In vivo analysis of uropod function during physiological T cell trafficking

Journal of Immunology

Volumn 187, Issue 5, 2011, Pages 2356-2364

  Soriano, Silvia F ^a   Hons, Miroslav ^a   Schumann, Kathrin ^b   Kumar, Varsha ^a   Dennier, Timo J ^a   Lyck, Ruth ^a   Sixt, Michael ^b,c   Stein, Jens V ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^c INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MYOSIN II; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; RHO P160 COILED COIL KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL MOTILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; FEMALE; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE MIGRATION; LYMPHOID TISSUE; MALE; MICROENVIRONMENT; MOUSE; MULTIPHOTON MICROSCOPY; MUSCLE CONTRACTILITY; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN INTERACTION; T LYMPHOCYTE; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; UROPOD CONTRACTILITY;

ANIMALS; CELL POLARITY; CHEMOTAXIS, LEUKOCYTE; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; IMAGING, THREE-DIMENSIONAL; MALE; MICE; MICE, INBRED C57BL; MYOSIN TYPE II; PSEUDOPODIA; RHO-ASSOCIATED KINASES; T-LYMPHOCYTES; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

EID: 80052649537     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1100935     Document Type: Article

References (40)

1. Von Andrian, U. H., and T. R. Mempel. 2003. Homing and cellular traffic in lymph nodes. Nat. Rev. Immunol. 3: 867-878. (Pubitemid 37411716)
2. Cyster, J. G. 2005. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23: 127-159. (Pubitemid 40563167)
3. Junt, T., E. Scandella, and B. Ludewig. 2008. Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence. Nat. Rev. Immunol. 8: 764-775.
4. Stein, J. V., A. Rot, Y. Luo, M. Narasimhaswamy, H. Nakano, M. D. Gunn, A. Matsuzawa, E. J. Quackenbush, M. E. Dorf, and U. H. Von Andrian. 2000. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 191: 61-76.
5. Sánchez-Madrid, F., and M. A. Del Pozo. 1999. Leukocyte polarization in cell migration and immune interactions. EMBO J. 18: 501-511. (Pubitemid 29057235)
6. Kinashi, T. 2005. Intracellular signalling controlling integrin activation in lymphocytes. Nat. Rev. Immunol. 5: 546-559. (Pubitemid 40961332)
7. Thelen, M., and J. V. Stein. 2008. How chemokines invite leukocytes to dance. Nat. Immunol. 9: 953-959.
8. Miyasaka, M., and T. Tanaka. 2004. Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat. Rev. Immunol. 4: 360-370. (Pubitemid 38649278)
9. Azzali, G., M. L. Arcari, and G. F. Caldara. 2008. The "mode" of lymphocyte extravasation through HEVof Peyer's patches and its role in normal homing and inflammation. Microvasc. Res. 75: 227-237. (Pubitemid 351249862)
10. Shulman, Z., V. Shinder, E. Klein, V. Grabovsky, O. Yeger, E. Geron, A. Montresor, M. Bolomini-Vittori, S. W. Feigelson, T. Kirchhausen, et al. 2009. Lymphocyte crawling and transendothelial migration require chemokine triggering of high-affinity LFA-1 integrin. Immunity 30: 384-396.
11. Park, E. J., A. Peixoto, Y. Imai, A. Goodarzi, G. Cheng, C. V. Carman, U. H. Von Andrian, and M. Shimaoka. 2010. Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood 115: 1572-1581.
12. Boscacci, R. T., F. Pfeiffer, K. Gollmer, A. I. Sevilla, A. M. Martin, S. F. Soriano, D. Natale, S. Henrickson, U. H. Von Andrian, Y. Fukui, et al. 2010. Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing. Blood 116: 915-925.
13. Bajénoff, M., J. G. Egen, L. Y. Koo, J. P. Laugier, F. Brau, N. Glaichenhaus, and R. N. Germain. 2006. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25: 989-1001. (Pubitemid 44914055)
14. Woolf, E., I. Grigorova, A. Sagiv, V. Grabovsky, S. W. Feigelson, Z. Shulman, T. Hartmann, M. Sixt, J. G. Cyster, and R. Alon. 2007. Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces. Nat. Immunol. 8: 1076-1085. (Pubitemid 47423755)
15. Okada, T., and J. G. Cyster. 2007. CC chemokine receptor 7 contributes to Gi-dependent T cell motility in the lymph node. J. Immunol. 178: 2973-2978. (Pubitemid 46333176)
16. Worbs, T., T. R. Mempel, J. Bölter, U. H. Von Andrian, and R. Förster. 2007. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J. Exp. Med. 204: 489-495. (Pubitemid 46457073)
17. Mazo, I. B., M. Honczarenko, H. Leung, L. L. Cavanagh, R. Bonasio, W. Weninger, K. Engelke, L. Xia, R. P. McEver, P. A. Koni, et al. 2005. Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells. Immunity 22: 259-270. (Pubitemid 40255716)
