Resistance to the translation initiation inhibitor silvestrol is mediated by ABCB1/P-glycoprotein overexpression in acute lymphoblastic leukemia cells

AAPS Journal

Volumn 13, Issue 3, 2011, Pages 357-364

  Gupta, Sneha V ^a   Sass, Ellen J ^b   Davis, Melanie E ^b   Edwards, Ryan B ^b   Lozanski, Gerard ^b   Heerema, Nyla A ^b   Lehman, Amy ^a   Zhang, Xiaoli ^a   Jarjoura, David ^a   Byrd, John C ^a,b   Pan, Li ^a   Chan, Kenneth K ^a   Kinghorn, A Douglas ^a   Phelps, Mitch A ^a   Grever, Michael R ^b   Lucas, David M ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

ABCB1; leukemia; multi drug resistance; P glycoprotein; silvestrol

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOSPORIN A; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; RHODAMINE 123; ROMIDEPSIN; SILVESTROL; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE;

ABCB1 GENE; ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG CYTOTOXICITY; DRUG DISPOSITION; DRUG EFFECT; DRUG MECHANISM; DRUG SENSITIZATION; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENE SILENCING; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; ONCOGENE; P GLYCOPROTEIN GENE; PHARMACOGENETICS; PROTEIN FUNCTION; PROTEIN TRANSPORT; TRANSLATION INITIATION;

CELL LINE, TUMOR; DATA INTERPRETATION, STATISTICAL; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; HUMANS; P-GLYCOPROTEIN; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN SYNTHESIS INHIBITORS; RNA, SMALL INTERFERING; TRITERPENES; UP-REGULATION;

EID: 80052575249     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9276-7     Document Type: Article

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