The insulin-like growth factor 1 pathway is a potential therapeutic target for low-grade serous ovarian carcinoma

Gynecologic Oncology

Volumn 123, Issue 1, 2011, Pages 13-18

  King, Erin R ^a   Zu, Zhifei ^a   Tsang, Yvonne T M ^a   Deavers, Michael T ^a   Malpica, Anais ^a   Mok, Samuel C ^a   Gershenson, David M ^a   Wong, Kwong Kwok ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Insulin receptor; Insulin like growth factor; Ovarian cancer

Indexed keywords

LINSITINIB; MESSENGER RNA; MK 2206; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; RECOMBINANT SOMATOMEDIN C; SHORT HAIRPIN RNA; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; OVARY CARCINOMA; OVARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROUS BORDERLINE OVARY TUMOR; SEROUS OVARY CARCINOMA; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; UPREGULATION; WESTERN BLOTTING;

CELL GROWTH PROCESSES; CELL LINE, TUMOR; CYSTADENOCARCINOMA, SEROUS; FEMALE; GENE EXPRESSION PROFILING; GENE KNOCKDOWN TECHNIQUES; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; IMIDAZOLES; INSULIN-LIKE GROWTH FACTOR I; MOLECULAR TARGETED THERAPY; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZINES; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 80052583874     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.06.016     Document Type: Article

References (32)

1. M.M. Woo, C.M. Salamanca, and M. Miller Serous borderline ovarian tumors in long-term culture: phenotypic and genotypic distinction from invasive ovarian carcinomas Int J Gynecol Cancer 18 2008 1234 1247
2. T. Bonome, J.Y. Lee, and D.C. Park Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary Cancer Res 65 2005 10602 10612 (Pubitemid 41743756)
3. I.M. Shih, L. Chen, and C.C. Wang Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis Am J Obstet Gynecol 203 2010 584e1 584e22
4. R.J. Kurman, and I. Shih The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory Am J Surg Pathol 34 2010 433 443
5. M.A. Crispens, D. Bodurka, and M. Deavers Response and survival in patients with progressive or recurrent serous ovarian tumors of low malignant potential Obstet Gynecol 99 2002 3 10 (Pubitemid 34075460)
6. D.M. Gershenson, E.G. Silva, and G. Tortolero-Luna Serous borderline tumors of the ovary with noninvasive peritoneal implants Cancer 83 1998 2157 2163 (Pubitemid 28525397)
7. C. Uzan, A. Kane, and A. Rey How to follow up advanced-stage borderline tumours? Mode of diagnosis of recurrence in a large series stage II-III serous borderline tumours of the ovary Ann Oncol 22 2011 631 635
8. G. Singer, R.J. Kurman, and H.W. Chang Diverse tumorigenic pathways in ovarian serous carcinoma Am J Pathol 160 2002 1223 1228 (Pubitemid 34411626)
9. A. Malpica, M.T. Deavers, and K. Lu Grading ovarian serous carcinoma using a two-tier system Am J Surg Pathol 28 2004 496 504 (Pubitemid 38436523)
10. A. Malpica, M.T. Deavers, and C. Tornos Interobserver and intraobserver variability of a two-tier system for grading ovarian serous carcinoma Am J Surg Pathol 31 2007 1168 1174 (Pubitemid 47207118)
11. D.M. Gershenson, C.C. Sun, and K.H. Lu Clinical behavior of stage II-IV low-grade serous carcinoma of the ovary Obstet Gynecol 108 2006 361 368 (Pubitemid 44305678)
12. H.S. Shvartsman, C.C. Sun, and D.C. Bodurka Comparison of the clinical behavior of newly diagnosed stages II-IV low-grade serous carcinoma of the ovary with that of serous ovarian tumors of low malignant potential that recur as low-grade serous carcinoma Gynecol Oncol 105 2007 625 629 (Pubitemid 46734181)
13. D.M. Gershenson, C.C. Sun, and D. Bodurka Recurrent low-grade serous ovarian carcinoma is relatively chemoresistant Gynecol Oncol 114 2009 48 52
14. K.M. Schmeler, C.C. Sun, and D.C. Bodurka Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum Gynecol Oncol 108 2008 510 514
15. A.J. Levine, Z. Feng, and T.W. Mak Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways Genes Dev 20 2006 267 275 (Pubitemid 43200281)
16. K. Scotlandi, and P. Picci Targeting insulin-like growth factor 1 receptor in sarcomas Curr Opin Oncol 20 2008 419 427
17. T.A. Longacre, J.K. McKenney, and H.D. Tazelaar Ovarian serous tumors of low malignant potential (borderline tumors): outcome-based study of 276 patients with long-term (> or = 5-year) follow-up Am J Surg Pathol 29 2005 707 723 (Pubitemid 40734421)
18. M. Shih Ie, and R.J. Kurman Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges Clin Cancer Res 11 2005 7273 7279 (Pubitemid 41507684)
19. G. Pohl, C.L. Ho, and R.J. Kurman Inactivation of the mitogen-activated protein kinase pathway as a potential target-based therapy in ovarian serous tumors with KRAS or BRAF mutations Cancer Res 65 2005 1994 2000 (Pubitemid 40478629)
20. R.N. Buick, R. Pullano, and J.M. Trent Comparative properties of five human ovarian adenocarcinoma cell lines Cancer Res 45 1985 3668 3676 (Pubitemid 15226443)
21. K.K. Wong, Y.M. Chang, and Y.T. Tsang Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups Cancer Res 65 2005 76 84 (Pubitemid 40070797)
22. K.S. McCarty Jr., E. Szabo, and J.L. Flowers Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors Cancer Res 46 1986 4244s 4248s (Pubitemid 16041242)
23. E.R. King, C.S. Tung, and Y.T. Tsang The Anterior Gradient Homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer Am J Surg Pathol 35 2011 904 912
24. D. Yee, F.R. Morales, and T.C. Hamilton Expression of insulin-like growth factor I, its binding proteins, and its receptor in ovarian cancer Cancer Res 51 1991 5107 5112
25. D. Spentzos, S.A. Cannistra, and F. Grall IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer Endocr Relat Cancer 14 2007 781 790 (Pubitemid 350074066)
26. G.S. Huang, J. Brouwer-Visser, and M.J. Ramirez Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer Clin Cancer Res 16 2010 2999 3010
27. R.A. Sayer, J.M. Lancaster, and J. Pittman High insulin-like growth factor-2 (IGF-2) gene expression is an independent predictor of poor survival for patients with advanced stage serous epithelial ovarian cancer Gynecol Oncol 96 2005 355 361 (Pubitemid 40127134)
28. D.L. Reidy, E. Vakiani, and M.G. Fakih Randomized, phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab- or panitumumab-refractory metastatic colorectal cancer J Clin Oncol 28 2010 4240 4246
29. D.D. Karp, L.G. Paz-Ares, and S. Novello Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer J Clin Oncol 27 2009 2516 2522
30. R. Kurzrock, A. Patnaik, and J. Aisner A phase I study of weekly R1507, a human monoclonal antibody insulin-like growth factor-I receptor antagonist, in patients with advanced solid tumors Clin Cancer Res 16 2010 2458 2465
31. D.D. Karp, M.N. Pollak, and R.B. Cohen Safety, pharmacokinetics, and pharmacodynamics of the insulin-like growth factor type 1 receptor inhibitor figitumumab (CP-751,871) in combination with paclitaxel and carboplatin J Thorac Oncol 4 2009 1397 1403
32. L.K. Mullany, H.Y. Fan, and Z. Liu Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo Oncogene 2011 [epub ahead of print]