Antibiotic therapy in neonatal and pediatric septic shock

Current Infectious Disease Reports

Volumn 13, Issue 5, 2011, Pages 433-441

  Aneja, Rajesh K ^a   Varughese Aneja, Ruby ^b   Vetterly, Carol G ^a   Carcillo, Joseph A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b WESTERN PENNSYLVANIA HOSPITAL   (United States)

Author keywords

Antibiotic therapy; Antibiotics; Multi drug resistant organisms; Neonatal sepsis; Pediatric sepsis; Septic shock

Indexed keywords

AMINOGLYCOSIDE; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; CARBAPENEM; CARBAPENEMASE; CEFOTAXIME; CEPHALOSPORIN; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; GENTAMICIN; LINEZOLID; MEROPENEM; NAFCILLIN; PENICILLIN G; PIPERACILLIN PLUS TAZOBACTAM; RIFAMPICIN; VANCOMYCIN;

ABDOMINAL INFECTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; BLOODSTREAM INFECTION; BONE MARROW SUPPRESSION; COAGULASE NEGATIVE STAPHYLOCOCCUS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG FATALITY; DRUG WITHDRAWAL; EARLY INTERVENTION; ENTEROBACTERIACEAE INFECTION; ENTEROCOCCAL INFECTION; HUMAN; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LACTIC ACIDOSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MITOCHONDRIAL TOXICITY; MULTIDRUG RESISTANCE; NEWBORN CARE; NEWBORN SEPSIS; NONHUMAN; ONSET AGE; PNEUMONIA; SEPSIS; SEPTIC SHOCK; STAPHYLOCOCCUS INFECTION; TREATMENT DURATION; TREATMENT PLANNING; VANCOMYCIN RESISTANT ENTEROCOCCUS;

EID: 80052583327     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-011-0197-5     Document Type: Article

References (53)

