POMC overexpression in the ventral tegmental area ameliorates dietary obesity

Journal of Endocrinology

Volumn 210, Issue 2, 2011, Pages 199-207

  Andino, Lourdes M ^a   Ryder, Daniel J ^a   Shapiro, Alexandra ^a   Matheny, Michael K ^a   Zhang, Yi ^a,b   Judge, Melanie K ^a   Cheng, K Y ^a   Tümer, Nihal ^a,b   Scarpace, Philip J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; PROOPIOMELANOCORTIN; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; FOOD INTAKE; GENE OVEREXPRESSION; MELANOCYTE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; VENTRAL TEGMENTUM; WEIGHT GAIN; ANIMAL; ARCUATE NUCLEUS; BROWN ADIPOSE TISSUE; EATING; FAT INTAKE; GENE TRANSFER; GENETICS; METABOLISM; PHYSIOLOGY;

ADIPOSE TISSUE, BROWN; ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; DIETARY FATS; EATING; GENE TRANSFER TECHNIQUES; ION CHANNELS; MITOCHONDRIAL PROTEINS; OBESITY; OXYGEN CONSUMPTION; PRO-OPIOMELANOCORTIN; RATS; VENTRAL TEGMENTAL AREA;

EID: 80052601264     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-10-0418     Document Type: Article

References (37)

