The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer

American Journal of Surgical Pathology

Volumn 35, Issue 6, 2011, Pages 904-912

  King, Erin R ^a   Tung, Celestine S ^a   Tsang, Yvonne T M ^a   Zu, Zhifei ^a   Lok, Gabriel T M ^a   Deavers, Michael T ^a   Malpica, Anais ^a   Wolf, Judith K ^a   Lu, Karen H ^a   Birrer, Michael J ^b   Mok, Samuel C ^a   Gershenson, David M ^a   Wong, Kwong Kwok ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

AGR3; BCMP11; biomarker; cilia; ovarian cancer

Indexed keywords

AGR3 PROTEIN, HUMAN; CARRIER PROTEIN; TUMOR MARKER; TUMOR PROTEIN;

ARTICLE; CELL COUNT; CELL DEDIFFERENTIATION; CELL SURVIVAL; CYSTADENOCARCINOMA; DISEASE COURSE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; OVARY TUMOR; PATHOLOGY; PROGNOSIS; UNITED STATES; UPREGULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CARRIER PROTEINS; CELL COUNT; CELL DEDIFFERENTIATION; CELL SURVIVAL; CYSTADENOCARCINOMA, SEROUS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; PROGNOSIS; TEXAS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 79957979681     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e318212ae22     Document Type: Article

References (30)

1. Adam PJ, Boyd R, Tyson KL, et al. Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J Biol Chem. 2003; 278:6482-6489. (Pubitemid 36800908)
2. Bonome T, Lee JY, Park DC, et al. Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary. Cancer Res. 2005;65:10602-10612. (Pubitemid 41743756)
3. Castleman VH, Romio L, Chodhari R, et al. Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities. Am J Hum Genet. 2009;84:197-209.
4. Fletcher GC, Patel S, Tyson K, et al. hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. Br J Cancer. 2003;88:579-585. (Pubitemid 36363368)
5. Fliegauf M, Olbrich H, Horvath J, et al. Mislocalization of DNAH5 and DNAH9 in respiratory cells from patients with primary ciliary dyskinesia. Am J Respir Crit Care Med. 2005;171:1343-1349. (Pubitemid 40800505)
6. Gilks CB, Vanderhyden BC, Zhu S, et al. Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling. Gynecol Oncol. 2005;96:684-694. (Pubitemid 40255487)
7. Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin. 2010;60:277-300.
8. Jensen-Smith HC, Luduena RF, Hallworth R. Requirement for the betaI and betaIV tubulin isotypes in mammalian cilia. Cell Motil Cytoskeleton. 2003;55:213-220. (Pubitemid 36791303)
9. Kaneko T, Murayama E, Kurio H, et al. Characterization of Spetex-1, a new component of satellite fibrils associated with outer dense fibers in the middle piece of rodent sperm flagella. Mol Reprod Dev. 2010;77:363-372.
10. Kubo A, Yuba-Kubo A, Tsukita S, et al. Sentan: a novel specific component of the apical structure of vertebrate motile cilia. Mol Biol Cell. 2008;19:5338-5346.
11. Larsson M, Norrander J, Graslund S, et al. The spatial and temporal expression of Tekt1, a mouse tektin C homologue, during spermatogenesis suggest that it is involved in the development of the sperm tail basal body and axoneme. Eur J Cell Biol. 2000;79:718-725.
12. Longacre TA, McKenney JK, Tazelaar HD, et al. Ovarian serous tumors of low malignant potential (borderline tumors): outcomebased study of 276 patients with long-term (or =5-year) followup. Am J Surg Pathol. 2005;29:707-723. (Pubitemid 40734421)
13. Malpica A, Deavers MT, Lu K, et al. Grading ovarian serous carcinoma using a two-tier system. Am J Surg Pathol. 2004;28:496-504. (Pubitemid 38436523)
14. Malpica A, Deavers MT, Tornos C, et al. Interobserver and intraobserver variability of a two-tier system for grading ovarian serous carcinoma. Am J Surg Pathol. 2007;31:1168-1174. (Pubitemid 47207118)
15. Marszalek JR, Ruiz-Lozano P, Roberts E, et al. Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II. Proc Natl Acad Sci USA. 1999;96:5043-5048. (Pubitemid 29214532)
16. Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 2004;6:1-6. (Pubitemid 38391943)
17. Sciallis AP, Aubry MC, Bell DA. Ciliated adenocarcinoma of the ovary with evidence of serous differentiation: report of a case. Int J Gynecol Pathol. 2009;28:447-452.
18. Shetty J, Klotz KL, Wolkowicz MJ, et al. Radial spoke protein 44 (human meichroacidin) is an axonemal alloantigen of sperm and cilia. Gene. 2007;396:93-107. (Pubitemid 46818782)
19. Shih Ie M, Kurman RJ. Molecular pathogenesis of ovarian borderline tumors: new insights and old challenges. Clin Cancer Res. 2005;11:7273-7279. (Pubitemid 41507684)
20. Shvartsman HS, Sun CC, Bodurka DC, et al. Comparison of the clinical behavior of newly diagnosed stages II-IV low-grade serous carcinoma of the ovary with that of serous ovarian tumors of low malignant potential that recur as low-grade serous carcinoma. Gynecol Oncol. 2007;105:625-629. (Pubitemid 46734181)
21. Silva EG, Gershenson DM, Malpica A, et al. The recurrence and the overall survival rates of ovarian serous borderline neoplasms with noninvasive implants is time dependent. Am J Surg Pathol. 2006;30:1367-1371. (Pubitemid 44655469)
22. Stenback F. Benign, borderline and malignant serous cystadenomas of the ovary: a transmission and scanning electron microscopical study. Pathol Res Pract. 1981;172:58-72. (Pubitemid 11026771)
23. Tung CS, Mok SC, Tsang YT, et al. PAX2 expression in low malignant potential ovarian tumors and low-grade ovarian serous carcinomas. Mod Pathol. 2009;22:1243-1250.
24. Vang R, Shih Ie M, Kurman RJ. Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Adv Anat Pathol. 2009;16:267-282.
25. Wong KK, Chang YM, Tsang YT, et al. Expression analysis of juvenile pilocytic astrocytomas by oligonucleotide microarray reveals two potential subgroups. Cancer Res. 2005;65:76-84. (Pubitemid 40070797)
26. Wong KK, Gershenson D. The continuum of serous tumors of low malignant potential and low-grade serous carcinomas of the ovary. Dis Markers. 2007;23:377-387. (Pubitemid 350171263)
27. Wong SY, Seol AD, So PL, et al. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nat Med. 2009;15:1055-1061.
28. Wong KK, Tsang YT, Deavers MT, et al. BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas. Am J Pathol. 2010;177:1611-1617.
29. Yuan K, Frolova N, Xie Y, et al. Primary cilia are decreased in breast cancer: analysis of a collection of human breast cancer cell lines and tissues. J Histochem Cytochem. 2010;58:857-870.
30. Zhou W, Li J, Wang X, et al. Stable knockdown of TPPP3 by RNA interference in Lewis lung carcinoma cell inhibits tumor growth and metastasis. Mol Cell Biochem. 2010;343:231-238.