The clinicopathological significance of heat shock protein 70 and glutamine synthetase expression in hepatocellular carcinoma

Journal of Hepato-Biliary-Pancreatic Sciences

Volumn 18, Issue 4, 2011, Pages 544-550

  Shin, Eun ^a   Ryu, Han Suk ^a   Kim, Soo Hee ^a   Jung, Haeyoen ^a   Jang, Ja June ^a   Lee, Kyoungbun ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

GS; Hepatocellular carcinoma; HSP70; Prognosis

Indexed keywords

GLUTAMATE AMMONIA LIGASE; HEAT SHOCK PROTEIN 70;

ADULT; AGED; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER CELL CARCINOMA; LIVER PARENCHYMA; MALE; MOLECULAR PATHOLOGY; PROGNOSIS; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR VOLUME;

ADULT; AGED; CARCINOMA, HEPATOCELLULAR; FEMALE; GLUTAMATE-AMMONIA LIGASE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL;

EID: 80052666836     PISSN: 18686974     EISSN: 18686982     Source Type: Journal    
DOI: 10.1007/s00534-010-0367-0     Document Type: Article

References (24)

1. Qin LX, Tang ZY. The prognostic significance of clinical and pathological features in hepatocellular carcinoma. World J Gastroenterol. 2002;8:193-9.
2. Wittekind C. [Prognostic factors in liver tumors]. Verh Dtsch Ges Pathol. 1995;79:109-15.
3. Pang RW, Joh JW, Johnson PJ, Monden M, Pawlik TM, Poon RT. Biology of hepatocellular carcinoma. Ann Surg Oncol. 2008;15:962-71.
4. Di Tommaso L, Franchi G, Park YN, Fiamengo B, Destro A, Morenghi E, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology. 2007;45:725-34. (Pubitemid 46450624)
5. Romanucci M, Bastow T, Della Salda L. Heat shock proteins in animal neoplasms and human tumours-a comparison. Cell Stress Chaperones. 2008;13:253-62.
6. Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy. J Leukoc Biol. 2007;81:15-27. (Pubitemid 46021247)
7. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006;31:164-72. (Pubitemid 43361923)
8. Sherman M, Multhoff G. Heat shock proteins in cancer. Ann N Y Acad Sci. 2007;1113:192-201. (Pubitemid 350015025)
9. Marsh JW, Dvorchik I, Subotin M, Balan V, Rakela J, Popechitelev EP, et al. The prediction of risk of recurrence and time to recurrence of hepatocellular carcinoma after orthotopic liver transplantation: a pilot study. Hepatology. 1997;26:444-50. (Pubitemid 27328324)
10. Pawlik TM, Delman KA, Vauthey JN, Nagorney DM, Ng IO, Ikai I, et al. Tumor size predicts vascular invasion and histologic grade: implications for selection of surgical treatment for hepatocellular carcinoma. Liver Transpl. 2005;11:1086-92. (Pubitemid 41341758)
11. Joo M, Chi JG, Lee H. Expressions of HSP70 and HSP27 in hepatocellular carcinoma. J Korean Med Sci. 2005;20:829-34. (Pubitemid 41587241)
12. Lim SO, Park SG, Yoo JH, Park YM, Kim HJ, Jang KT, et al. Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules. World J Gastroenterol. 2005;11:2072-9. (Pubitemid 40542649)
13. Barnes JA, Dix DJ, Collins BW, Luft C, Allen JW. Expression of inducible Hsp70 enhances the proliferation of MCF-7 breast cancer cells and protects against the cytotoxic effects of hyperthermia. Cell Stress Chaperones. 2001;6:316-25. (Pubitemid 33123484)
14. Diehl JA, Yang W, Rimerman RA, Xiao H, Emili A. Hsc70 regulates accumulation of cyclin D1 and cyclin D1-dependent protein kinase. Mol Cell Biol. 2003;23:1764-74. (Pubitemid 36246056)
15. Garg M, Kanojia D, Seth A, Kumar R, Gupta A, Surolia A, et al. Heat-shock protein 70-2 (HSP70-2) expression in bladder urothelial carcinoma is associated with tumour progression and promotes migration and invasion. Eur J Cancer. 2010;46: 207-15.
16. Kaur J, Das SN, Srivastava A, Ralhan R. Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: correlation with clinicopathological features. Oral Oncol. 1998;34:93-8. (Pubitemid 28207007)
17. Ralhan R, Kaur J. Differential expression of Mr 70, 000 heat shock protein in normal, premalignant, and malignant human uterine cervix. Clin Cancer Res. 1995;1:1217-22.
18. Milicevic ZT, Petkovic MZ, Drndarevic NC, Pavlovic MD, Todorovic VN. Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma-immunohistochemistry and Western blot analysis. Neoplasma. 2007;54:37-45.
19. Sidera K, Gaitanou M, Stellas D, Matsas R, Patsavoudi E. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem. 2008;283:2031-41.
20. Yin Y, Qin Q, Zhang W, Zhao J, Zhang C, Yu J. Overexpression of heat shock protein 70 and spontaneous cancer cell apoptosis in hepatocellular carcinoma. Zhonghua Gan Zang Bing Za Zhi. 2001;9:84-5.
21. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones. 2005;10:86-103. (Pubitemid 40942470)
22. Li H, Sui C, Kong F, Zhang H, Liu J, Dong M. Expression of HSP70 and JNK-related proteins in human liver cancer: potential effects on clinical outcome. Dig Liver Dis. 2007;39:663-70. (Pubitemid 46888210)
23. Osada T, Sakamoto M, Nagawa H, Yamamoto J, Matsuno Y, Iwamatsu A, et al. Acquisition of glutamine synthetase expression in human hepatocarcinogenesis: relation to disease recurrence and possible regulation by ubiquitin-dependent proteolysis. Cancer. 1999;85:819-31. (Pubitemid 29077558)
24. Osada T, Nagashima I, Tsuno NH, Kitayama J, Nagawa H. Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma. J Hepatol. 2000;33:247-53. (Pubitemid 30485228)