Determination of betamethasone in human plasma by liquid chromatography with tandem mass

Yaoxue Xuebao

Volumn 43, Issue 4, 2008, Pages 402-407

  Qu, Ting Ting ^a   Zhang, Rui ^a   Wang, Ben Jie ^a   Liu, Xiao Yan ^a   Yuan, Gui Yan ^a   Guo, Rui Chen ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Betamethasone; Compound betamethasone injection; LC MS MS; Pharmacokinetics

Indexed keywords

ANTIINFLAMMATORY AGENT; BETAMETHASONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BLOOD; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; INTRAMUSCULAR DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; MALE; METHODOLOGY; TANDEM MASS SPECTROMETRY;

ANTI-INFLAMMATORY AGENTS; AREA UNDER CURVE; BETAMETHASONE; CHROMATOGRAPHY, LIQUID; HUMANS; INJECTIONS, INTRAMUSCULAR; MALE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; YOUNG ADULT;

EID: 44649180450     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Barros GA, Marques ME, Ganem EM. The effects of intrathecal administration of betamethasone over the dogs' spinal cord and meninges [J]. Acta Cir Bras, 2007, 22: 361-365.
2. Kumar R, Verma KK, Pasricha JS. Efficacy of H, antihistamine, corticosteroids and cyclophosphamide in the treatment of chronic demographic urticaria [J]. Indian J Dermatol Venereol Leprol, 2002, 68:88-91.
3. Kamel A, Prakash C. High performance liquid chromatography/atmospheric pressure ionization/tandem mass spectrometry (HPLC/AP1/MS/MS) in drug metabolism and toxicology [J]. Curr Drug Metab, 2006, 7:837-852.
4. Higashi T. Trace determination of steroids causing age-related diseases using LC/MS combined with detection-oriented derivatization [J]. Chem Pharm Bull (Tokyo), 2006, 54:1479-1485.
5. Mazzarino M, Rossi F, Giacomelli L, et al. Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by-gas ehromatography-mass spectrometry [J]. Anal Chim Acta, 2006, 559:30-36.
6. Samtani MN, Lohle M, Grant A, et al. Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use [J]. Drug Metab Dispos, 2005, 33:1124-1130.
7. Tamvakopoulos CS, Neugebauer JM , Donnelly M, et al. Analysis of betamethasone in rat plasma using automated solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry. Determination of plasma concentrations in rat following oral and intravenous administration [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2002, 776:161-168.
8. Pereira Ados S, Oliveira LS, Mendes GD, et al. Quantification of betamethasone in human plasma by liquid chromatography-tandem mass spectrometry using atmospheric pressure photoionization in negative mode [J]. J Chromatogr B Analyt Technol Biomed Life Sci, 2005, 828:27-32.