KIOM-79, an inhibitor of AGEs-protein cross-linking, prevents progression of nephropathy in Zucker diabetic fatty rats

Evidence-based Complementary and Alternative Medicine

Volumn 2011, Issue , 2011, Pages

  Kim, Jin Sook ^a   Kim, Young Sook ^a   Kim, Junghyun ^a   Kim, Chan Sik ^a   Sohn, Eun Jin ^a   Lee, Yun Mi ^a   Jeong, Il Ha ^a   Kim, Hyojun ^a   Jang, Dae Sik ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALBUMIN; CHOLESTEROL; COLLAGEN; CREATININE; EUPHORBIA EXTRACT; FATTY ACID; FIBRINOGEN; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; GLYCYRRHIZA EXTRACT; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KIOM 79; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNOLIA EXTRACT; MESSENGER RNA; PROTEIN; PUERARIA EXTRACT; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE URINE LEVEL; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULOSCLEROSIS; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CORTEX; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY MASS; KIDNEY TUBULE DISORDER; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION; PODOCYTE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RAT; TREATMENT DURATION; ZUCKER DIABETIC FATTY RAT;

EID: 80052672697     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1093/ecam/nep078     Document Type: Article

References (30)

1. Brownlee M., The pathobiology of diabetic complications: a unifying mechanism Diabetes 2005 54 6 1615 1625 (Pubitemid 40770750)
2. Huebschmann A. G., Vlassara H., Regensteiner J. G., Reusch J., Diabetes and advanced glycoxidation end products Annual Review of Diabetes 2007 51 63
3. Alderson N. L., Chachich M. E., Youssef N. N., Beattie R. J., Nachtigal M., Thorpe S. R., Baynes J. W., The AGE inhibitor pyridoxamine inhibits lipemia and development of renal and vascular disease in Zucker obese rats Kidney International 2003 63 6 2123 2133 (Pubitemid 36605823)
4. Figarola J. L., Scott S., Loera S., Tessler C., Chu P., Weiss L., Hardy J., Rahbar S., Lr-90 a new advanced glycation endproduct inhibitor prevents progression of diabetic nephropathy in streptozotocin-diabetic rats Diabetologia 2003 46 8 1140 1152 (Pubitemid 37041245)
5. Peppa M., Brem H., Cai W., Zhang J.-G., Basgen J., Li Z., Vlassara H., Uribarri J., Prevention and reversal of diabetic nephropathy in db/db mice treated with alagebrium (ALT-711) American Journal of Nephrology 2006 26 5 430 436 (Pubitemid 44971733)
6. Chander P. N., Gealekman O., Brodsky S. V., Elitok S., Tojo A., Crabtree M., Gross S. S., Goligorsky M. S., Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen Journal of the American Society of Nephrology 2004 15 9 2391 2403 (Pubitemid 39159339)
7. Coimbra T. M., Janssen U., Grne H. J., Ostendorf T., Kunter U., Schmidt H., Brabant G., Floege J., Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes Kidney International 2000 57 1 167 182 (Pubitemid 30227764)
8. Li W. L., Zheng H. C., Bukuru J., De Kimpe N., Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus Journal of Ethnopharmacology 2004 92 1 1 21 (Pubitemid 38510258)
9. Hur J., Donguibogam Parallel Version 1999 Seoul, Korea Bupin 1979
10. Jeon Y. J., Li M. H., Lee K. Y., Kim J. S., You H. J., Lee S. K., Sohn H. M., Choi S. J., Koh J. W., Chang I. Y., KIOM-79 inhibits LPS-induced iNOS gene expression by blocking NF- B/Rel and p38 kinase activation in murine macrophages Journal of Ethnopharmacology 2006 108 1 38 45 (Pubitemid 44498987)
11. Kim Y. S., Lee Y. M., Kim C.-S., Sohn E. J., Jang D. S., Kim J. S., Inhibitory effect of KIOM-79, a new herbal prescription, on AGEs formation and expression of type IV collagen and TGF- 1 in STZ-induced diabetic rats Korean Journal of Pharmacogn 2006 37 103 109 (Pubitemid 44048802)
12. Kim C.-S., Sohn E. J., Kim Y. S., Jung D. H., Jang D. S., Lee Y. M., Kim D.-H., Kim J. S., Effects of KIOM-79 on hyperglycemia and diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats Journal of Ethnopharmacology 2007 111 2 240 247 (Pubitemid 46528078)
