Binding Studies and Quantitative Structure-Activity Relationship of 3-Amino-1H-Indazoles as Inhibitors of GSK3β

Chemical Biology and Drug Design

Volumn 78, Issue 4, 2011, Pages 631-641

  Caballero, Julio ^a   Zilocchi, Szymon ^b,c   Tiznado, William ^c   Collina, Simona ^b   Rossi, Daniela ^b  

^a UNIVERSIDAD DE TALCA   (Chile)

^b UNIVERSITY OF PAVIA   (Italy)

^c UNIVERSIDAD ANDRÉS BELLO   (Chile)

Author keywords

CoMSIA; Glycogen synthase kinase; GSK3 ; Molecular docking; Quantitative structure activity relationships

Indexed keywords

3 AMINO 1H INDAZOLE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; INDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; COMPUTER MODEL; COMPUTER PROGRAM; ENZYME ACTIVE SITE; HINGE REGION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN BINDING; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BINDING SITES; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDAZOLES; MODELS, MOLECULAR; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052614834     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01186.x     Document Type: Article

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