Synthesis of 4′-ethynyl-2′-deoxy-4′-thioribonucleosides and discovery of a highly potent and less toxic NRTI

ACS Medicinal Chemistry Letters

Volumn 2, Issue 9, 2011, Pages 692-697

  Haraguchi, Kazuhiro ^a   Shimada, Hisashi ^a   Kimura, Keigo ^a   Akutsu, Genta ^a   Tanaka, Hiromichi ^a   Abe, Hiroshi ^b   Hamasaki, Takayuki ^c   Baba, Masanori ^c   Gullen, Elizabeth A ^d   Dutschman, Ginger E ^d   Cheng, Yung Chi ^d   Balzarini, Jan ^e  

^a SHOWA UNIVERSITY   (Japan)

^b RIKEN   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

4 Thionucleosides; anti HIV 1 activity; electrophilic glycosidation; glycal; nucleoside reverse transcriptaseinhibitors

Indexed keywords

4' ETHYNYL 2' DEOXY 4' THIORIBONUCLEOSIDE; ADENINE; CYTOSINE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; ELECTROPHILICITY; GLYCOSIDATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80052616126     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2001054     Document Type: Article

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