Procalcitonin is a predictor for high-grade vesicoureteral reflux in children: Meta-analysis of individual patient data

Journal of Pediatrics

Volumn 159, Issue 4, 2011, Pages

  Leroy, Sandrine ^a,b,c   Romanello, Carla ^d   Galetto Lacour, Annick ^e   Bouissou, Franois ^f   Fernandez Lopez, Anna ^g   Smolkin, Vladislav ^h   Gurgoz, Metin K ⁱ   Bressan, Silvia ^j   Karavanaki, Kyriaki ^k   Tuerlinckx, David ^l   Leblond, Pierre ^m   Pecile, Paolo ^d   Coulais, Yvon ^f   Cubells, Carlos ^g   Halevy, Raphael ^h   Aygun, A Denizmen ⁱ   Da Dalt, Liliana ^j   Stefanidis, Constantinos J ⁿ   Borght, Thierry Vander ^l   Bigot, Sandra ^m   Dubos, Franois ^m   Gervaix, Alain ^e   Chalumeau, Martin ^b,c   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSERM   (France)

^c HÔPITAL SAINT VINCENT DE PAUL   (France)

^d UNIVERSITY OF UDINE   (Italy)

^e GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^f UNIVERSITÉ PAUL SABATIER   (France)

^g Section of Gastroenterology   (Spain)

^h HAEMEK MEDICAL CENTER   (Israel)

ⁱ FIRAT UNIVERSITY   (Turkey)

^j UNIVERSITY OF PADOVA   (Italy)

^k UNIVERSITY OF ATHENS   (Greece)

^l UNIVERSITY HOSPITAL OF MONT GODINNE   (Belgium)

^m LILLE UNIVERSITY HOSPITAL   (France)

ⁿ P AND A KYRIAKOU CHILDREN S HOSPITAL   (Greece)

more..

Author keywords

Dimercaptosuccinic acid; DMSA; PCT; Procalcitonin; Receiver operating characteristic; ROC; Urinary tract infection; UTI; Vesicoureteral reflux; VUR

Indexed keywords

C REACTIVE PROTEIN; PROCALCITONIN; SUCCIMER;

ARTICLE; CYSTOGRAPHY; DISEASE ASSOCIATION; HUMAN; KIDNEY PARENCHYMA; KIDNEY SCINTISCANNING; META ANALYSIS; MULTICENTER STUDY (TOPIC); PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; URINARY TRACT; URINARY TRACT INFECTION; VESICOURETERAL REFLUX;

EID: 80052803883     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2011.03.008     Document Type: Article

References (59)

