A case of severe thrombotic thrombocytopenic purpura with concomitant legionella pneumonia: Review of pathogenesis and treatment

American Journal of Therapeutics

Volumn 18, Issue 5, 2011, Pages

  Talebi, Tony ^a   Fernandez Castro, Gustavo ^a   Montero, Alberto J ^a   Stefanovic, Alexandra ^a   Lian, Eric ^a  

^a UNIVERSITY OF MIAMI   (United States)

Author keywords

ADAMTS13; cryosupernant plasma; hemolytic uremic syndrome; legionella; plasma exchange; thrombocytopenia; thrombotic thrombocytopenic purpura

Indexed keywords

ANTIBIOTIC AGENT; LEVOFLOXACIN; METHYLPREDNISOLONE; STEROID; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

AGED; ANAMNESIS; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; HUMAN; LEGIONNAIRE DISEASE; MALE; PATHOGENESIS; PLASMAPHERESIS; PNEUMONIA; PRIORITY JOURNAL; REVIEW; THORAX RADIOGRAPHY; THROMBOTIC THROMBOCYTOPENIC PURPURA;

AGED; ANTI-BACTERIAL AGENTS; GLUCOCORTICOIDS; HUMANS; LEGIONELLA PNEUMOPHILA; LEGIONNAIRES' DISEASE; MALE; PLASMA EXCHANGE; PNEUMONIA, BACTERIAL; PURPURA, THROMBOTIC THROMBOCYTOPENIC; SEVERITY OF ILLNESS INDEX;

EID: 80052764359     PISSN: 10752765     EISSN: 15363686     Source Type: Journal    
DOI: 10.1097/MJT.0b013e3181d1b4a1     Document Type: Review

References (37)

