The role of trace elements on hepatitis virus infections: A review

Journal of Trace Elements in Medicine and Biology

Volumn 25, Issue 3, 2011, Pages 181-187

  Rashed, Mohamed Nageeb ^a  

^a ASWAN UNIVERSITY   (Egypt)

Author keywords

Antioxidants; Biology; HBV; HCV; Trace elements, hepatitis

Indexed keywords

ANTIOXIDANT; COBALT; COPPER; IRON; LEAD; MANGANESE; RECOMBINANT ALPHA INTERFERON; RECOMBINANT ALPHA2B INTERFERON; TRACE ELEMENT; ZINC;

ARTICLE; BLOOD LEVEL; COPPER BLOOD LEVEL; COPPER DEFICIENCY; COPPER METABOLISM; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DRUG RESPONSE; ENVIRONMENTAL EXPOSURE; FOOD INTAKE; HEPATIC ENCEPHALOPATHY; HEPATITIS A; HEPATITIS B; HEPATITIS C; HUMAN; IRON DEFICIENCY; LEAD BLOOD LEVEL; LEAD POISONING; LIVER DISEASE; LIVER LEVEL; METAL METABOLISM; NONHUMAN; NUTRIGENOMICS; NUTRITIONAL STATUS; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; TRACE METAL BLOOD LEVEL; VIRUS HEPATITIS; VIRUS REPLICATION; ZINC BLOOD LEVEL; ZINC DEFICIENCY; ZINC METABOLISM;

ANIMALS; ANTIOXIDANTS; HEPATITIS; HEPATITIS VIRUSES; HUMANS; TRACE ELEMENTS;

HEPATITIS B VIRUS; HEPATITIS C VIRUS;

EID: 80052766444     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2011.07.001     Document Type: Article

References (85)