1. N. Shaikh, N.E. Morone, J.E. Bost, and M.H. Farrell Prevalence of urinary tract infection in childhood: a meta-analysis Pediatr Infect Dis J 27 2008 302 308 (Pubitemid 351483063)
2. G. Williams, J.T. Fletcher, S.I. Alexander, and J.C. Craig Vesicoureteral reflux J Am Soc Nephrol 19 2008 847 862
3. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children Pediatrics 103 1999 843 852
4. J.R. Mackenzie, A.V. Murphy, T.J. Beattie, and A.F. Azmy Guidelines for the management of acute urinary tract infection in childhood J R Coll Physicians Lond 25 1991 263
5. M. Guillot, P. Eckart, and J.N. Dacher Initial imaging in pediatric urinary tract infection Arch Pediatr 5 1998 282-284S
6. U. Jodal, and U. Lindberg Guidelines for management of children with urinary tract infection and vesico-ureteric reflux. Recommendations from a Swedish state-of-the-art conference. Swedish Medical Research Council Acta Paediatr Suppl 88 1999 87 89
7. Groupe Suisse de Travail de Néphrologie pédiatrique Traitement des infections urinaires chez l'enfant Paediatrica 2002 Available at: http://www/swiss-paediatrica.org/paediatrica/vol12/pyelo-fr/htm
8. B. Hagglof Psychological reaction by children of various ages to hospital care and invasive procedures Acta Paediatr Suppl 88 1999 72 78
9. M. Fotakis, E. Molyvda Athanasopoulou, K. Psarrakos, and I. Economou Radiation doses to paediatric patients up to 5 years of age undergoing micturating cystourethrography examinations and its dependence on patient age: a Monte Carlo study Br J Radiol 76 2003 812 817 (Pubitemid 37479340)
10. S.M. Downs Technical report: urinary tract infections in febrile infants and young children. The Urinary Tract Subcommittee of the American Academy of Pediatrics Committee on Quality Improvement Pediatrics 103 1999 e54
11. J.P. Guignard Urinary infection after micturating cystography Lancet 1 1979 103 (Pubitemid 9089882)
12. E.H. Garin, F. Olavarria, V. Garcia Nieto, B. Valenciano, A. Campos, and L. Young Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study Pediatrics 117 2006 626 632 (Pubitemid 46063202)
13. G. Roussey-Kesler, V. Gadjos, N. Idres, B. Horen, L. Ichay, and M.D. Leclair Antibiotic prophylaxis for the prevention of recurrent urinary tract infection in children with low grade vesicoureteral reflux: results from a prospective randomized study J Urol 179 2008 674 679
14. G. Montini, L. Rigon, P. Zucchetta, F. Fregonese, A. Toffolo, and D. Gobber Prophylaxis after first febrile urinary tract infection in children? A multicenter, randomized, controlled, noninferiority trial Pediatrics 122 2008 1064 1071
15. M. Pennesi, L. Travan, L. Peratoner, A. Bordugo, A. Cattaneo, and L. Ronfani Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial Pediatrics 121 2008 e1489 e1494
16. J.M. Silva, J.S. Diniz, E.M. Lima, R.M. Vergara, and E.A. Oliveira Predictive factors of resolution of primary vesico-ureteric reflux: a multivariate analysis BJU Int 97 2006 1063 1068
17. R. Mori, M. Lakhanpaul, and K. Verrier-Jones Diagnosis and management of urinary tract infection in children: summary of NICE guidance BMJ 335 2007 395 397 (Pubitemid 47359319)
18. M.G. Coulthard NICE on childhood UTI: nasty processes produce nasty guidelines BMJ 335 2007 463 author reply 463-464 (Pubitemid 47401596)
19. U. Jodal Selective approach to diagnostic imaging of children after urinary tract infection Acta Paediatr 89 2000 767 768 (Pubitemid 30622571)
20. L. Simon, F. Gauvin, D.K. Amre, P. Saint-Louis, and J. Lacroix Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis Clin Infect Dis 39 2004 206 217 (Pubitemid 38971491)
21. S. Leroy, C. Adamsbaum, E. Marc, F. Moulin, J. Raymond, and D. Gendrel Procalcitonin as a predictor of vesicoureteral reflux in children with a first febrile urinary tract infection Pediatrics 115 2005 e706 e709
22. S. Leroy, C. Romanello, A. Galetto-Lacour, V. Smolkin, B. Korczowski, and C. Rodrigo Procalcitonin to reduce the number of unnecessary cystographies in children with a urinary tract infection: a European validation study J Pediatr 150 2007 89 95 (Pubitemid 44940884)