1. RS Watson JA Carcillo 2005 Scope and epidemiology of pediatric sepsis Pediatr Crit Care Med 6 3 Suppl S3 5 15857554 10.1097/01.PCC.0000161289.22464.C3 (Pubitemid 40724243)
2. RS Watson JA Carcillo WT Linde-Zwirble, et al. 2003 The epidemiology of severe sepsis in children in the United States Am J Respir Crit Care Med 167 5 695 701 12433670 10.1164/rccm.200207-682OC (Pubitemid 36801744)
3. M Hartman G Clermont D Angus R Watson 2008 Pediatric severe sepsis in the US: 1995 vs. 2005 Crit Care Med 36 A76
4. RS Watson JA Carcillo WT Linde-Zwirble, et al. 2003 The epidemiology of severe sepsis in children in the United States Am J Respir Crit Care Med 167 5 695 701 12433670 10.1164/rccm.200207-682OC (Pubitemid 36801744)
5. J Brierley JA Carcillo K Choong, et al. 2009 Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine Crit Care Med 37 2 666 88 19325359 10.1097/CCM.0b013e31819323c6 A must read for all pediatricians, as these are the guidelines for pediatric and neonatal septic shock.
6. A Kumar D Roberts KE Wood, et al. 2006 Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 34 6 1589 96 16625125 10.1097/01.CCM.0000217961.75225.E9 An important article that highlights the role of timely administration of antibiotics. (Pubitemid 43810035)
7. DF Gaieski ME Mikkelsen RA Band, et al. 2010 Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department Crit Care Med 38 4 1045 53 20048677 10.1097/CCM.0b013e3181cc4824
8. B Muller-Pebody AP Johnson PT Heath, et al. 2011 Empirical treatment of neonatal sepsis: are the current guidelines adequate? Arch Dis Child Fetal Neonatal Ed 96 1 F4 8 20584804 1:STN:280:DC%2BC3M%2FlvVeltg%3D%3D 10.1136/adc.2009.178483
9. Rao SC, Ahmed M, Hagan R. One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates. Cochrane Database Syst Rev. 2006;(1):CD005091.
10. Edwards M, Baker C. In: Long S, Pickering L, Prober C, editors. Bacterial infections in the neonate. Philadelphia: Churchill Livingstone; 2002.
11. S Vergnano E Menson N Kennea, et al. 2011 Neonatal infections in England: the NeonIN surveillance network Arch Dis Child Fetal Neonatal Ed 96 1 F9 F14 20876594 10.1136/adc.2009.178798 This is a prospective multi-center surveillance study that was conducted in 12 English neonatal units.
12. CS Bryan JF John Jr MS Pai TL Austin 1985 Gentamicin vs cefotaxime for therapy of neonatal sepsis. Relationship to drug resistance Am J Dis Child 139 11 1086 9 3904403 1:STN:280:DyaL28%2FkslOhtA%3D%3D (Pubitemid 16258031)
13. P de Man BA Verhoeven HA Verbrugh, et al. 2000 An antibiotic policy to prevent emergence of resistant bacilli Lancet 355 9208 973 8 10768436 10.1016/S0140-6736(00)90015-1 (Pubitemid 30148263)
14. N Modi V Damjanovic RW Cooke 1987 Outbreak of cephalosporin resistant Enterobacter cloacae infection in a neonatal intensive care unit Arch Dis Child 62 2 148 51 3827292 1:STN:280:DyaL2s7lsFChug%3D%3D 10.1136/adc.62.2.148 (Pubitemid 17004195)
15. RH Clark BT Bloom AR Spitzer DR Gerstmann 2006 Empiric use of ampicillin and cefotaxime, compared with ampicillin and gentamicin, for neonates at risk for sepsis is associated with an increased risk of neonatal death Pediatrics 117 1 67 74 16396862 10.1542/peds.2005-0179 (Pubitemid 46050521)
16. C Auriti A Maccallini G Di Liso, et al. 2003 Risk factors for nosocomial infections in a neonatal intensive-care unit J Hosp Infect 53 1 25 30 12495682 1:STN:280:DC%2BD38jjtl2muw%3D%3D 10.1053/jhin.2002.1341 (Pubitemid 38002085)
17. G Orsi G d'Ettorre A Panero, et al. 2009 Hospital-acquired infection surveillance in a neonatal intensive care unit Am J Infect Control 37 201 3 19059676 10.1016/j.ajic.2008.05.009
18. T Tan E Mason C Ou S Kaplan 1993 Use of intravenous rifampin in neonates with persistent staphylococcal bacteremia Antimicrob Agents Chemother 37 2401 6 8285624 1:STN:280:DyaK2c7htlKntg%3D%3D (Pubitemid 23324463)
