Adipogenic differentiation alters the immunoregulatory property of mesenchymal stem cells through BAFF secretion

Hematology

Volumn 16, Issue 5, 2011, Pages 313-323

  Wang, Haiyan ^a   Chen, Tong ^a   Ding, Tianling ^a   Zhu, Ping ^a   Xu, Xiaoping ^a   Yu, Long ^b   Xie, Yi ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Adipogenic differentiation; Costimulation; Immunoregulatory; Lymphocytes; Mesenchymal stem cell

Indexed keywords

B CELL ACTIVATING FACTOR; GAMMA INTERFERON; IMMUNOGLOBULIN; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL DIFFERENTIATION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; SUPERNATANT; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ADIPOGENESIS; ANIMALS; B-CELL ACTIVATING FACTOR; BONE MARROW CELLS; CELL PROLIFERATION; CELLS, CULTURED; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; LYMPHOCYTES; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL;

EID: 80052601265     PISSN: 10245332     EISSN: 16078454     Source Type: Journal    
DOI: 10.1179/102453311X13085644679944     Document Type: Article

References (40)

1. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-7.
2. Di Nicola M, Carlo-Stella C, Magni M, Milanesi M, Longoni PD, Matteucci P, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002;99:3838-43.
3. Le Blanc K, Tammik L, Sundberg B, Haynesworth, SE, Ringdén O. Mesenchymal stem cells inhibit and stimulate mixed lymphocyte cultures and mitogenic responses independently of the major histocompatibility complex. Scand J Immunol 2003;57:11-20.
4. Aggarwal S, Pittenger M. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005;105: 1815-22.
5. Beyth S, Borovsky Z, Mevorach D, Liebergall M, Gazit Z, Aslan H, et al. Human mesenchymal stem cells alter antigenpresenting cell maturation and induce T cell unresponsiveness. Blood 2005;105:2214-9.
6. Corcione A, Benvenuto F, Ferretti E, Giunti D, Cappiello V, Cazzanti F, et al. Human mesenchymal stem cells modulate Bcell functions. Blood 2006;107:367-72.
7. Spaggiari GM, Capobianco A, Becchetti S, Mingari MC, Moretta L. Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 2006;107:1484-90.
8. Sotiropoulou PA, Perez SA, Gritzapis AD, Baxevanis CN, Papamichail M. Interactions between human mesenchymal stem cells and natural killer cells. Stem Cells 2006;24:74-85.
9. Jiang XX, Zhang Y, Liu B, Zhang SX, Wu Y, Yu XD, et al. Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 2005; 105:4120-6.
10. Ramasamy R, Fazekasova H, Lam EW, Soeiro I, Lombardi G, Dazzi F. Mesenchymal stem cells inhibit dendritic cell differentiation and function by preventing entry into the cell cycle. Transplantation 2007;83:71-6.
11. Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E et al.: Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide. Blood 2003, 101, 3722-3729.
12. Potian JA, Aviv H, Ponzio NM, Harrison JS, Rameshwar P.: Veto-like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens. J Immunol 2003, 171, 3426-3434.
13. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC.: Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implications in transplantation. Transplantation 2003, 75, 389-397.
14. Djouad F, Plence P, Bony C, Tropel P, Apparailly F, Sany J, et al. Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals. Blood 2003;102:3837-44.
15. Meisel R, Zibert A, Laryea M, Gobel U, Daubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase- mediated tryptophan degradation. Blood 2004;103:4619-21.
16. Bartholomew A, Sturgeon C, Siatskas M, Ferrer K, McIntosh K, Patil S, et al. Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 2002;30:42-8.
17. Lazarus HM, Koc ON, Devine SM, Curtin P, Maziarz RT, Holland HK, et al. Cotransplantation of HLA-identical sibling culture- expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant 2005;11:389-98.
18. Le Blanc K, Rasmusson I, Sundberg B, Götherström C, Hassan M, Uzunel M, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004;363:1439-41.
19. Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T cell anergy. Blood 2005;106:1755-61.
20. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci USA 2002;99:8932-7.
21. Koc ON, Day J, Nieder M, Gerson SL, Lazarus HM, Krivit W. Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH). Bone Marrow Transplant 2002;30:215-22.
22. Koc ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol 2000;18:307-16.
23. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AB, Deans R, et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000;6:1282-6.
24. MacDonald DJ, Luo J, Saito T, Duong M, Bernier PL, Chiu RC, et al. Persistence of marrow stromal cells implanted into acutely infarcted myocardium: Observations in a xenotransplant model. J Thorac Cardiovasc Surg 2005;130:1114-21.
25. Grinnemo KH, Mansson A, Dellgren G, Klingberg D, Wardell E, Drvota V, et al. Xenoreactivity and engraftment of human mesenchymal stem cells transplanted into infarcted rat myocardium. J Thorac Cardiovasc Surg 2004;127:1293-300.
26. Fantuzzi G. Adipose tissue, adipokines and inflammation. J Allergy Clin Immunol 2005;115:911-9.
27. Kim YH, Choi BH, Do MS. The interaction of adipose tissue with immune system and related inflammatory molecules. Immune Network 2006;6:169-78.
28. Tilg H, Moschen AR. Adipokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-83.
29. Kim YH, Choi BH, Cheon HG, Do MS. B cell activation factor (BAFF) is a novel adipokine that links obesity and inflammation. Exp Mol Med 2009;41:208-16.
30. Do MS, Jeong HS, Choi BH, Hunter L, Langley S, Pazmany L, et al. Inflammatory gene expression patterns revealed by DNA microarray anaysis in TNF-a-treated SGBS human adipocytes. Yonsei Med J 2006;47:729-36.
31. Rasmusson I. Immune modulation by mesenchymal stem cells. Exp Cell Res 2006;312:2169-79.
32. Uccelli A, Moretta L, Pistoia V. Immunoregulatory function of mesenchymal stem cells. Eur J Immunol 2006;36:2566-73.
33. Chen X, McClurg A, Zhou GQ, McCaigue M, Armstrong MA, Li G. Chondrogenic differentiation alters the immunosuppressive property of bone marrow-derived mesenchymal stem cells, and the effect is partially due to the upregulated expression of B7 molecules. Stem Cells 2007;25:364-70.
34. Deans RJ, Moseley AB. Mesenchymal stem cells: biology and potential clinical uses. Exp Hematol 2000;28:875-84.
35. Tse WT, Beyer W, Pendleton JD, D'Andrea A, Guinan EC. Bone marrow derived mesenchymal stem cells suppress T cell activation without inducing allogeneic anergy. Blood 2000;96:1034a.
36. Huard B, Schneider P, Mauri D, Tschopp J, French LE. T cell co-stimulation by the TNF ligand BAFF. J Immunol 2001;167:6225-31.
37. Ng LG, Sutherland AP, Newton R, Qian F, Cachero TG, Scott ML, et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 2004; 173:807-17.
38. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999; 189:1747-56.
39. Tran TT, Kahn CR. Transplantation of adipose tissue and stem cells: role in metabolism and disease. Nat Rev Endocrinol 2010;6:195-213.
40. Maitra B, Szekely E, Gjini K, Laughlin MJ, Dennis J, Haynesworth SE, et al. Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant 2004;33:597-604.