Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: Findings from brain and renal microvascular cell culture and patients with active disease

British Journal of Haematology

Volumn 112, Issue 1, 2001, Pages 81-90

  Jimenez, Joaquin J ^a   Jy, Wenche ^a   Mauro, Lucia M ^a   Horstman, Lawrence L ^a   Ahn, Yeon S ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Endothelial activation; Endothelial microparticles; Thrombosis; Thrombotic thrombocytopenic purpura

Indexed keywords

CD31 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MITOMYCIN C; PROCOAGULANT; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; APOPTOSIS; ARTICLE; BRAIN CELL; CASE REPORT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KIDNEY CELL; PRIORITY JOURNAL; THROMBOTIC THROMBOCYTOPENIC PURPURA; VASCULAR ENDOTHELIUM;

ADULT; AGED; APOPTOSIS; BLOOD COAGULATION TESTS; BRAIN; CASE-CONTROL STUDIES; CELL DEATH; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; FEMALE; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; INTERCELLULAR ADHESION MOLECULE-1; KIDNEY; MICROCIRCULATION; PLATELET ACTIVATION; PURPURA, THROMBOTIC THROMBOCYTOPENIC; STATISTICS, NONPARAMETRIC; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0035138106     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02516.x     Document Type: Article

References (46)

1. Vincristine therapy of idiopathic and secondary thrombocytopenias
2. Activated platelet aggregates in thrombotic thrombocytopenic purpura: Decrease with plasma infusions and normalization in remission
3. Immunohistochemistry of vascular lesions in thrombotic thrombocytopenic purpura, with special reference to factor VIII related antigen
4. Differentiation of endothelial cells: Analysis of the constitutive and activated endothelial cell phenotypes
5. Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome relapse: Frequency, pathogenesis, and meaning
6. Apoptotic vascular endothelial cells become procoagulant
7. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: Implications for coagulation events and antigenic spread in systemic lupus erythematosus
8. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant
9. Enhanced endothelial cell apoptosis in splenic tissues of patients with thrombotic thromobytopenic purpura
10. Von Willebrand factor cleaving protease in acute thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
11. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
12. Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex
13. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells
14. Apoptosis of endothelial cells is associated with paracrine induction of adhesion molecules - Evidence for an interleukin-1ß dependent paracrine loop
15. Platelet microparticles: A wideangle perspective
16. Clinical significance of platelet microparticles in autoimmune thrombocytopenias
17. Platelet factor 3 in plasma fractions: Its relation to microparticle size and thromboses
18. Optimized medium for clonal growth of human microvascular endothelial cells with minimal serum
19. The influence exerted by a restricted phospholipid microenvironment on the expression of tissue factor activity at the cell plasma membrane surface
20. Apoptosis of microvascular endothelial cells in the pathophysiology of thrombotic thrombocytopenic purpura/sporadic hemolytic uremic syndrome
21. Plasma from patients with idiopathic and human immunodeficiency virus-associated thrombotic thrombocyopenic purpura induces apoptosis in microvascular endothelial cells
22. Presence of a platelet aggregating factor in the plasma of patients with TTP and its inhibition by normal plasma
23. Inhibition of platelet aggregating activity in TTP plasma by normal adult immunoglobulin G
24. Multiple forms of angiostatin induce apoptosis in endothelial cells
25. Thrombotic thrombocytopenic purpura and sporadic hemolytic uremic syndrome plasmas induce apoptosis in restricted lineages of human microvascular endothelial cells
26. Role of caspases 1 and 3 and Bcl-2-related molecules in endothelial cell apoptosis associated with thrombotic microangiopathies
27. Thrombotic thrombocytopenic purpura
28. Thrombotic thrombocypenic purpura: Understanding a disease no longer rare
29. Abnormalities of von Willebrand factor multimers in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
30. Unusually large plasma factor VIII: Von Willebrand factor multimers in chronic relapsing TTP
31. Modulation of endothelial cell hemostatic properties by tumor necrosis factor
32. Antiphospholipid antibody positive sera enhance endothelial cell procoagulant activity - Studies in a thrombosis model
33. Thrombotic thrombocytopenic purpura: Report of 25 cases and review of the literature
34. Hemostatic properties of normal and perturbed vascular cells
35. The pathophysiology and management of thrombotic thrombocytopenic purpura
36. Anti-CD36 autoantibodies in thrombotic thrombocytopenic purpura and other thrombotic disorders: Identification of an 85kd form of CD36 as a target antigen
37. Activation of cultured vascular endothelial cells by antiphospholipid andtibodies
38. Sickle cell anemia as a possible state of enhanced anti-apoptotic tone: Survival effect of vascular endothelial growth factor on circulating and unanchored endothelial cells
39. Circulating thrombomodulin in thrombotic thrombocytopenic purpura
40. Anti-CD36 antibodies in thrombotic thrombocytopenic pupura
41. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura
42. Thrombotic thrombocytopenic purpura (TTP) plasma enhances platelet-leukocyte interaction in vitro
43. Increased levels of vascular endothelial cell markers in thrombotic thrombocytopenic purpura
44. Effect of complement proteins C5b-9 on blood platelets
45. Characterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpura
46. Plasma from a patient with thrombotic thrombocytopenic purpura induces endothelial cell apoptosis and platelet aggregation