Synthesis and evaluation of compounds that induce readthrough of premature termination codons

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5842-5848

  Jung, Michael E ^a   Ku, Jin Mo ^a   Du, Liutao ^b   Hu, Hailiang ^b   Gatti, Richard A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Organic synthesis; Premature termination codons; Readthrough compounds; Thiazolidinones

Indexed keywords

1 PYRIMIDINYLMETHYLFURAN DERIVATIVE; FURAN DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR WEIGHT; REACTION ANALYSIS; RIBOSOME; STOP CODON; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ATAXIA TELANGIECTASIA; CELL CYCLE PROTEINS; CELL LINE; CODON, NONSENSE; CODON, TERMINATOR; DNA-BINDING PROTEINS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FURANS; HIGH-THROUGHPUT SCREENING ASSAYS; MOLECULAR STRUCTURE; MOLECULAR TARGETED THERAPY; MUTATION; OPEN READING FRAMES; PEPTIDE CHAIN TERMINATION, TRANSLATIONAL; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; RIBOSOMES; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEINS;

EID: 80052579665     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.107     Document Type: Article

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