1. Alvaro JD, Tatro JB, Quillan JM, Fogliano M, Eisenhard M, Lerner MR, Nestler EJ & Duman RS 1996 Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Molecular Pharmacology 50 583-591.
2. Andino LM, Takeda M, Kasahara H, Jakymiw A, Byrne BJ & Lewin AS 2008 AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes. Journal of Gene Medicine 10 132-142.
3. de Backer MW, la Fleur SE, Brans MA, van Rozen AJ, Luijendijk MC, Merkestein M, Garner KM, van der Zwaal EM & Adan RA 2010 Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions. International Journal of Obesity 35 629-641.
4. Balthasar N 2006 Genetic dissection of neuronal pathways controlling energy homeostasis. Obesity 14 (Suppl 5) 222S-227S.
5. Benjannet S, Rondeau N, Day R, Chretien M & Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. PNAS 88 3564-3568.
6. Berns KI & Giraud C 1996 Biology of adeno-associated virus. Current Topics in Microbiology and Immunology 218 1-23.
7. Cannon B & Nedergaard J 2004 Brown adipose tissue: function and physiological significance. Physiological Reviews 84 277-359.
8. Cearley CN &Wolfe JH 2007 A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. Journal of Neuroscience 27 9928-9940.
9. Cone RD 2005 Anatomy and regulation of the central melanocortin system. Nature Neuroscience 8 571-578.
10. DeBold CR, Menefee JK, Nicholson WE & Orth DN 1988 Proopiomelanocortin gene is expressed in many normal human tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Molecular Endocrinology 2 862-870.
11. Fluharty SJ, Snyder GL, Zigmond MJ & Stricker EM 1985 Tyrosine hydroxylase activity and catecholamine biosynthesis in the adrenal medulla of rats during stress. Journal of Pharmacology and Experimental Therapeutics 233 32-38.
12. Garfield AS, Lam DD, Marston OJ, Przydzial MJ & Heisler LK 2009 Role of central melanocortin pathways in energy homeostasis. Trends in Endocrinology and Metabolism 20 203-215.
13. Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A et al. 2005 Agouti-related peptideexpressing neurons are mandatory for feeding. Nature Neuroscience 8 1289-1291.
14. Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M & DiLeone RJ 2006 Leptin receptor signaling in midbrain dopamine neurons regulates feeding. Neuron 51 801-810.
15. Judge MK, Zhang J, Tumer N, Carter C, Daniels MJ & Scarpace PJ 2008 Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 295 R773-R780.
16. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB & Elmquist JK 2003 Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. Journal of Comparative Neurology 457 213-235.
17. Lasaga M, Debeljuk L, Durand D, Scimonelli TN & Caruso C 2008 Role of alpha-melanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides 29 1825-1835.
18. Lee M, Kim A, Chua SC Jr, Obici S & Wardlaw SL 2007 Transgenic MSH overexpression attenuates the metabolic effects of a high-fat diet. American Journal of Physiology. Endocrinology and Metabolism 293 E121-E131.
19. Leibowitz SF 1970 Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus. PNAS 67 1063-1070.
20. Leriche M, Cote-Velez A & Mendez M 2007 Presence of proopiomelanocortin mRNA in the rat medial prefrontal cortex, nucleus accumbens and ventral tegmental area: studies by RT-PCR and in situ hybridization techniques. Neuropeptides 41 421-431.
21. Li G, Mobbs CV & Scarpace PJ 2003 Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52 1951-1957.
22. Li G, Zhang Y, Wilsey JT & Scarpace PJ 2004 Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. Journal of Endocrinology 182 123-132.
23. Li G, Zhang Y, Wilsey JT & Scarpace PJ 2005 Hypothalamic proopiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Diabetologia 48 2376-2385.
24. Li G, Zhang Y, Cheng KY & Scarpace PJ 2007 Lean rats with hypothalamic pro-opiomelanocortin overexpression exhibit greater diet-induced obesity and impaired central melanocortin responsiveness. Diabetologia 50 1490-1499.
25. Lindblom J, Opmane B, Mutulis F, Mutule I, Petrovska R, Klusa V, Bergstrom L & Wikberg JE 2001 The MC4 receptor mediates alpha-MSH induced release of nucleus accumbens dopamine. Neuroreport 12 2155-2158.
26. Lu L, Wang X, Wu P, Xu C, Zhao M, Morales M, Harvey BK, Hoffer BJ & Shaham Y 2009 Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving. Biological Psychiatry 66 137-145.
27. Luquet S, Phillips CT & Palmiter RD 2007 NPY/AgRP neurons are not essential for feeding responses to glucoprivation. Peptides 28 214-225.
28. Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, FoustKD, ZhangY,MuzyczkaNet al. 2009Nigrostriatal rAAV-mediated GDNFoverexpression induces robustweight loss in a rat model of age-related obesity. Molecular Therapy 17 980-991.
29. Mayer J & Thomas DW 1967 Regulation of food intake and obesity. Science 156 328-337.
30. McCarty DM, Monahan PE & Samulski RJ 2001 Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Therapy 8 1248-1254.
31. Morton GJ, Blevins JE, Kim F, Matsen M& Figlewicz DP 2009 The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling. American Journal of Physiology. Endocrinology and Metabolism 297 E202-E210.
32. Muzyczka N 1992 Use of adeno-associated virus as a general transduction vector for mammalian cells. Current Topics in Microbiology and Immunology 158 97-129.
33. Savontaus E, Breen TL, Kim A, Yang LM, Chua SC Jr & Wardlaw SL 2004 Metabolic effects of transgenic melanocyte-stimulating hormone overexpression in lean and obese mice. Endocrinology 145 3881-3891.
34. Scarpace PJ, Matheny M, Zolotukhin S, Tumer N & Zhang Y 2003 Leptininduced leptin resistant rats exhibit enhanced responses to the melanocortin agonist MT II. Neuropharmacology 45 211-219.
35. Seeley RJ, BurklowML, Wilmer KA, Matthews CC, ReizesO, McOsker CC, Trokhan DP, Gross MC & Sheldon RJ 2005 The effect of the melanocortin agonist, MT-II, on the defended level of body adiposity. Endocrinology 146 3732-3738.
36. Spector S, Sjoerdsma A & Udenfriend S 1965 Blockade of endogenous norepinephrine synthesis by alpha-methyl-tyrosine, an inhibitor of tyrosine hydroxylase. Journal of Pharmacology and Experimental Therapeutics 147 86-95.
37. Tinsley FC, Taicher GZ & Heiman ML 2004 Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis. Obesity Research 12 150-160.