Connexin43 expression increases in the epithelium and stroma along the colonic neoplastic progression pathway: Implications for its oncogenic role

Gastroenterology Research and Practice

Volumn , Issue , 2011, Pages

  Furth, Emma E ^b   Han, Yusheng ^a   Zhang, Paul J ^b   Chen, Terina ^b   Yum, Sabrina W ^c   Pasha, Teresa ^b  

^a PENNSYLVANIA HOSPITAL   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CONNEXIN 43; WNT PROTEIN;

ADULT; ARTICLE; CANCER STAGING; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON MUCOSA; DISEASE COURSE; FEMALE; GAP JUNCTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR MECHANICS; PATHOGENESIS;

EID: 80052675348     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2011/561719     Document Type: Article

References (43)

1. Kanczuga-Koda L., Sulkowski S., Lenczewski A., Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer Journal of Clinical Pathology 2006 59 4 429 433
2. Krutovskikh V. A., Piccoli C., Yamasaki H., Gap junction intercellular communication propagates cell death in cancerous cells Oncogene 2002 21 13 1989 1999 (Pubitemid 34270887)
3. Trosko J. E., Ruch R. J., Cell-cell communication in carcinogenesis Frontiers in Bioscience 1998 3 208 236
4. Umhauer S., Ruch R. J., Fanning J., Gap junctional intercellular communication and connexin 43 expression in ovarian carcinoma American Journal of Obstetrics and Gynecology 2000 182 5 999 1000 (Pubitemid 30353260)
5. Ruch R. J., Porter S., Koffler L. D., Dwyer-Nield L. D., Malkinson A. M., Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation Experimental Lung Research 2001 27 3 231 243 (Pubitemid 32239295)
6. Gee J., Tanaka M., Grossman H. B., Connexin 26 is abnormally expressed in bladder cancer Journal of Urology 2003 169 3 1135 1137 (Pubitemid 36188188)
7. Bates D. C., Sin W. C., Aftab Q., Naus C. C., Connexin43 enhances glioma invasion by a mechanism involving the carboxy terminus GLIA 2007 55 15 1554 1564 (Pubitemid 47556259)
8. Graeber S. H. M., Hlser D. F., Connexin transfection induces invasive properties in HeLa cells Experimental Cell Research 1998 243 1 142 149 (Pubitemid 28397643)
9. Cronier L., Crespin S., Strale P. O., Defamie N., Mesnil M., Gap junctions and cancer: new functions for an old story Antioxidants Redox Signaling 2009 11 2 323 338
10. Aasen T., Hodgins M. B., Edward M., Graham S. V., The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression Oncogene 2003 22 39 7969 7980 (Pubitemid 37175862)
11. Lin J. H. C., Takano T., Cotrina M. L., Connexin 43 Enhances the adhesivity and mediates the invasion of malignant glioma cells Journal of Neuroscience 2002 22 11 4302 4311 (Pubitemid 37465645)
12. El-Sabban M. E., Pauli B. U., Adhesion-mediated gap junctional communication between lung-metastatatic cancer cells and endothelium Invasion and Metastasis 1994 14 16 164 176
13. Nemeth L., Maddur S., Puri P., Immunolocalization of the gap junction protein connexin43 in the interstitial cells of cajal in the normal and hirschsprung's disease bowel Journal of Pediatric Surgery 2000 35 6 823 828 (Pubitemid 30346171)
14. Dubina M. V., Iatckii N. A., Popov D. E., Vasil'ev S. V., Krutovskikh V. A., Connexin 43, but not connexin 32, is mutated at advanced stages of human sporadic colon cancer Oncogene 2002 21 32 4992 4996
15. Sheen I. S., Jeng K. S., Wang P. C., Are gap junction gene connexins 26, 32 and 43 of prognostic values in hepatocellular carcinoma? A prospective study World Journal of Gastroenterology 2004 10 19 2785 2790
16. Zhang D., Kaneda M., Nakahama K. I., Arii S., Morita I., Connexin 43 expression promotes malignancy of HuH7 hepatocellular carcinoma cells via the inhibition of cell-cell communication Cancer Letters 2007 252 2 208 215 (Pubitemid 46809791)
17. Daniel-Wjcik A., Misztal K., Bechyne I., Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations International Journal of Oncology 2008 33 2 309 315
18. Kanczuga-Koda L., Sulkowski S., Lenczewski A., Increased expression of connexins 26 and 43 in lymph node metastases of breast cancer Journal of Clinical Pathology 2006 59 4 429 433
19. Pollmann M. A., Shao Q., Laird D. W., Sandig M., Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture Breast Cancer Research 2005 7 4 R522 R534
20. Elzarrad M. K., Haroon A., Willecke K., Dobrowolski R., Gillespie M. N., Al-Mehdi A. B., Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium BMC Medicine 2008 6, article 20
