Simultaneous GC-MS determination of nicotine and cotinine in plasma for the pharmacokinetic characterization of nicotine in rats

Journal of Pharmaceutical and Biomedical Analysis

Volumn 20, Issue 1-2, 1999, Pages 195-202

  Jung, Byung Hwa ^a,b   Chung, Bong Chul ^b   Chung, Suk Jae ^a   Lee, Min Hwa ^a   Shim, Chang Koo ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Cotinine; Extraction; GC MSD; Nicotine; Pharmacokinetics

Indexed keywords

COTININE; NICOTINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; GAS CHROMATOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; COTININE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; MALE; NICOTINIC AGONISTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 0033004403     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(99)00020-5     Document Type: Article

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