Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages

Glycobiology

Volumn 20, Issue 1, 2010, Pages 24-32

  Brumshtein, Boris ^a   Salinas, Paul ^b   Peterson, Brian ^b   Chan, Victor ^b   Silman, Israel ^a   Sussman, Joel L ^a   Savickas, Philip J ^b   Robinson, Gregory S ^b   Futerman, Anthony H ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b SHIRE   (United States)

Author keywords

Gaucher disease; Gene activation; Glucocerebrosidase; Glycans; Mannose 6 phosphate receptor; Site specific glycosylation; X ray structure

Indexed keywords

GALACTOSYLCERAMIDASE; GLUCOSYLCERAMIDASE; IMIGLUCERASE; UNCLASSIFIED DRUG; VELAGLUCERASE ALFA;

ARTICLE; CATALYSIS; CHEMICAL COMPOSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME KINETICS; GAUCHER DISEASE; GLYCOSYLATION; HUMAN; HUMAN CELL; INTERNALIZATION; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN HYDROLYSIS;

ANIMALS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; DAUCUS CAROTA; GLUCOSYLCERAMIDASE; GLYCOSYLATION; HUMANS; KINETICS; MACROPHAGES; MOLECULAR CONFORMATION; PLANTS, GENETICALLY MODIFIED;

CRICETULUS GRISEUS; DAUCUS CAROTA;

EID: 70849126444     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwp138     Document Type: Article

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