23. P. Pecile, E. Miorin, C. Romanello, E. Falleti, F. Valent, and F. Giacomuzzi Procalcitonin: a marker of severity of acute pyelonephritis among children Pediatrics 114 2004 e249 e254
24. C. Prat, J. Dominguez, C. Rodrigo, M. Giménez, M. Azuara, and O. Jiménez Elevated serum procalcitonin values correlate with renal scarring in children with urinary tract infection Pediatr Infect Dis J 22 2003 438 442 (Pubitemid 36578747)
25. B. Andreola, S. Bressan, S. Callegaro, A. Liverani, M. Plebani, and L. Da Dalt Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department Pediatr Infect Dis J 26 2007 672 677 (Pubitemid 47424634)
26. A.G. Guven, H.Z. Kazdal, M. Koyun, F. Aydn, F. Güngör, and S. Akman Accurate diagnosis of acute pyelonephritis: how helpful is procalcitonin? Nucl Med Commun 27 2006 715 721 (Pubitemid 44213029)
27. I. Chevalier, and M. Gauthier Procalcitonin and vesicoureteral reflux in children with urinary tract infection Pediatrics 116 2005 1261 1262 (Pubitemid 46056447)
28. Centre for Reviews and Dissemination. Systematic Reviews: CRD's guidance for undertaking reviews in health care. Available at: http://www.york.ac.uk/ inst/crd/SysRev/!SSL!/WebHelp/SysRev3.htm. Heslington, University of York; 2009. Accessed December 31, 2010
29. P. Whiting, A.W. Rutjes, J. Dinnes, J. Reitsma, P.M. Bossuyt, and J. Kleijnen Development and validation of methods for assessing the quality of diagnostic accuracy studies Health Technol Assess 8 2004 1 234
30. R.L. Lebowitz, H. Olbing, K.V. Parkkulainen, J.M. Smellie, and T.E. Tamminen-Mobius International system of radiographic grading of vesicoureteric reflux. International Reflux Study in Children Pediatr Radiol 15 1985 105 109 (Pubitemid 15198933)
31. A. Hoberman, M. Charron, R.W. Hickey, M. Baskin, D.H. Kearney, and E.R. Wald Imaging studies after a first febrile urinary tract infection in young children N Engl J Med 348 2003 195 202 (Pubitemid 36077914)
32. S. Leroy, D. Gendrel, G. Breart, and M. Chalumeau Procalcitonin and vesico-ureteral reflux in children with urinary tract infection: in reply Pediatrics 115 2005 1262 1263
33. A. Galetto-Lacour, S.A. Zamora, and A. Gervaix Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center Pediatrics 112 2003 1054 1060 (Pubitemid 37339556)
34. R. Oostenbrink, A.J. van der Heijden, K.G. Moons, and H.A. Moll Prediction of vesico-ureteric reflux in childhood urinary tract infection: a multivariate approach Acta Paediatr 89 2000 806 810 (Pubitemid 30622580)
35. N. Benador, C.A. Siegrist, D. Gendrel, C. Greder, D. Benador, and M. Assicot Procalcitonin is a marker of severity of renal lesions in pyelonephritis Pediatrics 102 1998 1422 1425 (Pubitemid 28550836)
36. P. Royston, D.G. Altman, and W. Sauerbrei Dichotomizing continuous predictors in multiple regression: a bad idea Stat Med 25 2006 127 141 (Pubitemid 43136953)
37. Altman DG, Machin D, Bryant TN, Gardner MJ, editors. Statistics with confidence. London, UK: BMJ 2000.
38. E. Mantadakis, E. Plessa, E.K. Vouloumanou, D.E. Karageorgopoulos, A. Chatzimichael, and M.E. Falagas Serum procalcitonin for prediction of renal parenchymal involvement in children with urinary tract infections: a meta-analysis of prospective clinical studies J Pediatr 155 2009 875 881
39. F. Song, K.S. Khan, J. Dinnes, and A.J. Sutton Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy Int J Epidemiol 31 2002 88 95 (Pubitemid 34284907)
40. J.J. Deeks, P. Macaskill, and L. Irwig The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed J Clin Epidemiol 58 2005 882 893 (Pubitemid 41115772)
41. L.A. Stewart, and M.K. Parmar Meta-analysis of the literature or of individual patient data: is there a difference? Lancet 341 1993 418 422 (Pubitemid 23048157)
42. E. Vittinghoff, and C.E. McCulloch Relaxing the rule of ten events per variable in logistic and Cox regression Am J Epidemiol 165 2007 710 718 (Pubitemid 46348374)