19. J Wu C Chen P Tsao, et al. 2009 Neonatal sepsis: a 6-year analysis in a neonatal care unit in Taiwan Pediatr Neonatol 50 88 95 19579754 10.1016/S1875-9572(09)60042-5
20. M Khashu H Osiovich D Henry, et al. 2006 Persistent bacteremia and severe thrombocytopenia caused by coagulase-negative Staphylococcus in a neonatal intensive care unit Pediatrics 117 2 340 8 16452352 10.1542/peds.2005-0333 (Pubitemid 46074648)
21. GL Archer MJ Tenenbaum HB Haywood 3rd 1978 Rifampin therapy of Staphylococcus epidermidis. Use in infections from indwelling artificial devices JAMA. 240 8 751 3 671704 1:STN:280:DyaE1c3itFSisQ%3D%3D 10.1001/jama.240.8.751 (Pubitemid 9014952)
22. P Auger JP Laaban G Gagnon, et al. 1982 Rifampin therapy for Staphylococcus epidermidis endocarditis Can Med Assoc J 127 7 609 10 7127231 1:STN:280:DyaL3s%2FisVKisQ%3D%3D (Pubitemid 12000821)
23. B Chamovitz RE Bryant DN Gilbert AI Hartstein 1985 Prosthetic valve endocarditis caused by Staphylococcus epidermidis. Development of rifampin resistance during vancomycin and rifampin therapy JAMA. 253 19 2867 8 3989962 1:STN:280:DyaL2M7osFOrtQ%3D%3D 10.1001/jama.253.19.2867 (Pubitemid 15033086)
24. D Isaacs 2003 A ten year, multicentre study of coagulase negative staphylococcal infections in Australasian neonatal units Arch Dis Child Fetal Neonatal Ed 88 2 F89 F93 12598493 1:STN:280:DC%2BD3s%2Fos1Kjuw%3D%3D 10.1136/fn.88.2.F89
25. MG Karlowicz ES Buescher AE Surka 2000 Fulminant late-onset sepsis in a neonatal intensive care unit, 1988-1997, and the impact of avoiding empiric vancomycin therapy Pediatrics 106 6 1387 90 11099593 1:STN:280: DC%2BD3M%2FltVOrsw%3D%3D 10.1542/peds.106.6.1387
26. BJ Stoll N Hansen AA Fanaroff, et al. 2002 Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network Pediatrics 110 2 Pt 1 285 91 12165580 10.1542/peds.110.2.285 (Pubitemid 34833012)
27. A Gordon D Isaacs 2006 Late onset neonatal Gram-negative bacillary infection in Australia and New Zealand: 1992-2002 Pediatr Infect Dis J 25 1 25 9 16395098 10.1097/01.inf.0000195628.35980.2e
28. MC Kutko MP Calarco MB Flaherty, et al. 2003 Mortality rates in pediatric septic shock with and without multiple organ system failure Pediatr Crit Care Med 4 3 333 7 12831416 10.1097/01.PCC.0000074266.10576.9B
29. K Purcell J Fergie 2005 Epidemic of community-acquired methicillin-resistant Staphylococcus aureus infections: a 14-year study at Driscoll Children's Hospital Arch Pediatr Adolesc Med 159 10 980 5 16203945 10.1001/archpedi.159.10.980 (Pubitemid 41423339)
30. TJ Ochoa J Mohr A Wanger, et al. 2005 Community-associated methicillin-resistant Staphylococcus aureus in pediatric patients Emerg Infect Dis 11 6 966 8 15963299 (Pubitemid 40720865)
31. JM Smith GM Cook 2005 A decade of community MRSA in New Zealand Epidemiol Infect 133 5 899 904 16181511 1:STN:280:DC%2BD2MrhtVWisA%3D%3D 10.1017/S0950268805004024 (Pubitemid 41478976)
32. GJ Moran A Krishnadasan RJ Gorwitz, et al. 2006 Methicillin-resistant S. aureus infections among patients in the emergency department N Engl J Med 355 7 666 74 16914702 1:CAS:528:DC%2BD28Xot12mtLo%3D 10.1056/NEJMoa055356
33. S Boyle-Vavra RS Daum 2006 Community-acquired methicillin-resistant Staphylococcus aureus: the role of Panton-Valentine leukocidin Lab Invest 87 1 3 9 17146447 10.1038/labinvest.3700501
34. P Panton M Came F Valentine 1932 Staphylococcal toxin Lancet 1 506 8 10.1016/S0140-6736(01)24468-7
35. G Prevost B Cribier P Couppie, et al. 1995 Panton-Valentine leucocidin and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities Infect Immun 63 10 4121 9 7558328 1:CAS:528:DyaK2MXotlaht7w%3D