1. Takahashi H, TatewakiW, Nakamura T, et al. Coagulation studies in thrombotic thrombocytopenic purpura, with special reference to von Willebrand factor and protein S. Am J Hematol. 1989;30:14-21. (Pubitemid 19022732)
2. Furlan M, Robles R, Galbusera M, et al. von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N Engl J Med. 1998;339:1578-1584. (Pubitemid 28536132)
3. Kokame K, Matsumoto M, Soejima K, et al. Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity. Proc Natl Acad Sci USA. 2002;99:11902-11907. (Pubitemid 34994496)
4. Mitra D, Jaffe EA, Weksler B, et al. Thrombotic thrombocytopenic purpura and sporadic hemolytic-uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells. Blood. 1997;89:1224-1234. (Pubitemid 27079986)
5. Asada Y, Sumiyoshi A, Hayashi T, et al. Immunohistochemistry of vascular lesion in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen. Thromb Res. 1985;38:469-479. (Pubitemid 15041946)
6. Koenig DW, Barley-Maloney L, Daniel TO. A western blot assay detects autoantibodies to cryptic endothelial antigens in thrombotic microangiopathies. J Clin Immunol. 1993;13:204-211. (Pubitemid 23151225)
7. Jimenez JJ, Jy W, Mauro LM, et al. Endothelial microparticles released in thrombotic thrombocytopenic purpura express von Willebrand factor and markers of endothelial activation. Br J Haematol. 2003;123: 896-902. (Pubitemid 37533302)
8. Jimenez JJ, Jy W, Mauro LM, et al. Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease. Br J Haematol. 2001;112: 81-90. (Pubitemid 32151154)
9. Jy W, Jimenez JJ, Mauro LM, et al. Endothelial microparticles induce formation of platelet aggregates via a von Willebrand factor/ristocetin dependent pathway, rendering them resistant to dissociation. J Thromb Haemost. 2005; 3:1301-1308. (Pubitemid 41725256)
10. Tsai HM, Lian EC. Antibodies to von Willebrand factorcleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 1998;339:1585-1594. (Pubitemid 28536133)
11. Tsai HM, Rice L, Sarode R, et al. Antibody inhibitors to von Willebrand factor metalloproteinase and increased binding of von Willebrand factor to platelets in ticlopidine-associated thrombotic thrombocytopenic purpura. Ann Intern Med. 2000;132:794-799. (Pubitemid 30317794)
12. Ferrari S, Scheiflinger F, Rieger M, et al. Prognostic value of anti-ADAMTS 13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS 13 activity. Blood. 2007;109:2815-2822. (Pubitemid 46482076)
13. Soejima K, Matsumoto M, Kokame K, et al. ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage. Blood. 2003;102:3232-3237. (Pubitemid 37314760)
14. Klaus C, Plaimauer B, Studt JD, et al. Epitope mapping of ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura. Blood. 2004;103:4514-4519. (Pubitemid 38745978)
15. Lian EC. Pathogenesis of thrombotic thrombocytopenic purpura: ADAMTS13 deficiency and beyond. Semin Thromb Hemost. 2005;31:625-632. (Pubitemid 43063080)
16. Frangie C, Lefaucheur C, Medioni J, et al. Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma. Lancet Oncol. 2007;8:177-178. (Pubitemid 46158384)
17. Eremina V, Jefferson JA, Kowalewska J, et al. VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med. 2008;358:1129-1136. (Pubitemid 351398487)
18. Hohenstein B, Braun A, Amann KU, et al. A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy. Nephrol Dial Transplant. 2008;23:1144-1156. (Pubitemid 351767496)
19. Kwaan HC, Soff GA. Management of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Semin Hematol. 1997;34:159-166. (Pubitemid 27175074)
20. Sarode R, Gottschall JL, Aster RH, et al. Thrombotic thrombocytopenic purpura: early and late responders. Am J Hematol. 1997;54:102-107. (Pubitemid 27079415)
21. Byrnes JJ, Moake JL, Klug P, et al. Effectiveness of the cryosupernatant fraction of plasma in the treatment of refractory thrombotic thrombocytopenic purpura. Am J Hematol. 1990;34:169-174. (Pubitemid 20196686)
22. Bell WR, Braine HG, Ness PM, et al. Improved survival in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Clinical experience in 108 patients. N Engl J Med. 1991;325:398-403.
23. Petitt RM. Thrombotic thrombocytopenic purpura: a thirty year review. Semin Thromb Hemost. 1980;6:350-355. (Pubitemid 11151263)
24. Rosove MH, Ho WG, Goldfinger D. Ineffectiveness of aspirin and dipyridamole in the treatment of thrombotic thrombocytopenic purpura. Ann Intern Med. 1982;96:27-33. (Pubitemid 12205511)
25. Eldor A. Thrombotic thrombocytopenic purpura: diagnosis, pathogenesis and modern therapy. Baillieres Clin Haematol. 1998;11:475-495. (Pubitemid 29103558)
26. Lian EC, Mui PT, Siddiqui FA, et al. Inhibition of plateletaggregating activity in thrombotic thrombocytopenic purpura plasma by normal adult immunoglobulin G. J Clin Invest. 1984;73:548-555. (Pubitemid 14194636)
27. Scully M, Cohen H, Cavenagh J, et al. Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13. Br J Haematol. 2007;136:451-461. (Pubitemid 46046304)
28. Ezra Y, Mordel N, Sadovsky E, et al. Successful pregnancies of two patients with relapsing thrombotic thrombocytopenic purpura. Int J Gynaecol Obstet. 1989;29: 359-363. (Pubitemid 19223111)
29. Lenz HJ, Jaschonek K, Schuler U, et al. Splenectomy for chronic thrombotic thrombocytopenic purpura. Lancet. 1990;335:1593. (Pubitemid 20189669)
30. Bird JM, Cummins D, Machin SJ. Cyclophosphamide for chronic relapsing thrombotic thrombocytopenic purpura. Lancet. 1990;336:565-566. (Pubitemid 20278126)
31. Moake JL, Rudy CK, Troll JH, et al. Therapy of chronic relapsing thrombotic thrombocytopenicpurpura with prednisone and azathioprine. Am J Hematol. 1985;20:73-79. (Pubitemid 15229474)
32. Riggs SA, Wray NP, Waddell CC, et al. Thrombotic thrombocytopenic purpura complicating Legionnaires' disease. Arch Intern Med. 1982;142:2275-2280. (Pubitemid 13210250)
33. Chiaraviglio L, Brown DA, Kirby JE. Infection of cultured human endothelial cells by Legionella pneumophila. PLoS One. 2008;3:E2012.
34. von Baum H, Ewig S, Marre R, et al. Communityacquired Legionella pneumonia: new insights from the German competence network for community acquired pneumonia. Clin Infect Dis. 2008;46:1356-1364. (Pubitemid 351589933)
35. Bar Meir E, Amital H, Levy Y, et al. Mycoplasma pneumoniae-induced thrombotic thrombocytopenic purpura. Acta Haematol. 2000;103:112-115.
36. de Man AM, Smulders YM, Roozendaal KJ, et al. HIVrelated thrombotic thrombocytopenic purpura: report of 2 cases and a review of the literature. Neth J Med. 1997; 51:103-109. (Pubitemid 27450526)
37. Kiki I, Gundogdu M, Albayrak B, et al. Thrombotic thrombocytopenic purpura associated with Brucella infection. Am J Med Sci. 2008;335:230-232. (Pubitemid 351417095)