Expression of HSP70 and JNK-related proteins in human liver cancer: Potential effects on clinical outcome

Digestive and Liver Disease

Volumn 39, Issue 7, 2007, Pages 663-670

  Li, H ^a   Sui, C ^a   Kong, F ^a   Zhang, H ^a   Liu, J ^a   Dong, M ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Heat shock protein70; Immunohistochemistry; JNK; Liver carcinoma

Indexed keywords

HEAT SHOCK PROTEIN 70; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CANCER; LIVER CARCINOMA; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TUMOR DIFFERENTIATION; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; FEMALE; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 34250018756     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2007.03.011     Document Type: Article

References (23)

1. Wynn R.M., Davie J.R., Cox R.P., and Chuang D.T. Molecular chaperones: heat-shock proteins, foldases, and matchmakers. J Lab Clin Med 124 (1994) 31-36
2. Cardoso F., Di Leo A., Larsimont D., Gancberg D., Rouas G., Dolci S., et al. Evaluation of HER2, p53, bcl-2, topoisomerase II-alpha, heat shock proteins 27 and 70 in primary breast cancer and metastatic ipsilateral axillary lymph nodes. Ann Oncol 12 (2001) 615-620
3. Nylandsted J., Brand K., and Jaattela M. Heat shock protein 70 is required for the survival of cancer cells. Ann N Y Acad Sci 926 (2000) 122-125
4. Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
5. Kyriakis J.M., Banerjee P., Nikolakaki E., Dai T., Rubie E.A., Ahmad M.F., et al. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 (1994) 156-160
6. Chen Y.R., Meyer C.F., and Tan T.H. Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 271 (1996) 631-634
7. Sobin L.H., and Wittekind C.H. TNM classification of malignant tumours. 5th ed. (1997), John Wiley and Sons Inc., New York pp. 74-77
8. Wang Y., Cui Z.H., and Li K.Z. Relationship and significance of the expression of p15 and hsp70 genes in hepatocellular carcinoma. Chin J Clin Oncol Rehabil 11 (2004) 494-497 (in Chinese)
9. Papachristou D.J., Batistatou A., Sykiotis G.P., Varakis I., and Papavassiliou A.G. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. Bone 32 (2003) 364-371
10. Zhao Z.C., Zheng S.S., Wan Y.L., Jia C.K., and Xie H.Y. The molecular mechanism underlying angiogenesis in hepatocellular carcinoma: the imbalance activation of signaling pathways. Hepatobiliary Pancreat Dis Int 2 (2003) 529-536
11. Hartl F.U., and Hayer-Hartl M. Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295 (2002) 1852-1858
12. Jaattela M. Heat shock proteins as cellular lifeguards. Ann Med 31 (1999) 261-271
13. Jaattela M. Escaping cell death: survival proteins in cancer. Exp Cell Res 248 (1999) 30-43
14. Hu W., Wu W., Yeung S.C., Freedman R.S., Kavanagh J.J., and Verschraegen C.F. Increased expression of heat shock protein 70 in adherent ovarian cancer and mesothelioma following treatment with manumycin, a farnesyl transferase inhibitor. Anticancer Res 22 (2002) 665-672
15. Ciocca D.R., Clark G.M., Tandon A.K., Fuqua S.A., Welch W.J., and McGuire W.L. Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Natl Cancer Inst 85 (1993) 570-574
16. Volloch V.Z., and Sherman M.Y. Oncogenic potential of Hsp72. Oncogene 18 (1999) 3648-3651
17. Mosser D.D., Caron A.W., Bourget L., Denis-Larose C., and Massie B. Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol 17 (1997) 5317-5327
18. Huang S., Jiang Y., Li Z., Nishida E., Mathias P., Lin S., et al. Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b. Immunity 6 (1997) 739-749
19. Whitmarsh A.J., and Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74 (1996) 589-607
20. Papavassiliou A.G., Treier M., and Bohmann D. Intramolecular signal transduction in c-Jun. EMBO J 14 (1995) 2014-2019
21. Chen Y.N., Cheng C.C., Chen J.C., Tsauer W., and Hsu S.L. Norcantharidin-induced apoptosis is via the extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase signaling pathways in human hepatoma HepG2 cells. Br J Pharmacol 140 (2003) 461-470
22. Kumar Y., and Tatu U. Stress protein flux during recovery from simulated ischemia: induced heat shock protein 70 confers cytoprotection by suppressing JNK activation and inhibiting apoptotic cell death. Proteomics 3 (2003) 513-526
23. Park H.S., Lee J.S., Huh S.H., Seo J.S., and Choi E.J. Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase. EMBO J 20 (2001) 446-456