Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 4, 2011, Pages 374-386

  Sasaki, Tomohiro ^a   Hirota, Takeshi ^a   Ryokai, Yuriko ^a   Kobayashi, Daisuke ^a   Kimura, Miyuki ^b   Irie, Shin ^b   Higuchi, Shun ^a   Ieiri, Ichiro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Kyushu Clinical Pharmacology Research Clinic   (Japan)

Author keywords

ABCC3; Drug transporter; Human; MRP3; Pharmacogenomics; Pharmacokinetics; Polymorphism

Indexed keywords

ARGININE; CYSTEINE; GLUTAMINE; HISTIDINE; HYMECROMONE GLUCURONIDE; LEUCINE; LUCIFERASE; MESSENGER RNA; TRYPTOPHAN;

ABCC3 GENE; ADULT; AFRICAN AMERICAN; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DNA FLANKING REGION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; ETHNIC DIFFERENCE; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; JAPANESE; MALE; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 3 GENE; NONSENSE MUTATION; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; PROMOTER REGION; REPORTER GENE; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSCRIPTION REGULATION; WILD TYPE;

EID: 80052587951     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-103     Document Type: Article

References (23)

1. Kool, M., de Haas, M., Scheffer., G. L., Scheper, R. J., van Eijk, M. J., Juijn, J. A., Baas, F. and Borst, P.: Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res., 57: 3537-3547 (1997).
2. Borst, P., Evers, R., Kool, M. and Wijnholds, J.: The multidrug resistance protein family. Biochim. Biophys. Acta, 1461: 347-357 (1999).
3. König, J., Rost, D., Cui, Y. and Keppler, D.: Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology, 29: 1156-1163 (1999).
4. Inokuchi, A., Hinoshita, E., Iwamoto, Y., Kohno, K., Kuwano, M. and Uchiumi, T.: Enhanced expression of the human multidrug resistance protein 3 by bile salt in human enterocytes. A transcriptional control of a plausible bile acid transporter. J. Biol. Chem., 276: 46822-46829 (2001).
5. Hirohashi, T., Suzuki, H. and Sugiyama, Y.: Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3). J. Biol. Chem., 274: 15181-15185 (1999).
6. Kitamura, Y., Kusuhara, H. and Sugiyama, Y.: Functional characterization of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine. J. Pharmacol. Exp. Ther., 332: 659-666 (2010).
7. Zamek-Gliszczynski, M. J., Nezasa, K., Tian, X., Bridges, A. S., Lee, K., Belinsky, M. G., Kruh, G. D. and Brouwer, K. L.: Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3%/% and Abcc4%/% mice. J. Pharmacol. Exp. Ther., 319: 1485-1491 (2006).
8. Hirouchi, M., Kusuhara, H., Onuki, R., Ogilvie, B. W., Parkinson, A. and Sugiyama, Y.: Construction of triple-transfected cells [organic anion-transporting polypeptide (OATP) 1B1/multidrug resistance-associated protein (MRP) 2/MRP3 and OATP1B1/ MRP2/MRP4] for analysis of the sinusoidal function of MRP3 and MRP4. Drug Metab. Dispos., 37: 2103-2111 (2009).
9. Kitamura, Y., Hirouchi, M., Kusuhara, H., Schuetz, J. D. and Sugiyama, Y.: Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3). J. Pharmacol. Exp. Ther., 327: 465-473 (2008).
10. Tian, X., Swift, B., Zamek-Gliszczynski, M. J., Belinsky, M. G., Kruh, G. D. and Brouwer, K. L.: Impact of basolateral multidrug resistance-associated protein (Mrp) 3 and Mrp4 on the hepatobiliary disposition of fexofenadine in perfused mouse livers. Drug Metab. Dispos., 36: 911-915 (2008).
11. Hitzl, M., Klein, K., Zanger, U. M., Fritz, P., Nüssler, A. K., Neuhaus, P. and Fromm, M. F.: Influence of omeprazole on multidrug resistance protein 3 expression in human liver. J. Pharmacol. Exp. Ther., 304: 524-530 (2003).
12. Müller, P. J., Dally, H., Klappenecker, C. N., Edler, L., Jäger, B., Gerst, M., Spiegelhalder, B., Tuengerthal, S., Fischer, J. R., Drings, P., Bartsch, H. and Risch, A.: Polymorphisms in ABCG2, ABCC3 and CNT1 genes and their possible impact on chemotherapy outcome of lung cancer patients. Int. J. Cancer, 124: 1669-1674 (2009).
13. Hirota, T., Ieiri, I., Takane, H., Maegawa, S., Hosokawa, M., Kobayashi, K., Chiba, K., Nanba, E., Oshimura, M., Sato, T., Higuchi, S. and Otsubo, K.: Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status. Hum. Mol. Genet., 13: 2959-2969 (2004).
14. Garrett, E. R., Venitz, J., Eberst, K. and Cerda, J. J.: Pharmacokinetics and bioavailabilities of hymecromone in human volunteers. Biopharm. Drug Dispos., 14: 13-39 (1993).
15. Lang, T., Hitzl, M., Burk, O., Mornhinweg, E., Keil, A., Kerb, R., Klein, K., Zanger, U. M., Eichelbaum, M. and Fromm, M. F.: Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver. Pharmacogenetics, 14: 155-164 (2004).
16. Fukushima-Uesaka, H., Saito, Y., Maekawa, K., Hasegawa, R., Suzuki, K., Yanagawa, T., Kajio, H., Kuzuya, N., Noda, M., Yasuda, K., Tohkin, M. and Sawada, J.: Genetic variations of the ABC transporter gene ABCC3 in a Japanese population. Drug Metab. Pharmacokinet., 22: 129-135 (2007).
17. Chayka, O., Kintscher, J., Braas, D. and Klempnauer, K. H.: v-Myb mediates cooperation of a cell-specific enhancer with the mim-1 promoter. Mol. Cell. Biol., 25: 499-511 (2005).
18. Gradhand, U., Tegude, H., Burk, O., Eichelbaum, M., Fromm, M. F. and König, J.: Functional analysis of the polymorphism %211ChT in the regulatory region of the human ABCC3 gene. Life Sci., 80: 1490-1494 (2007).
19. Zamek-Gliszczynski, M. J., Hoffmaster, K. A., Humphreys, J. E., Tian, X., Nezasa, K. and Brouwer, K. L. R.: Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat. J. Pharmacol. Exp. Ther., 319: 459-467 (2006).
20. Müller, P., Asher, N., Heled, M., Cohen, S. B., Risch, A. and Rund, D.: Polymorphisms in transporter and phase II metabolism genes as potential modifiers of the predisposition to and treatment outcome of de novo acute myeloid leukemia in Israeli ethnic groups. Leuk. Res., 32: 919-929 (2008).
21. Liu, Y., Peng, H. and Zhang, J. T.: Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray. Mol. Pharmacol., 68: 430-438 (2005).
22. Hanada, S., Maeshima, A., Matsuno, Y., Ohta, T., Ohki, M., Yoshida, T., Hayashi, Y., Yoshizawa, Y., Hirohashi, S. and Sakamoto, M.: Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression. J. Pathol., 216: 75-82 (2008).
23. OöBrien, C., Cavet, G., Pandita, A., Hu, X., Haydu, L., Mohan, S., Toy, K., River, C. S., Modrusan, Z., Amler, L. C. and Lackner, M. R.: Functional genomics identifies ABCC3 as a mediator of taxane resistance in HER2-amplified breast cancer. Cancer Res., 68: 5380-5389 (2008).