36. TE Zaoutis P Toltzis J Chu, et al. 2006 Clinical and molecular epidemiology of community-acquired methicillin-resistant Staphylococcus aureus infections among children with risk factors for health care-associated infection: 2001-2003 Pediatr Infect Dis J 25 4 343 8 16567987 10.1097/01.inf.0000207403.67197.cc
37. Y Gillet B Issartel P Vanhems, et al. 2002 Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients Lancet 359 9308 753 9 11888586 1:CAS:528:DC%2BD38XhvVWhtrw%3D 10.1016/S0140-6736(02)07877- 7 (Pubitemid 34215075)
38. PV Adem CP Montgomery AN Husain, et al. 2005 Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children N Engl J Med 353 12 1245 51 16177250 1:CAS:528:DC%2BD2MXhtVeltLbO 10.1056/NEJMoa044194 (Pubitemid 41345946)
39. K Mongkolrattanothai S Boyle MD Kahana RS Daum 2003 Severe Staphylococcus aureus infections caused by clonally related community-acquired methicillin-susceptible and methicillin-resistant isolates Clin Infect Dis 37 8 1050 8 14523769 10.1086/378277 (Pubitemid 37323659)
40. Y Gillet J Etienne G Lina F Vandenesch 2008 Association of necrotizing pneumonia with Panton-Valentine leukocidin-producing Staphylococcus aureus, regardless of methicillin resistance Clin Infect Dis 47 7 985 6 18778235 10.1086/591803
41. C Liu A Bayer SE Cosgrove, et al. 2011 Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children Clin Infect Dis 52 3 e18 55 21208910 10.1093/cid/ciq146
42. G Martinez-Aguilar WA Hammerman EO Mason Jr SL Kaplan 2003 Clindamycin treatment of invasive infections caused by community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus in children Pediatr Infect Dis J 22 7 593 8 12867833 (Pubitemid 36900204)
43. SL Kaplan B Afghani P Lopez, et al. 2003 Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children Pediatr Infect Dis J 22 9 Suppl S178 85 14520144
44. P Kopterides E Papadomichelakis A Armaganidis 2005 Linezolid use associated with lactic acidosis Scand J Infect Dis 37 2 153 4 15764207 1:CAS:528:DC%2BD2MXhtlOqsrY%3D 10.1080/00365540410026022 (Pubitemid 40298173)
45. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32(8):470-85.
46. LB Rice 2001 Emergence of vancomycin-resistant enterococci Emerg Infect Dis 7 2 183 7 11294702 1:CAS:528:DC%2BD3MXjtFOqu78%3D 10.3201/eid0702.010205 (Pubitemid 32374324)
47. HS Fraimow C Tsigrelis 2011 Antimicrobial resistance in the intensive care unit: mechanisms, epidemiology, and management of specific resistant pathogens Crit Care Clin 27 1 163 205 21144992 1:CAS:528:DC%2BC3cXhsFCqsLnP 10.1016/j.ccc.2010.11.002
48. J Sullivan JD Tobias 2006 Preliminary experience with the use of oral linezolid in infants for the completion of antibiotic therapy in the outpatient setting after admission to the pediatric intensive care unit Am J Ther 13 6 473 7 17122526 (Pubitemid 44813675)
49. DM Livermore M Warner S Mushtaq, et al. 2011 What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline Int J Antimicrob Agents 37 5 415 9 21429716 1:CAS:528: DC%2BC3MXksFemsrw%3D 10.1016/j.ijantimicag.2011.01.012
50. H Yigit AM Queenan GJ Anderson, et al. 2001 Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae Antimicrob Agents Chemother 45 4 1151 61 11257029 1:CAS:528:DC%2BD3MXit1Omsrc%3D 10.1128/AAC.45.4.1151-1161.2001 (Pubitemid 32230996)
51. HC Maltezou P Giakkoupi A Maragos, et al. 2009 Outbreak of infections due to KPC-2-producing Klebsiella pneumoniae in a hospital in Crete (Greece) J Infect 58 3 213 9 19246099 1:STN:280:DC%2BD1M7pt1Cjug%3D%3D 10.1016/j.jinf.2009. 01.010
52. S Bratu P Tolaney U Karumudi, et al. 2005 Carbapenemase-producing Klebsiella pneumoniae in Brooklyn, NY: molecular epidemiology and in vitro activity of polymyxin B and other agents J Antimicrob Chemother 56 1 128 32 15917285 1:CAS:528:DC%2BD2MXmsV2itbw%3D 10.1093/jac/dki175 (Pubitemid 41418346)
53. GD Overturf 2010 Carbapenemases: a brief review for pediatric infectious disease specialists Pediatr Infect Dis J 29 1 68 70 20035208