21. Chen J. T., Cheng Y. W., Chou M. C., The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer Clinical Cancer Research 2003 9 11 4200 4204
22. Mahmoud N. N., Bilinski R. T., Churchill M. R., Edelmann W., Kucherlapati R., Bertagnolli M. M., Genotype-phenotype correlation in murine Apc mutation: differences in enterocyte migration and response to sulindac Cancer Research 1999 59 2 353 359 (Pubitemid 29048867)
23. Baeg G. H., Matsumine A., Kuroda T., The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase The EMBO Journal 1995 14 22 5618 5625
24. Morin P. J., Vogelstein B., Kinzler K. W., Apoptosis and APC in colorectal tumorigenesis Proceedings of the National Academy of Sciences of the United States of America 1996 93 15 7950 7954 (Pubitemid 26277145)
25. Wong M. H., Hermiston M. L., Syder A. J., Gordon J. I., Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium Proceedings of the National Academy of Sciences of the United States of America 1996 93 18 9588 9593 (Pubitemid 26296652)
26. Cottrell S., Bicknell D., Kaklamanis L., Bodmer W. F., Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas The Lancet 1992 340 8820 626 630
27. Sparks A. B., Morin P. J., Vogelstein B., Kinzler K. W., Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer Cancer Research 1998 58 6 1130 1134 (Pubitemid 28183198)
28. Otori K., Konishi M., Sugiyama K., Infrequent somatic mutation of the adenomatous polyposis coli gene in aberrant crypt foci of human colon tissue Cancer 1998 83 5 896 900 (Pubitemid 28401922)
29. van der Heyden M. A. G., Rook M. B., Hermans M. M. P., Identification of connexin43 as a functional target for Wnt signalling Journal of Cell Science 1998 111, part 12 1741 1749 (Pubitemid 28330560)
30. Husy T., Knutsen H. K., Cruciani V., Connexin43 is overexpressed in Apc Min/+ -mice adenomas and colocalises with COX-2 in myofibroblasts International Journal of Cancer 2005 116 3 351 358 (Pubitemid 40993330)
31. Araki Y., Okamura S., Hussain S. P., Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways Cancer Research 2003 63 3 728 734 (Pubitemid 36158154)
32. Shtutman M., Zhurinsky J., Simcha I., The cyclin D1 gene is a target of the b-catenin/LEF-1 pathway Proceedings of the National Academy of Sciences of the United States of America 1999 96 10 5522 5527 (Pubitemid 29234650)
33. He T. C., Chan T. A., Vogelstein B., Kinzler K. W., PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs Cell 1999 99 3 335 345 (Pubitemid 29519912)
34. Nicolson G. L., Dulski K. M., Trosko J. E., Loss of intercellular junctional communication correlates with metastatic potential in mammary adenocarcinoma cells Proceedings of the National Academy of Sciences of the United States of America 1988 85 2 473 476
35. Carystinos G. D., Bier A., Batist G., The role of connexin-mediated cell-cell communication in breast cancer metastasis Journal of Mammary Gland Biology and Neoplasia 2001 6 4 431 440
36. Chen S. C., Pelletier D. B., Ao P., Boynton A. L., Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases Cell Growth and Differentiation 1995 6 6 681 690
37. Lecanda F., Towler D. A., Ziambaras K., Gap junctional communication modulates gene expression in osteoblastic cells Molecular Biology of the Cell 1998 9 8 2249 2258 (Pubitemid 28373637)
38. Lin J. H. C., Takano T., Cotrina M. L., Connexin43 enhances the adhesivity and mediates the invasion of malignant glioma cells Journal of Neuroscience 2002 22 11 4302 4311 (Pubitemid 37465645)
39. Mareel M., Leroy A., Clinical, cellular, and molecular aspects of cancer invasion Physiological Reviews 2003 83 2 337 376 (Pubitemid 36382891)
40. Ai Z., Fischer A., Spray D. C., Brown A. M. C., Fishman G. I., Wnt-1 regulation of connexin43 in cardiac myocytes Journal of Clinical Investigation 2000 105 2 161 171 (Pubitemid 30054355)
41. Chung G. G., Provost E., Kielhorn E. P., Charette L. A., Smith B. L., Rimm D. L., Tissue microarray analysis of beta-catenin in colorectal cancer shows nuclear phospho-beta-catenin is associated with a better prognosis Clinical Cancer Research 2001 7 12 4013 4020 (Pubitemid 34044621)
42. Lugli A., Zlobec I., Minoo P., Prognostic significance of the wnt signalling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis Histopathology 2007 50 4 453 464 (Pubitemid 46328181)
43. McKaig B. C., Makh S. S., Hawkey C. J., Podolsky D. K., Mahida Y. R., Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3 American Journal of Physiology 1999 276 5 G1087 G1093 (Pubitemid 29251906)