1. Nakayama A., Fukuda H., Ebara M., Hamasaki H., Nakajima K., Sakurai H. A new diagnostic method for chronic hepatitis, liver cirrhosis and hepatocellular carcinoma based on serum metallothionein, copper and zinc levels. Biol Pharm Bull 2002, 25(4.):426-431.
2. Rukgauer M., Neugebauer R.J., Plecko T. The relation between selenium, zinc and copper concentration and the trace element dependent antioxidative status. J Trace Elem Med Biol 2001, 15:73-78.
3. Konukoglu D., Ercan M., Ayaz M., Onen S. Plasma and erythrocytes antioxidant status and trace element level in proteinuric patients with moderate glomerular function. J Trace Elem Med Biol 2001, 15:119-122.
4. Rostan E.F., DeBuys H.V., Madey D.L., Pinnell S.R. Evidence supporting zinc as a important antioxidant for skin. Int J Dermatol 2002, 41:606-611.
5. Maret W. Cellular zinc and redox states converge in the metallothionein/thionein pair. J Nutr (Suppl) 2003, 133(4625):1460-1461.
6. Cesur S., Cebeci S.A., Kavas G.O., Aksaray S., Tezeren D. (Serum copper and zinc concentrations in patients with chronic hepatitis B. J Infect 2005, 51:38-40.
7. Sandstead H.H. Understanding zinc: recent observations and interpretations. J Lab Clin Med 1994, 124:322-327.
8. Prasad A.S. Zinc: an overview. Nutrition 1995, 11:93-99.
9. Prasad A.S., Beck F.W., Grabowski S.M., Kaplan J., Mathog R.H. Zinc deficiency: changes in cytokine production and T-cell subpopulations in patients with head and neck cancer and in noncancer subjects. Proc Assoc Am Physicians 1997, 109:68-77.
10. Solomons N.W. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr Rev 1998, 26:27-28.
11. Hambidge K.M. Mild zinc deficiency in human subjects in zinc in human biology 1989, 281-296. Springer-Verlag, New York.
12. Prasad A.S. Zinc deficiency in women, infants and children. J Am Coll Nutr 1996, 15:113-120.
13. King J.C., Keen C.L. Zinc in Modern Nutrition in Health and Disease 1999, Williams &Wilkins, Baltimore, pp. 223-239. 9th ed.
14. Gur G., Bayraktar Y., Ozer D., Ozdogan N., Kayhan B. Determination of hepatic zinc content in chronic liver disease due to hepatitis B virus. Hepatogasteroenterology 1998, 45:472-476.
15. Shankar A.H., Prasad A.S. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998, 68:447s-463s.
16. Chaturvedi U.C., Shrivastava R., Upreti R.K. Viral infections and trace elements: a complex interaction. Curr Sci 2004, 87(11):1536-1554.
17. Anderson D.A., Locarnini S.A., Ross B.C., Coulepis A.G., Anderson B.N., Gust I.D. Single cycle growth kinetics of hepatitis a virus in BSc.1 cells. Positive strand RNA viruses 1987, vol. 49:7-507. Alan, R. Liss, New York.
18. Bishop N.E., Anderson D.A. Early interactions of hepatitis a virus with cultured cells: viral elution and the effect of pH and calcium ions. Arch Virol 1997, 142:2161-2178.
19. Fota-Markowska H., Przybyla A., Borowicz I., Modzewska R. Serum zinc (Zn) level dynamics in blood serum of patients with acute viral hepatitis B and early period. Ann Univ Mariae Curie-Sklodowska [Med] 2002, 57:201-209.
20. Ozbal E., Helvaci M., Kasirga E., Akdenizoglu F., Kizilgunester A. Serum zinc as a factor predicting response to interferon-alpha 2b therapy in children with chronic hepatitis B. Biol Trace Elem Res 2002, 90:31-38.
21. Selimoglu M.A., Aydogdu S., Unal F., Yuce G., Yagei R.V. Serum zinc status in chronic hepatitis B and its relationship to liver histology. Pediatr Int 2001, 43:396-399.
22. Nagamine Nagamine T. The possible role of zinc and metallothionein in the liver in the therapeutic effect of IFN-alpha to hepatitis C patients. Biol Trace Elem Res 1997, 58:65-76.
23. Takagi H. Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C. J Viral Hepat 2001, 8:367-371.