43. K. Nakanishi, and N. Yoshikawa Genetic disorders of human congenital anomalies of the kidney and urinary tract (CAKUT) Pediatr Int 45 2003 610 616 (Pubitemid 37430772)
44. S. Sjostrom, U. Sillen, M. Bachelard, S. Hansson, and E. Stokland Spontaneous resolution of high grade infantile vesicoureteral reflux J Urol 172 2004 694 699
45. Leroy, S. Vantalon, A. Larakeb, H. Ducou-Le-Pointe, and A. Bensman Comparison of diagnostic accuracy of renal ultrasonography criteria for vesico-ureteral reflux in children with urinary tract infection Radiology 255 2010 890 898
46. B. Andreola, S. Bressan, S. Callegaro, A. Liverani, M. Plebani, and L. Da Dalt Procalcitonin and C-reactive protein as diagnostic markers of severe bacterial infections in febrile infants and children in the emergency department Pediatr Infect Dis J 26 2007 672 677 (Pubitemid 47424634)
47. H. Belhadj-Tahar, Y. Coulais, M. Tafani, and F. Bouissou Procalcitonin implication in renal cell apoptosis induced by acute pyelonephritis in children Infect Drug Resist 1 2008 17 20
48. S. Bigot, P. Leblond, C. Foucher, V. Hue, M. D'Herbomez, and M. Foulard Usefulness of procalcitonin for the diagnosis of acute pyelonephritis in children Arch Pediatr 12 2005 1075 1080 (Pubitemid 40835223)
49. A. Fernández López, C. Luaces Cubells, C. Valls Tolosa, Rodríguez J. Ortega, García J.J. García, and Vallet A. Mira Procalcitonin in the early diagnosis of invasive bacterial infection in febrile infants An Esp Pediatr 55 2001 321 328
50. A. Fernandez Lopez, C. Luaces Cubells, J.J. Garcia Garcia, and J. Fernandez Pou Procalcitonin in pediatric emergency departments for the early diagnosis of invasive bacterial infections in febrile infants: results of a multicenter study and utility of a rapid qualitative test for this marker Pediatr Infect Dis J 22 2003 895 903 (Pubitemid 37288613)
51. A. Galetto-Lacour, S.A. Zamora, and A. Gervaix Bedside procalcitonin and C-reactive protein tests in children with fever without localizing signs of infection seen in a referral center Pediatrics 112 2003 1054 1060 (Pubitemid 37339556)
52. A. Gervaix, A. Galetto-Lacour, T. Gueron, L. Vadas, S. Zamora, and S. Suter Usefulness of procalcitonin and C-reactive protein rapid tests for the management of children with urinary tract infection Pediatr Infect Dis J 20 2001 507 511 (Pubitemid 32428909)
53. M.K. Gurgoze, S. Akarsu, E. Yilmaz, A. Gödekmerdan, Z. Aka, and I. Cifti Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis Pediatr Nephrol 20 2005 1445 1448 (Pubitemid 41403421)
54. P. Pecile, E. Miorin, C. Romanello, E. Falleti, F. Valent, and F. Giacomuzzi Procalcitonin: a marker of severity of acute pyelonephritis among children Pediatrics 114 2004 e249 e254
55. V. Smolkin, A. Koren, R. Raz, R. Colodner, W. Sakran, and R. Halevy Procalcitonin as a marker of acute pyelonephritis in infants and children Pediatr Nephrol 17 2002 409 412 (Pubitemid 36067988)
56. K. Karavanaki, F.A. Haliotis, M. Sourani, C. Kariyiannis, E. Hantzi, and L. Zachariadou DMSA scintigraphy in febrile urinary tract infections could be omitted in children with low procalcitonin levels Infect Dis Clin Pract 15 2007 377 381 (Pubitemid 350135450)
57. D. Tuerlinckx, T. Vander Borght, Y. Glupczynski, L. Galanti, V. Roelants, and B. Krug Is procalcitonin a good marker of renal lesions in febrile urinary tract infection? Eur J Pediatr 164 2005 651 652 (Pubitemid 41428256)
58. A.T. Kotoula, S. Gardikis, A. Tsalkidis, E. Mantadakis, A. Zissimopoulos, and S. Deftereos Comparative efficacies of procalcitonin and conventional inflammatory markers for prediction of renal parenchymal inflammation in pediatric first urinary tract infection Urology 73 2009 782 786
59. A.G. Guven, H.Z. Kazdal, M. Koyun, F. Aydn, F. Güngör, and S. Akman Accurate diagnosis of acute pyelonephritis: How helpful is procalcitonin? Nucl Med Commun 27 2006 715 721 (Pubitemid 44213029)