Fliposomes: pH-sensitive liposomes containing a trans-2-morpholinocyclohexanol-based lipid that performs a conformational flip and triggers an instant cargo release in acidic medium

Pharmaceutics

Volumn 3, Issue 3, 2011, Pages 379-405

  Samoshina, Nataliya M ^a   Liu, Xin ^a   Brazdova, Barbora ^a   Franz, Andreas H ^a   Samoshin, Vyacheslav V ^a   Guo, Xin ^a  

^a UNIVERSITY OF THE PACIFIC   (United States)

Author keywords

Conformational switch; Controlled drug release; Fliposomes; pH sensitive liposomes; Polyethyleneglycol (PEG); Triggered release

Indexed keywords

2 MORPHOLINOCYCLOHEXANOL; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; 4 XYLENE BIS PYRIDINIUM BROMIDE; 8 AMINONAPHTHALENE 1,3,6 TRISULFONIC ACID DISODIUM SALT; AMPHOPHILE; CERAMIDE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; FLIPOSOME; FLUORESCENT DYE; LIPOSOME; MACROGOL; METHOTREXATE; PYRIDINIUM DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONFORMATIONAL TRANSITION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG STABILITY; DRUG STORAGE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID COMPOSITION; LIPOSOMAL DELIVERY; PROTON NUCLEAR MAGNETIC RESONANCE; STORAGE TEMPERATURE; UTERINE CERVIX CANCER;

EID: 80052588375     PISSN: None     EISSN: 19994923     Source Type: Journal    
DOI: 10.3390/pharmaceutics3030379     Document Type: Article

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