) improves kidney structure and function following ischemia/reperfusion injury in rats J Surg Res 159 2010 747
41. V.K. Ganesh, S.A. Smith, and G.J. Kotwal Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation Proc Natl Acad Sci USA 101 2004 8924
42. K.H. Murthy, S.A. Smith, and V.K. Ganesh Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparan sulfate proteoglycans Cell 104 2001 301
43. B.M. Brenner Nephron adaptation to renal injury or ablation Am J Physiol 249 1985 F324
44. C.N. Hales Suicide of the nephron Lancet 357 2001 136
45. S.C. Weight, P.N. Furness, and M.L. Nicholson New model of renal warm ischaemia-reperfusion injury for comparative functional, morphological and pathophysiological studies Br J Surg 85 1998 1669
46. J.R. Pratt, S.A. Basheer, and S.H. Sacks Local synthesis of complement component C3 regulates acute renal transplant rejection Nat Med 8 2002 582
47. D.G. Souza, D. Esser, and R. Bradford APT070 (Mirococept), a membrane-localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury Br J Pharmacol 145 2005 1027
48. U. Stammberger, J. Hamacher, and S. Hillinger sCR1sLe ameliorates ischemia/reperfusion injury in experimental lung transplantation J Thorac Cardiovasc Surg 120 2000 1078
49. K. Zacharowski, M. Otto, and G. Hafner Reduction of myocardial infarct size with sCR1sLe(x), an alternatively glycosylated form of human soluble complement receptor type 1 (sCR1), possessing sialyl Lewis x Br J Pharmacol 128 1999 945
50. H. Patel, R.A. Smith, and S.H. Sacks Therapeutic strategy with a membrane-localizing complement regulator to increase the number of usable donor organs after prolonged cold storage J Am Soc Nephrol 17 2006 1102
51. D. Ricklin, and J.D. Lambris Complement-targeted therapeutics Nat Biotechnol 25 2007 1265
52. L. Goga, S.B. Pushpakumar, and G. Perez-Abadia A novel liposome-based therapy to reduce complement-mediated injury in revascularized tissues J Surg Res 165 2011 e51