No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Annals of Hepatology

Volumn 10, Issue 4, 2011, Pages 445-451

  Urbánek, Petr ^a   Leníček, Martin ^a   Muchová, Lucie ^a   Subhanová, Iva ^a   Dušek, Ladislav ^b   Kaspříková, Nikola ^a   Hrabal, Petr ^c   Brůha, Radan ^a   Vítek, Libor ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c CENTRAL MILITARY HOSPITAL   (Czech Republic)

Author keywords

Bilirubin; Bilirubin UDP glucuronosyltransferase; Genetic predisposition; Heme oxygenase; Oxidative stress

Indexed keywords

DINUCLEOTIDE; DNA; GLUCURONOSYLTRANSFERASE 1A1; HEME OXYGENASE 1; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS C; HISTOPATHOLOGY; HMOX1 GENE; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER PROTECTION; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; OXIDATIVE STRESS; PREVALENCE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; UGT1A1 GENE; VIRUS LOAD;

EID: 80052719924     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31511-x     Document Type: Article

References (26)

1. Farombi EO, Surh YJ. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J Biochem Mol Biol 2006; 39: 479-91.
2. Vitek L, Ostrow JD. Bilirubin chemistry and metabolism; harmful and protective aspects. Curr Pharm Des 2009; 15: 2869-83.
3. Lin JP, Vitek L, Schwertner HA. Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. Clin Chem 2010; 56: 1535-43.
4. Exner M, Minar E, Wagner O, Schillinger M. The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004; 37: 1097-104.
5. Muriel P. Role of free radicals in liver diseases. Hepatol Int 2009; 3: 526-36.
6. Moriya K, Nakagawa K, Santa T, Shintani Y, Fujie H, Miyoshi H, Tsutsumi T, et al. Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res 2001; 61: 4365-70.
7. Abdalla MY, Britigan BE, Wen F, Icardi M, McCormick ML, LaBrecque DR, Voigt M, et al. Down-regulation of heme oxynase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. J Infect Dis 2004; 190: 1109-18.
8. Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defences. J Med Virol 2005; 76: 489-97.
9. Ghaziani T, Shan Y, Lambrecht WR, Donohue SE, Pietschmann T, Bartenschlager R, Bonkovsky HL. HCV proteins increase expression of heme oxygenase-1 (HO-1) and decrease expression of Bach1 in human hepatoma cells. J Hepatol 2006; 45: 5-12.
10. Zhu Z, Wilson TA, Mathis MM, Wen F, Bown KE, Luxon BA, Schmidt WN. Heme oxygenase-1 suppresses Hepatitis C virus replication and increases resistance of hepatocytes to oxidant injury. Hepatology 2008; 28: 1430-9.
11. Lehman E, El-Tantawy WH, Ocker M, Bartenschlager R, Lohmann V, Hashemolhosseini S, Tiegs G, et al. The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response. Hepatology 2010; 51: 398-404.
12. Bonkovsky HL, Lambrecht RW, Naishadham D. Genetic variations in heme oxygenase-1 and chronic hepatitis. Hepatology 2010; 52: 400 [Letter].
13. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22: 696-9.
14. Jiraskova A, Lenicek M, Vitek L. Simultaneous genotyping of microsatellite variations in HMOX1 and UGT1A1 genes using multicolored capillary electrophoresis. Clin Biochem 2010; 43: 697-9.
15. Fu WP, Zhoa Z, Fang L, Sun Ch, Zhang J, Zhang Y, Dai L. Heme oxygenase-1 polymorphism associated with severity of chronic obstructive pulmonary disease. Chin Med J 2007; 120: 12-6.
16. Fredenburgh LE, Perrella MA, Mitsialis A. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol 2007; 36: 158-65.
17. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci USA 1968; 61: 748-55.
18. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-6.
19. Chiu H, Brittingham JA, Laskin DL. Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: effects of hemin and biliverdin. Toxicol Appl Pharmacol 2002; 181: 106-15.
20. Pianko S, Patella S, Ostapowicz G, Desmond P, Sievert W. Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection. J Viral Hepat 2001; 8: 406-13.
21. Ming-Ju H, Yih-Shou H, Tzy-Yen C, Hui-Ling C. Hepatitis C virus E2 protein induce reactive oxygen species (ROS)-related fibrogenesis in the HSC-T6 hepatic stellate cell line. J Cell Biochem 2011; 112: 233-43.
22. Lin W, Tsai WL, Shao RX, Wu G, Peng LF, Barlow LL, Chung WJ, et al. Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. Gastroenterology 2010; 138: 2509-18.
23. Choi J, Ou JH. Mechanisms of liver injury III. Oxidative stress in the pathogenesis of hepatitis C virus. Am J Physiol Gastrointest Liver Physiol 2006; 290: G847-51.
24. Hou WH, Ross L, Shan Y, Zheng JY, Lambrecht RW, Bonkovsky HL. Iron increases HMOX1 and decreases hepatitis C viral expression in HCV-expressing cells. World J Gastroenterol 2009; 15: 4499-510.
25. Ghany MG, Strader DB, Thomas DL, Seeff LB; American Association for the Study of Liver Diseases. Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009; 49: 1335-74.
26. Taha H, Skrzypek K, Guevara I, Nigish A, Mustafa S, Grochot-Przeczek A, Ferdek P, et al. Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants. Arterioscler Thromb Vasc Biol 2010; 30: 1634-41.