13. Vasan S., Netram K., Zhang X., Wagle D., Ramdass R., Shih D., Identification of new inhibitors of AGE-protein crosslinking using a novel ELISA (Abstract) Diabetes 1996 45 A258
14. Vasan S., Zhang X., Zhang X., Kapurniotu A., Bernhagen J., Teichberg S., Basgen J., Wagle D., Shih D., Terlecky I., Bucala R., Cerami A., Egan J., Ulrich P., An agent cleaving glucose-derived protein crosslinks in vitro and in vivo Nature 1996 382 6588 275 278 (Pubitemid 26251366)
15. Kim Y. S., Jung D. H., Kim N. H., Lee Y. M., Jang D. S., Song G.-Y., Kim J. S., KIOM-79 inhibits high glucose or AGEs-induced VEGF expression in human retinal pigment epithelial cells Journal of Ethnopharmacology 2007 112 1 166 172 (Pubitemid 46702431)
16. Kim Y.-S., Xu Z.-G., Reddy M. A., Li S.-L., Lanting L., Sharma K., Adler S. G., Natarajan R., Novel interactions between TGF- 1 actions and the 12/15-lipoxygenase pathway in mesangial cells Journal of the American Society of Nephrology 2005 16 2 352 362 (Pubitemid 41725130)
17. Mundel P., Heid H. W., Mundel T. M., Krger M., Reiser J., Kriz W., Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes Journal of Cell Biology 1997 139 1 193 204 (Pubitemid 27444091)
18. Schiffer M., Mundel P., Shaw A. S., Bttinger E. P., A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-beta-induced apoptosis The Journal of Biological Chemistry 2004 279 37004 37012 (Pubitemid 39129050)
19. Kang K. A., Lee K. H., Kim S. Y., Kim H. S., Kim J. S., Hyun J. W., Cytoprotective effects of KIOM-79 on streptozotocin induced cell damage by inhibiting ERK and AP-1 Biological and Pharmaceutical Bulletin 2007 30 5 852 858 (Pubitemid 46708625)
20. Paul J. T., Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation end products Archives of Biochemistry and Biophysics 2003 419 31 40
21. Padival S., Nagaraj R. H., Pyridoxamine inhibits maillard reactions in diabetic rat lenses Ophthalmic Research 2006 38 5 294 302 (Pubitemid 44492180)
22. Tanimoto M., Gohda T., Kaneko S., Hagiwara S., Murakoshi M., Aoki T., Yamada K., Ito T., Matsumoto M., Horikoshi S., Tomino Y., Effect of pyridoxamine (K-163), an inhibitor of advanced glycation end products, on type 2 diabetic nephropathy in KK-Ay/Ta mice Metabolism 2007 56 2 160 167 (Pubitemid 46074060)
23. Odetti P., Pesce C., Traverso N., Menini S., Maineri E. P., Cosso L., Valentini S., Patriarca S., Cottalasso D., Marinari U. M., Pronzato M. A., Comparative trial of N-acetyl-cysteine, taurine, and oxerutin on skin and kidney damage in long-term experimental diabetes Diabetes 2003 52 2 499 505 (Pubitemid 36173209)
24. Manuely Keenoy B., Vertommen J., De Leeuw I., The effect of flavonoid treatment on the glycation and antioxidant status in type 1 diabetic patients Diabetes, Nutrition and Metabolism 1999 12 256 263
25. Price D. L., Rhett P. M., Thorpe S. R., Baynes J. W., Chelating activity of advanced glycation end-product inhibitors Journal of Biological Chemistry 2001 276 52 48967 48972
26. Wilkinson-Berka J. L., Kelly D. J., Koerner S. M., Jaworski K., Davis B., Thallas V., Cooper M. E., ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat Diabetes 2002 51 11 3283 3289 (Pubitemid 35246975)
27. Hoshi S., Shu Y., Yoshida F., Inagaki T., Sonoda J., Watanabe T., Nomoto K.-I., Nagata M., Podocyte injury promotes progressive nephropathy in zucker diabetic fatty rats Laboratory Investigation 2002 82 1 25 35 (Pubitemid 34072643)
28. Susztak K., Raff A. C., Schiffer M., Bttinger E. P., Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy Diabetes 2006 55 225 233 (Pubitemid 43343319)
29. Kim Y. S., Kim N. H., Jung D. H., Sohn E. J., Lee Y. M., Jang D. S., Effect of KIOM-79 on expression of TGF-beta2 in human lens epithelial cells under hyperglycemic conditions and in an in vitro rat model of cataract (Abstract) Diabetes 2008 57 A114
30. Kim J. H., Kim C.-S., Sohn E. J., Kim O. S., Lee Y. M., Jang D. S., Effects of KIOM-79 on diabetic retinopathy in Zucker diabetic fatty rat (Abstract) Diabetes 2008 57 A572