24. Minhe, L.; Huimin, J.; Baiquan, X.; Xi C. and Zhengxiang, X. Relationship between viral heptatitis and four trace elements in sera. Varian Instruments at Work Number AA-89, China, 1989.
25. Kalkan A., Bulut V., Avci S., Celik I., Bingol N.K. Trace elements in viral hepatitis. J Trace Elem Med Biol 2002, 16:227-230.
26. Versieck J., Barbier F., Speeke A., Hoste J. Mangaese, copper and zinc concentrations in serum and packed blood cells during acute hepatitis, chronic hepatitis, and posthepatitic cirrhosis. Clin Chem 1974, 20(9):1141-1145.
27. Rashed M.N., Mahasen Mohamed Ahmed, Ahmed Farouk Al-Hossainy, Safaa Mahmoud Trends in speciation analysis of some heavy metals in serum of patients with chronic hepatitis C and chronic hepatitis B using differential pulse adsorptivestripping voltammetric measurement and atomic absorption spectrophotometry. J Trace Elem Med Biol 2010, 24:138-145.
28. Pramoolsinsap C., Promvanit N., Komindr S., Lerdverasirikul P., Srianujata S. Serum trace metals in chronic viral hepatitis and hepatocellular carcinoma in Thailand. J Gastroenterol 1994, 29:610-615.
29. Pramoolsinsap C., Promvanit N., Kurathongs S. Serum trace metal levels in patients with acute hepatitis B. Southeast Asian J Trop Med Public Health 1996, 27:476-480.
30. Teles-Martos C., Navarro-Alareon M., Martin-Logos F. Serum zinc and copper concentrations and Cu/Zn ratios in patients with hepatopathies or diabetes. J Trace Elem Med Biol 1998, 12:44-49.
31. Yildirmak T., Eren S., Eroglu N., Alpagut S., Akut B. Hepatitinde ve asemptomatik Hbs Ag tasiyicilarda plasma ve eritrosit cinko düzeyleri, 111, ulusal viral hepatit sempozynma, 7-9 kasim 1996 1996, Congress Book, Ankara, p. 33.
32. LCC, Contact colloids for life Hepatitis C and Iron, USA, 2006, http://www.silver.4life.com/.
33. Gaetke L.M., Chow C.K. Copper toxicity oxidative stress and antioxidant nutrients. Toxicology 2003, 189:147-163.
34. CMRS Chelation Site. J Clin Pharmacol 1998, 38:101-105.
35. Tanasescu C., Baldescu R., Chirulescu Z. Interdependence between Zn and Cu serum concentrations and serum immunoglobulins in liver diseases. Rom J Int Med 1996, 34:217-224.
36. Hatono R., Ebara M., Fukuda H., Yoshikawa M., Sugiura N., Kondo F., et al. Accumulation of copper in the liver and hepatic injury in chronic hepatitis C. J Gastroenterol Hepatol 2000, 15(7):786-791.
37. Ko W.-S., Guo C.-H., Hsu G.-S.W., Chiou Y.-L., Yeh M.-S., Yaun S.-R. The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin. Clin Biochem 2005, 38(7):614.
38. Nozdrin-Plothicki B., Jankowski A. Activity of cobalt activated acylase and Australia antigen (HbAg) in children suffering from viral hepatitis. Arch Immunol Ther Exp (Warsz) 1976, 24:433-437.
39. Hunt A.H., Parr R.M., Taylor D.M., Trott N.G. Relationship between cirrhosis and trace metal content of liver special reference to primary biliary cirrhosis and copper. Br Med J 1976, 14(2(5371)):1498-1501.
40. Irnius A., Speieiene D., Pajenekovskyte K., Tautkus S., Kazlauskas R., Kareiva A. Rapid quantitative determination of metals in blood and liver by FAAS. Chemistry 2005, 16(3-4):29-33.
41. Urban M., McMillan D.J., Canning G., Newell A., Brown E., Mills J.S., et al. In vitro activity of hepatitis B virus polymerase: requirement for distinct metal ions and the viral epsilon stem-loop. J Gem Virol 1998, 79:1121-1131.
42. Sullivan J.F., Blotcky A.J., Jetton M.M., Halin H.K.J., Burch R.E. Serum levels of selenium, calcium, copper, manganese, magnesium and zinc in various human diseases. J Nutr 1979, 109:1432-1437.
43. Bassett S.E., Di Bisceglic A.M., Bacon B.R., Sharp R.M., Govindarajan S., Hubbard G.B., et al. Effects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees. Hepatology 1999, 29:1884-1892.
