Expression of phosphoryl extracellular signal-regulated kinases in the differentiation of NSCs into neurons induced by the extracts of the fimbria-transected hippocampi in rat

Acta Anatomica Sinica

Volumn 40, Issue 6, 2009, Pages 857-861

  Zhu, Hui Xia ^a,b   Jin, Guo Hua ^a,b,c   Tian, Mei Ling ^a,b,c   Qin, Jian Bing ^a,b,c   Tan, Xue Feng ^a,b,c   Jin, Shu Yi ^a  

^a Jiangsu Key Laboratory of Neuroregeneration   (China)

^b Jiangsu Key Laboratory of Neuroregeneration   (China)

^c NANTONG UNIVERSITY   (China)

Author keywords

Differentiation; Fimbria fornix transected; Hippocampus; Immunofluorescence double labelling; Microtubule associated protein 2; Neural stem cells; Phosphoryl extracellular signal regulated kinases; Rat

Indexed keywords

MICROTUBULE ASSOCIATED PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; CELL COUNT; CELL LABELING; CELL MATURATION; CELL STRUCTURE; CENTRIFUGATION; CONCENTRATION (PARAMETERS); CONTROL GROUP; CONTROLLED STUDY; CULTURE MEDIUM; FETUS; HIPPOCAMPAL FIMBRIA; IMMUNOFLUORESCENCE; NERVE CELL DIFFERENTIATION; NERVE TRANSECTION; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; SUPERNATANT;

RATTUS;

EID: 76149146715     PISSN: 05291356     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.0529-1356.2009.06.002     Document Type: Article

References (17)

1. Zhang XH, Jin GH, Tian ML, et al. Migration of the neural stem cells transplanted into the rat hippocampus [J]. Acta Academia Medicine Nantong, 2002, 22(2): 119-122.
2. Jin GH, Zhang XH, Tian ML, et al. Promoting effect of the extracts from hippocampus in fimbria fornix transection side on the neural stem cells differentiation into neurons[J]. Acta Anatomica Sinica, 2004, 35 (2): 137-141.
3. Tan XF, Jin GH, Tian ML, et al. Isolation, Cloning and differentiation of neural stem cells from human fetal brain [J]. Chinese Journal of Neuroanatomy, 2004, 20(3): 262-266.
4. Shafit-Zagardo B, Kalcheva N. Making sense of the multiple MAP-2 transcripts and their role in the neuron[J]. Mol Neurobiol, 1998, 16 (2): 149-162.
5. Dehmelt L, Halpain S. The MAP2/Tau family of microtubule-associated proteins[J]. Genome Biol, 2004, 6(1): 204.
6. Sharp FR, Liu J, Bernabeu R. Neurogenesis following brain ischemia [J]. Brain Res Dev Brain Res, 2002, 134(1-2): 23-30.
7. Li J. Research progress on exracellular signal-regulated kinase (ERK) signaling pathway[J]. Sichuan Journal of Physiology Science, 2004, 26 (2): 87-89.
8. Norman ED, Thiels E, Barrionuevo G, et al. Long-term depression in the hippocampus in vivo is associated with protein phosphatase-dependent alterations in extracellular signal-regulated kinase [J]. J Neurochem, 2000, 74(1): 192-198.
9. Morozov A, Muzzio IA, Bourtchouladze R, et al. Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory[J]. Neuron, 2003, 39(2): 309-325.
10. Giovannini MG. The role of the extracellular signal-regulated kinase pathway in memory encoding[J]. Rev Neurosci, 2006, 17(6): 619-634.
11. Cowen DS. Serotonin and neuronal growth factors- a convergence of signaling pathways[J]. J Neurochem, 2007, 101(5): 1161-1171.
12. Ménard C, Hein P, Paquin A, et al. An essential role for a MEK-C/ EBP pathway during growth factor-regulated cortical neurogenesis[J]. Neuron, 2002, 36(4): 597-610.
13. Ishikawa Y, Kitamura M. Dual potential of extracellular signal-regulated kinase for the control of cell survival [J]. Biochem Biophys Res Commun, 1999, 264(3): 696-701.
14. Sánchez C, Díaz-Nido J, Avila J. Regulation of a site-specific phosphorylation of the microtubule-associated protein 2 during the development of cultured neurons[J]. Neuroscience, 1998, 87(4): 861-870.
15. Sánchez C, Ledesma D, Dotti CG, et al. Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich region [J]. Neuroscience, 2000, 101 (4): 885-893.
16. Sánchez C, Díaz-Nido J, Avila J, et al. Phosphorylation of microtubule-associated protein-2 (MAP-2) and its relevance for the regulation of the neuronal cytoskeleton function [J]. Prog Neurobiol, 2000, 61(2): 133-168.
17. Iriuchijima N, Sato-Harada R, Takano M, et al. Reduced expression of kinase-associated phosphatase in cortical dendrites of MAP2-deficient mice [J]. Biochem Biophys Res Commun, 2005, 338(2): 1216-1221.