Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci

Protein Engineering, Design and Selection

Volumn 24, Issue 10, 2011, Pages 791-799

  Pruzina, Sara ^a   Williams, Gareth T ^a   Kaneva, Galina ^a   Davies, Sarah L ^a,f   Martín López, Alicia ^a,b   Brüggemann, Marianne ^c   Vieira, Sueli M ^d   Jeffs, Simon A ^d   Sattentau, Quentin J ^e   Neuberger, Michael S ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b UNIVERSITY OF ALMERÍA   (Spain)

^c Recombinant Antibody Technology Ltd   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

affinity maturation; antibody engineering; humanised mice; somatic mutation; transgenic mice

Indexed keywords

AFFINITY MATURATION; ANTIBODY ENGINEERING; HUMANISED MICE; SOMATIC MUTATION; TRANSGENIC MICE;

ANTIGENS; CLONE CELLS; DISEASES; MONOCLONAL ANTIBODIES; PLANTS (BOTANY); SURFACE PLASMON RESONANCE;

MAMMALS;

EPITOPE; GLYCOPROTEIN GP 140; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNOGLOBULIN; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN KAPPA CHAIN;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL CLONING; CHEMICAL STRUCTURE; GENE LOCUS; GERM LINE; HYBRIDOMA; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC HYPERMUTATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTIBODIES, MONOCLONAL; B-LYMPHOCYTE SUBSETS; CHROMOSOMES, ARTIFICIAL, YEAST; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENES, IMMUNOGLOBULIN; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; MICE; MICE, TRANSGENIC; TRANSLOCATION, GENETIC;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS; MUS MUSCULUS;

EID: 80052688852     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzr038     Document Type: Article

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