Human motor neuron progenitor transplantation leads to endogenous neuronal sparing in 3 models of motor neuron loss

Stem Cells International

Volumn , Issue , 2011, Pages

  Wyatt, Tanya J ^a   Rossi, Sharyn L ^a   Siegenthaler, Monica M ^b   Frame, Jennifer ^a   Robles, Rockelle ^a   Nistor, Gabriel ^b   Keirstead, Hans S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b California Stem Cell Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE ACETYLTRANSFERASE; NERVE GROWTH FACTOR; NEURON SPECIFIC NUCLEAR PROTEIN; NEUROTROPIN; NEUROTROPIN 3; PROTEIN P75; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYONIC STEM CELL; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOTONEURON; MOTOR NEURON PROGENITOR TRANSPLANTATION; MOUSE; NERVE CELL DIFFERENTIATION; NEUROTROPISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; SPINAL CORD INJURY; SPINAL MUSCULAR ATROPHY; STEM CELL TRANSPLANTATION;

ANIMALIA; RODENTIA;

EID: 80052771028     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.4061/2011/207230     Document Type: Article

References (26)

1. Mackenzie I. R. A., Rademakers R., Neumann M., TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia The Lancet Neurology 2010 9 10 995 1007
2. Lepore A. C., Rauck B., Dejea C., Pardo A. C., Rao M. S., Rothstein J. D., Maragakis N. J., Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease Nature Neuroscience 2008 11 11 1294 1301
3. Di Giorgio F. P., Boulting G. L., Bobrowicz S., Eggan K. C., Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation Cell Stem Cell 2008 3 6 637 648
4. Rothstein J. D., Current hypotheses for the underlying biology of amyotrophic lateral sclerosis Annals of Neurology 2009 65 1 S3 S9
5. Lobsiger C. S., Boillee S., McAlonis-Downes M., Khan A. M., Feltri M. L., Yamanaka K., Cleveland D. W., Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice Proceedings of the National Academy of Sciences of the United States of America 2009 106 11 4465 4470
6. Mitchell J., Borasio G., Amyotrophic lateral sclerosis The Lancet 2007 369 9578 2031 2041 (Pubitemid 46899183)
7. Dormann D., Rodde R., Edbauer D., Bentmann E., Fischer I., Hruscha A., Than M. E., Mackenzie I. R. A., Capell A., Schmid B., Neumann M., Haass C., ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import The EMBO Journal 2010 29 16 2841 2857
8. Feldktter M., Schwarzer V., Wirth R., Wienker T. F., Wirth B., Quantitative analyses of SMN1 and SMN2 based on real-time lightcycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy American Journal of Human Genetics 2002 70 2 358 368 (Pubitemid 34112291)
9. Wyatt T. J., Keirstead H. S., Stem cell-derived neurotrophic support for the neuromuscular junction in spinal muscular atrophy Expert Opinion on Biological Therapy 2010 10 11 1587 1594
10. Bumer D., Lee S., Nicholson G., Davies J. L., Parkinson N. J., Murray L. M., Gillingwater T. H., Ansorge O., Davies K. E., Talbot K., Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy PLoS Genetics 2009 5 12
11. Lefebvre S., Brglen L., Reboullet S., Clermont O., Burlet P., Viollet L., Benichou B., Cruaud C., Millasseau P., Zeviani M., Le Paslier D., Frézal J., Cohen D., Weissenbach J., Munnich A., Melki J., Identification and characterization of a spinal muscular atrophy-determining gene Cell 1995 80 1 155 165
12. Sharp J., Frame J., Siegenthaler M., Nistor G., Keirstead H. S., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury Stem Cells 2010 28 1 152 163
13. Einstein O., Ben-Hur T., The changing face of neural stem cell therapy in neurologic diseases Archives of Neurology 2008 65 4 452 456 (Pubitemid 351549952)
14. Lu P., Jones L. L., Snyder E. Y., Tuszynski M. H., Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injury Experimental Neurology 2003 181 2 115 129 (Pubitemid 36629234)
15. Ben-Hur T., Reconstructing neural circuits using transplanted neural stem cells in the injured spinal cord Journal of Clinical Investigation 2010 120 9 3096 3098
16. Bregman B. S., McAtee M., Dai H. N., Kuhn P. L., Neurotrophic factors increase axonal growth after spinal cord injury and transplantation in the adult rat Experimental Neurology 1997 148 2 475 494 (Pubitemid 28068843)
17. Martin D., Robe P., Franzen R., Delrée P., Schoenen J., Stevenaert A., Moonen G., Effects of Schwann cell transplantation in a contusion model of rat spinal cord injury Journal of Neuroscience Research 1996 45 5 588 597 (Pubitemid 26293359)
18. Cloutier F., Siegenthaler M. M., Nistor G., Keirstead H. S., Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm Regenerative Medicine 2006 1 4 469 479
19. Bjrklund A., Lindvall O., Cell replacement therapies for central nervous system disorders Nature Neuroscience 2000 3 6 537 544 (Pubitemid 30332071)
20. Rossi S. L., Nistor G., Wyatt T., Yin H. Z., Poole A. J., Weiss J. H., Gardener M. J., Dijkstra S., Fischer D. F., Keirstead H. S., Histological and functional benefit following transplantation of motor neuron progenitors to the injured rat spinal cord PLoS ONE 2010 5 7
21. Zhang Y. W., Denham J., Thies R. S., Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors Stem Cells and Development 2006 15 6 943 952 (Pubitemid 46147864)
22. Keirstead H. S., Nistor G., Bernal G., Totoiu M., Cloutier F., Sharp K., Steward O., Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury Journal of Neuroscience 2005 25 19 4694 4705 (Pubitemid 40664118)
23. Taylor A. M., Blurton-Jones M., Rhee S. W., Cribbs D. H., Cotman C. W., Jeon N. L., A microfluidic culture platform for CNS axonal injury, regeneration and transport Nature Methods 2005 2 8 599 605 (Pubitemid 41086851)
24. Corti S., Nizzardo M., Nardini M., Donadoni C., Salani S., Del Bo R., Papadimitriou D., Locatelli F., Mezzina N., Gianni F., Bresolin N., Comi G. P., Motoneuron transplantation rescues the phenotype of SMARD1 (Spinal Muscular Atrophy with Respiratory Distress type 1) Journal of Neuroscience 2009 29 38 11761 11771
25. Riley C. P., Cope T. C., Buck C. R., CNS neurotrophins are biologically active and expressed by multiple cell types Journal of Molecular Histology 2004 35 8-9 771 783 (Pubitemid 41404623)
26. Tuszynski M. H., Gabriel K., Gage F. H., Suhr S., Meyer S., Rosetti A., Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury Experimental Neurology 1996 137 1 157 173 (Pubitemid 26041792)