Postmortem drug screening by non-targeted and targeted ultra-performance liquid chromatography-mass spectrometry technology

Journal of Analytical Toxicology

Volumn 35, Issue 7, 2011, Pages 411-423

  Rosano, Thomas G ^a   Wood, Michelle ^b   Swift, Thomas A ^a  

^a ALBANY MEDICAL CENTER   (United States)

^b WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; DEXTROPROPOXYPHENE; DRUG METABOLITE; IMIPRAMINE; METHADONE; METHAPYRILENE; MORPHINE; NORDAZEPAM; PHENCYCLIDINE;

ACCURACY; ADULT; ARTICLE; AUTOPSY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; FEMALE; FRAGMENTATION REACTION; HUMAN; LIBRARY SCIENCE; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; REPRODUCIBILITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY;

EID: 80052627408     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/anatox/35.7.411     Document Type: Article

References (23)

1. L.J. Josephs. Characterization of over-the-counter cough/cold medications by liquid chromatography/electrospray mass spectrometry. Rapid Commun. Mass Spectrom. 9: 1270-1274 (1995).
2. P. Marquet, N. Venisse, É. Lacassie, and G. Lachâtre. In-source CID mass spectral libraries for the 'general unknown screening of drugs and toxicants. Analusis 28: 925-934 (2000).
3. J.M. Hough, C.A Haney, R.D.Voyksner, and R.D. Bereman. Evaluation of electrospray transport CID for the generation of searchable libraries. Anal. Chem. 72: 2265-2270 (2000).
4. A. Schreiber, J. Efer, andW. Englewald. Application of spectral libraries for high-performance liquid chromatography-atmospheric pressure ionisation mass spectrometry to the analysis of pesticide and explosive residues in the environment. J. Chromatogr. A 869: 411-425 (2000).
5. W. Weinmann, M. Stoertzel, S. Vogt, and J. Wendt. Tune compounds for electrospray ionization/in-source collision-induced dissociation with mass spectral library searching. J. Chromatogr. A 926: 199-209 (2001).
6. W. Weinmann, A. Weidemann, B. Eppinger, and M. Renz. Screening for drugs in serum by electrospray ionization/collision-induced dissociation and library searching. Am. Soc. Mass Spectrom. 10: 1028-1037 (1999).
7. L. Humbert, F. Grisel, C. Richeval, and M. Lhermitte. Screening of xenobiotics by ultra-performance liquid chromatography-mass spectrometry using in-source fragmentation at increasing cone voltages: library constitution and an evaluation of spectral stability. J. Anal. Toxicol. 34: 1-10 (2010).
8. W. Weinmann, N. Lehmann, M. Renz, A. Wiedemann, and M. Svoboda. Screening for drugs in serum and urine by LC/ESI/CID-MS and MS/MS with library searching. J. Forensic Sci. 42: 202-208 (2000).
9. M. Gergov, I. Ojanperä, and E. Vuori. Simultaneous screening for 238 drugs in blood by liquid chromatography-ionspray tandem mass spectrometry with multiple-reaction monitoring. J. Chromatogr. B 795: 41-53 (2003).
10. P. Marquet, F. Saint-Marcoux, T.N. Gamble, and J.C.Y. Leblanc. Comparison of a preliminary procedure for the general unknown screening of drugs and toxic compounds using a quadrupolelinear ion-trap mass spectrometer with a liquid chromatography-mass spectrometry reference technique. J. Chromatogr. B 789: 9-18 (2003).
11. C.A. Mueller, W. Weinmann, S. Dresen, A. Schreiber, and M. Gergov. Development of a multi-target screening analysis for 301 drugs using a QTrap liquid chromatography/tandem mass spectrometry system and automated library search. Rapid Commun. Mass Spectrom. 19: 1332-1338 (2005).
12. S. Dresen, J. Kempf, and W. Weinmann. Electrospray-ionization MS/MS library of drugs as database for method development and drug identification. Forensic Sci. Int. 166: 86-91 (2006).
13. F.-L. Sauvage, F Saint-Marcoux, B. Duretz, D. Deporte, G. Lachâtre, and P. Marquet. Screening of drugs and toxic compounds with liquid chromatography-linear ion trap tandem mass spectrometry. Clin. Chem. 52: 1735-1742 (2006).
14. S. Dresen, N. Ferreirós, H. Gnann, and R. Zimmermann. Detection and identification of 700 drugs by multi-target screening with a 3200 Q TRAP LC-MS/MS system and library searching. Anal. Bioanal. Chem. 396: 2425-2434 (2010).
15. S. Dresen, M. Gergov, L. Politi, C. Halter, and W. Weinmann. ESI-MS/MS library of 1,253 compounds for application in forensic and clinical toxicology. Anal. Bioanal. Chem. 395: 2521-2526 (2009).
16. F. Saint-Marcoux, G. Lachâtre, and P. Marquet. Evaluation of an improved general unknown screening procedure using liquidchromatography-electrospray-mass spectrometry by comparison with gas chromatography and high-performance liquid-chromatography-diode array detection. J.Am. Soc.Mass Spectrom. 14: 14-22 (2003).
17. G.L. Herrin, H.H. McCurdy, and W.H. Wall. Investigation of an LC-MS-MS (QTrap) method for the rapid screening and identification of drugs in postmortem toxicology whole blood samples. J. Anal. Toxicol. 29: 599-606 (2005).
18. European Union Decision2002/657/EC 17.8.2002. Off. J. Eur. Commun. 221: 8-36 (2002).
19. L. Rivier. Criteria for the identification of compounds by liquid chromatography-mass spectrometry and liquid chromatography-multiple mass spectrometry in forensic toxicology and doping analysis. Anal. Chim. Acta 492: 69-82 (2003).
20. E. Chambers, D.M. Wagrowski-Diehl, Z. Lu, and J.R. Mazzeo. Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses. J. Chromatogr. B 852: 22-34 (2007).
21. C. Müller, P. Schäfer, M. Störtzel, S. Vogt, andW.Weinmann. Ion suppression effects in liquid-electrospray-ionization transport region collision induced dissociation mass spectrometry with different serum extraction methods for systematic toxicological analysis with mass spectra libraries. J. Chromatogr. B 733: 47-52 (2002).
22. R. Diems, M.A. Huestis,W.E. Lambert, and C.M. Murphy. Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: influence of ionization type, sample preparation, and biofluid. J. Am. Soc. Mass Spectrom. 14: 1290-1294 (2003).
23. E. Saar, D. Gerostamoulos, and O.H. Drummer. Comparison of extraction efficiencies and LC-MS-MS matrix effects using LLE and SPE methods for 19 antipsychotics in human blood. Anal. Bioanal. Chem. 393: 727-734 (2009).