44. Wald MB. Natural Approaches for Hepatitis C, Part XIII Advanced Medicine of Mount Kisco, 2002.
45. Somi M.H., Rahimi A.O., Moshrefi B., Rezaeifar P., Maghami J.G. Nutritional status and blood trace elements in cirrholic patients. Hepatitis Mon 2007, 7(1):27-32.
46. Dibisceglie A.M., Axiolis C.A., Hoofinagle J.H., Bacon B.R. Measurements of iron status in patients with chronic hepatitis. Gastroenterology 1992, 102:2108-2113.
47. Riggio O., Montagnese F., Fiore P., Folino S., Giambartolomei S., Gandin C. Iron overload in patients with chronic viral hepatitis. How common is it. Am J Gastroenterol 1997, 92:1298-1301.
48. Kakizaki S., Takagi H., Horiguchi N., Toyoda M., Takayama H., Nagamine T., et al. Iron enhances hepatitis C virus replication in cultured human hepatocytes. Liver Int 2000, 20:125-128.
49. Nelson J.E., Kowdley K.V. Iron and hepatitis C. J Curr Hepatitis 2004, 3(4):140-147.
50. Bonkovsky H.L., Troy N., Mc Neal K. Iron or TFRI mutations as comorbid factors for development and progression of chronic hepatitis C. Hepatology 2002, 37:848-854.
51. Barton A.L., Banner B.F., Cable E.E., Bonkovsky H.L. Distribution of iron in the liver predicts the response of chronic hepatitis C infection to interferon therapy. Am J Clin Pathol 1995, 103:419-424.
52. Fargion S., Fracanzani A.L., Rossini A. Iron reduction and sustained response to interferon-alpha therapy in patients with chronic hepatitis C: results of an Italian multicenter randomized study. Am J Gastroenterol 2002, 97:1204-1210.
53. Van Weyenbergh J., Santana G., Doliverira A.J., Santos A.F., Costa C.H., Carvalho E.M., et al. M. Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study. BMC Infect Dis 2004, 4:50.
54. Ikura Y., Morimoto H., Johmura H., Fukui M., Sakurai M. Relationship between hepatic iron deposits and response to interferon in chronic hepatitis C. Am J Gastroenterol 1996, 91:1367-1373.
55. Piperno A., Sampietro M., D'Alba R., Roffi L., Fargion S. and Parma, Iron stores, response to interferon therapy and effect of iron elepletion in chronic hepatitis C. Liver Int 1996, 16:248-254.
56. Fontana R.J., Israel J., Leclair P. Iron reduction before and during interferon therapy of chronic hepatitis C: results of a multi center, randomized, controlled trial. Hepatology 2000, 31:730-736.
57. Sartori M., Andorno S., Rigamonti C., Boldorin R. Chronic hepatitis C treated with phlebotomy alone: biochemical and histological outcome. Dig Liver Dis 2001, 33(15):7-62.
58. Yano M., Hayashi H., Wakusawa S. Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C. Am J Gastroenterol 2002, 97:133-137.
59. Shedlofsky S.I. Does iron reduction improve sustained viral responses to interferon monotherapy in hepatitis C patients? May be but is the right question?. Am J Gastroenterol 2002, 97:1093-1096.
60. Fabric C., Toniutto P., Scott C.A. Serum iron indices as a measure of iron deposits in chronic hepatitis C. Clin Chim Acta 2001, 304:49-55.
61. Hofer H., Osterreicher C., Jessner W. Hepatic iron concentra-tion does not predict response to standard and pegylated IFN/ribavirin therapy in patients with chronic hepatitis C. J Hepatol 2004, 40:1018-1022.
62. Kazemi-Shirazi L., Datz C., Maier-Dobersberger T. The relation of iron status and hemochromatosis gene, mutations in patients with chronic with chronic hepatitis C. Gastroenterology 1999, 116:127-224.
63. Metwally M.A., Zein C.O., Zein N.N. Clinical significance of hepatic iron deposition and serum iron values in patients with chronic hepatitis C infection. Am J Gastroenterol 2004, 99:286-291.
64. Marcellin P., Asselah T., Boyer N. Fibrosis and disease progression hepatitis C. Hepatology 2002, 1:47-56.
