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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 6007-6012

Dual pro-drugs of 2′-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus

(13) McGuigan, Christopher a Madela, Karolina a Aljarah, Mohamed a Gilles, Arnaud a Battina, Srinivas K c Ramamurty, Changalvala V S c Srinivas Rao, C c Vernachio, John b Hutchins, Jeff b Hall, Andrea b Kolykhalov, Alexander b Henson, Geoffrey b Chamberlain, Stanley b

a CARDIFF UNIVERSITY (United Kingdom)

b Inhibitex Inc (United States)

c CiVentiChem (United States)

Author keywords

HCV; NS5B; Nucleoside; Nucleotide; Phosphoramidate; Polymerase; ProTide

Indexed keywords

2' METHYLGUANOSINE MONOPHOSPHATE; ANTIVIRUS AGENT; CARBOXYPEPTIDASE C; INX 189; NUCLEOSIDE; NUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ARTICLE; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; HEPATITIS C; HEPATITIS C VIRUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER CELL; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; VIRUS HEPATITIS; VIRUS INHIBITION;

5'-GUANYLIC ACID; AMIDES; AMP DEAMINASE; ANTIVIRAL AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HEPACIVIRUS; HEPATITIS C; HUMANS; HYDROLYSIS; INHIBITORY CONCENTRATION 50; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; PHOSPHORIC ACIDS; PHOSPHORYLATION; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 80052567516 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.013 Document Type: Article

Times cited : (16)

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