18. Tybulewicz, V. L., and R. B. Henderson. 2009. Rho family GTPases and their regulators in lymphocytes. Nat. Rev. Immunol. 9: 630-644.
19. Faroudi, M., M. Hons, A. Zachacz, C. Dumont, R. Lyck, J. V. Stein, and V. L. Tybulewicz. 2010. Critical roles for Rac GTPases in T-cell migration to and within lymph nodes. Blood 116: 5536-5547.
20. Niggli, V. 1999. Rho-kinase in human neutrophils: a role in signalling for myosin light chain phosphorylation and cell migration. FEBS Lett. 445: 69-72. (Pubitemid 29101537)
21. Mueller, B. K., H. Mack, and N. Teusch. 2005. Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov. 4: 387-398. (Pubitemid 40704122)
22. Vicente-Manzanares, M., X. Ma, R. S. Adelstein, and A. R. Horwitz. 2009. Nonmuscle myosin II takes centre stage in cell adhesion and migration. Nat. Rev. Mol. Cell Biol. 10: 778-790.
23. Worthylake, R. A., and K. Burridge. 2003. RhoA and ROCK promote migration by limiting membrane protrusions. J. Biol. Chem. 278: 13578-13584. (Pubitemid 36800134)
24. Jacobelli, J., S. A. Chmura, D. B. Buxton, M. M. Davis, and M. F. Krummel. 2004. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Nat. Immunol. 5: 531-538. (Pubitemid 38660466)
25. Jacobelli, J., F. C. Bennett, P. Pandurangi, A. J. Tooley, and M. F. Krummel. 2009. Myosin-IIA and ICAM-1 regulate the interchange between two distinct modes of T cell migration. J. Immunol. 182: 2041-2050.
26. Cai, Y., O. Rossier, N. C. Gauthier, N. Biais, M. A. Fardin, X. Zhang, L. W. Miller, B. Ladoux, V. W. Cornish, and M. P. Sheetz. 2010. Cytoskeletal coherence requires myosin-IIA contractility. J. Cell Sci. 123: 413-423.
27. Jacobelli, J., R. S. Friedman, M. A. Conti, A. M. Lennon-Dumenil, M. Piel, C. M. Sorensen, R. S. Adelstein, and M. F. Krummel. 2010. Confine-mentoptimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat. Immunol. 11: 953-961.
28. Worthylake, R. A., S. Lemoine, J. M. Watson, and K. Burridge. 2001. RhoA is required for monocyte tail retraction during transendothelial migration. J. Cell Biol. 154: 147-160. (Pubitemid 34289285)
29. Smith, A., M. Bracke, B. Leitinger, J. C. Porter, and N. Hogg. 2003. LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment. J. Cell Sci. 116: 3123-3133. (Pubitemid 37038961)
30. Morin, N. A., P. W. Oakes, Y. M. Hyun, D. Lee, Y. E. Chin, M. R. King, T. A. Springer, M. Shimaoka, J. X. Tang, J. S. Reichner, and M. Kim. 2008. Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. [Published erratum appears in 2008 J. Exp. Med. 205: 993.] J. Exp. Med. 205: 195-205. (Pubitemid 351185726)
31. Lämmermann, T., B. L. Bader, S. J. Monkley, T. Worbs, R. Wedlich-Söldner, K. Hirsch, M. Keller, R. Förster, D. R. Critchley, R. Fässler, and M. Sixt. 2008. Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature 453: 51-55. (Pubitemid 351630331)
32. Bardi, G., V. Niggli, and P. Loetscher. 2003. Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes. FEBS Lett. 542: 79-83. (Pubitemid 36555718)
33. Xu, H., J. A. Gonzalo, Y. St Pierre, I. R. Williams, T. S. Kupper, R. S. Cotran, T. A. Springer, and J. C. Gutierrez-Ramos. 1994. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J. Exp. Med. 180: 95-109. (Pubitemid 24181059)
34. Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159. (Pubitemid 38094955)
35. Steiner, O., C. Coisne, B. Engelhardt, and R. Lyck. 2011. Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation. J. Cereb. Blood Flow Metab. 31: 315-327.
36. Kopp, H. G., S. T. Avecilla, A. T. Hooper, and S. Rafii. 2005. The bone marrow vascular niche: home of HSC differentiation and mobilization. Physiology (Bethesda) 20: 349-356. (Pubitemid 41457400)
37. Shulman, Z., R. Pasvolsky, E. Woolf, V. Grabovsky, S. W. Feigelson, N. Erez, Y. Fukui, and R. Alon. 2006. DOCK2 regulates chemokine-triggered lateral lymphocyte motility but not transendothelial migration. Blood 108: 2150-2158. (Pubitemid 44497494)
38. Nombela-Arrieta, C., T. R. Mempel, S. F. Soriano, I. Mazo, M. P. Wymann, E. Hirsch, C. Martínez-A, Y. Fukui, U. H. Von Andrian, and J. V. Stein. 2007. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J. Exp. Med. 204: 497-510. (Pubitemid 46457074)
39. Takamatsu, H., N. Takegahara, Y. Nakagawa, M. Tomura, M. Taniguchi, R. H. Friedel, H. Rayburn, M. Tessier-Lavigne, Y. Yoshida, T. Okuno, et al. 2010. Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II. Nat. Immunol. 11: 594-600.
40. Khandoga, A. G., A. Khandoga, C. A. Reichel, P. Bihari, M. Rehberg, and F. Krombach. 2009. In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue. PLoS ONE 4: e4693.