65. Lin T.J., Liao L.Y., Lin S.Y., Chang T.A. Influnce of iron on the severity of hepatic fibrosis in patients with chronic hepatitis C. J Gastroenterol 2006, 12(30):4897-4901.
66. Geier A., Reugels M., Weiskirchen R. Common heterozygous hemochromatosis gene mutions are risk factors for inflammation and fibrosis in chronic hepatitis C. Liver Int 2004, 24:285-294.
67. Eisenbach C., Gehrke S.G., Stremmel W. Iron, the HFE gene and hepatitis C. Clin Liver Dis 2004, 8:775-785.
68. Barbaro G., Di Lorenzo G., Ribersani G. Serum ferritin and hepatic glutathione concentrations in chronic hepatitis C patients related to the hepatitis C virus genotype. J Hepatol 1999, 30:774-782.
69. Tung B.Y., Kowdley K.V. Hepatitis C, iron status and disease severity: relationship with HFE mutations. Gastroenterology 2003, 124:318-326.
70. Gehrke S.G., Wolfgang S., Inge M., Hans-Dieter R., Karin B., Birgit K. Hemochromatosis and transferring receptor gene polymorphisms in chronic hepatitis C: impact on iron statues, liver injury and HCV genotype. J Mol Med 2003, 81:780-787.
71. Lebray P., Zylberberg H., Hue S., Carnot F., Martin S., Chretien Y., et al. Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C. J Viral Hepat 2004, 11:175-182.
72. Martinelli A.L.C., Franco R.F., Villanova M.G. Are haemochro-matosis mutations related to the severity of liver disease in hepatitis C virus infections?. Acta Haematal 2000, 102:152-156.
73. Shan Y., Lambrecht R.W., Bonkovsky H.L. Association of hepatitis C virus infection with serum iron status: Analysis of data from the third national health and nutrition examination survey. Clin Infect Dis 2005, 5(40):834-841.
74. Blumberg G.S., Lustbader E.D., Whitford G.L. Changes in iron serum levels due to infection with hepatitis B virus. Proc Natl Acad Sci USA 1981, 78:3222-3224.
75. Lustbader E.D., Hann H.L., Blumberg G.S. Serum ferritin as a predictor of host response to hepatitis B virus infection. Science 1983, 220:423-425.
76. Hengeveld P., Zuyderhoudt F.M.J., Jobsis A.G., Vangool J. Some aspects of iron metabolism during acute viral hepatitis. Hepatogastroenterology 1982, 29:138-141.
77. Deugnier Y., Battistelli D., Jouanolle H. Hepatitis B virus infection markers in genetic haemochromatosis. A study of 272 patients. J Hepatol 1992, 13:286-290.
78. Zhou X., Detolla L., Custer P., London W.T. Ironferritin, hepatitis B surface and core antigens in the livers of Chinese patients with hepatocellular carcinoma. Cancer 1987, 59:1430-1437.
79. Chrobot A., Chrobot A.M., Szaflarska-Szczepanik A. Assesment of iron metabolism in children with chronic hepatitis B-prognostic factor in interferon alpha therapy. Med Sci Monit 2002, 8(4):269-273.
80. Rubin R.B., Barton A.L., Banner B.F., Bonkovsky H.L. Iron and chronic viral hepatitis: emerging evidence for an important interaction. Dig Dis 1995, 13:223-238.
81. Roberts J.R. Metal toxicity in children. In training manual on pediatric environmental health: putting it into practice 1999 June, Children's Environmental Health Network, Emeryville, CA, http://www.Cehn.org/cehn/trainingmanual/pdf/manualfull.pbf.
82. Bortoli A., Mattiello G., Zotti S., Bonvicini P., Trabuio G., Fezzin G. Blood lead levels in patients with chronic liver diseases. Int Arch Occup Environ Health 1983, 52(1):49-57.
83. Castilla L., Castro M., Grilo A., Guerrero P., Lopez-Artiquez M., Soria M.L., et al. Hepatic and blood lead levels in patients with chronic liver disease. Eur J Gastrroentrol Hepatol 1995, 7(3):243-249.
84. Khurshid J.S., Iqbal H.Q. The role of inorganic elements in the human body. Nucleus 1984, 21:3-23.
85. Khan M.H., Qayyum K. Deterination of trace amounts of iron, copper, nickel, cadmium and lead in human blood by atomic absorption spectrometry. Pak J Biol Sci 2002, 5(10):1104-1107.