A single synthetic small molecule that generates force against a load

Nature Nanotechnology

Volumn 6, Issue 9, 2011, Pages 553-557

  Lussis, Perrine ^a   Svaldo Lanero, Tiziana ^a   Bertocco, Andrea ^b   Fustin, Charles André ^c   Leigh, David A ^b   Duwez, Anne Sophie ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC FORCE MICROSCOPY; AXLES; BROWNIAN MOVEMENT; FREE ENERGY; HYDROGEN BONDS; MOLECULAR ELECTRONICS; MOLECULAR SPECTROSCOPY; MOLECULES;

ARTIFICIAL MOLECULAR MACHINES; FLUCTUATION THEOREMS; MOLECULAR COMPONENTS; MOLECULAR MACHINES; MUSCLE CONTRACTIONS; RANDOM THERMAL MOTION; SINGLE MOLECULE LEVEL; SYNTHETIC MOLECULES;

SYNTHESIS (CHEMICAL);

NANOPARTICLE; ROTAXANE;

ARTICLE; ATOMIC FORCE MICROSCOPY; CHEMICAL STRUCTURE; FORCE; HYDROGEN BOND; MEASUREMENT; MOLECULAR DYNAMICS; NANOTECHNOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THERMODYNAMICS;

EID: 80052564356     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2011.132     Document Type: Article

References (33)

1. Schliwa, M. (ed.) Molecular Motors (Wiley-VCH, 2003).
2. Kinbara, K. & Aida, T. Toward intelligent molecular machines: Directed motions of biological and artificial molecules and assemblies. Chem. Rev. 105, 1377-1400 (2005).
3. Kay, E. R., Leigh, D. A. & Zerbetto, F. Synthetic molecular motors and mechanical machines. Angew. Chem. Int. Ed. 46, 72-191 (2007).
4. Browne, W. & Feringa, B. L. Making molecular machines work. Nature Nanotech. 1, 25-35 (2006).
5. Berná, J. et al. Macroscopic transport by synthetic molecular machines. Nature Mater. 4, 704-710 (2005).
6. Liu, Y. et al. Linear artificial molecular muscles. J. Am. Chem. Soc. 127, 9745-9759 (2005).
7. Eelkema, R. et al. Molecular machines: Nanomotor rotates microscale objects. Nature 440, 163 (2006).
8. Kay, E. R. & Leigh, D. A. Hydrogen bond-assembled synthetic molecular motors and machines. Top. Curr. Chem. 262, 133-177 (2005).
9. Balzani, V. et al. Autonomous artificial nanomotor powered by sunlight. Proc. Natl Acad. Sci. USA 103, 1178-1183 (2006).
10. Serreli, V., Lee, C-F., Kay, E. R. & Leigh, D. A. A molecular information ratchet. Nature 445, 523-527 (2007).
11. Panman, M. R. et al. Operation mechanism of a molecular machine revealed using time-resolved vibrational spectroscopy. Science 328, 1255-1258 (2010).
12. Rijs, A. M. et al. Controlled hydrogen-bond breaking in a rotaxane by discrete solvation. Angew. Chem. Int. Ed. 49, 3896-3900 (2010).
13. Bustamante, C., Chemla, Y. R., Forde, N. R. & Izhaky, D. Mechanical processes in biochemistry. Annu. Rev. Biochem. 73, 705-748 (2004).
14. Special issue. Annu. Rev. Biochem. 77, 45-228 (2008).
15. Evans, E. Probing the relation between force-lifetime-and chemistry in single molecular bonds. Annu. Rev. Biophys. Biomol. Struct. 30, 105-128 (2001).
16. Liang, J. & Fernańdez, J. M. Mechanochemistry: One bond at a time. ACS Nano 3, 1628-1645 (2009).
17. Janke, M. et al. Mechanically interlocked calix[4]arene dimers display reversible bond breakage under force. Nature Nanotech. 4, 225-229 (2009).
18. Puchner, E. M. & Gaub, H. E. Force and function: Probing proteins with AFMbased force spectroscopy. Curr. Opin. Struct. Biol. 19, 605-614 (2009).
19. Hugel, T. et al. Single-molecule optomechanical cycle. Science 296, 1103-1106 (2002).
20. Lee, G. et al. Nanospring behaviour of ankyrin repeats. Nature 440, 246-249 (2006).
21. Brough, B. et al. Evaluation of synthetic linear motor-molecule actuation energetics. Proc. Natl Acad. Sci. USA 103, 8583-8588 (2006).
22. Altieri, A. et al. Remarkable positional discrimination in bistable light- and heat-switchable hydrogen-bonded molecular shuttles. Angew. Chem. Int. Ed. 42, 2296-2300 (2003).
23. Rostovtsev, V. V., Green, L. G., Fokin, V. V. & Sharpless, K. B. A stepwise Huisgen cycloaddition process: Copper(I)-catalysed regioselective ligation of azides and terminal alkynes. Angew. Chem. Int. Ed. 41, 2596-2599 (2002).
24. Grandbois, M., Beyer, M., Rief, M., Clausen-Schaumann, H. & Gaub, H. E. How strong is a covalent bond? Science 283, 1727-1730 (1999).
25. Duwez, A-S. et al. Mechanochemistry: Targeted delivery of single molecules. Nature Nanotech. 1, 122-125 (2006).
26. Hunter, C. A. Quantifying intermolecular interactions: Guidelines for the molecular recognition toolbox. Angew. Chem. Int. Ed. 43, 5310-5324 (2004).
27. Flory, P. J. Statistical Mechanics of Chain Molecules (Hanser, 1989).
28. Mark, J. E. & Flory, P. J. The configuration of the polyoxyethylene chain. J. Am. Chem. Soc. 87, 1415-1423 (1965).
29. Crooks, G. E. Entropy production fluctuation theorem and the nonequilibrium work relation for free-energy differences. Phys. Rev. E 60, 2721-2726 (1999).
30. Liphardt, J., Dumont, S., Smith, S. B., Tinoco Jr, I. & Bustamante, C. Equilibrium information from nonequilibrium measurements in an experimental test of Jarzynski's equality. Science 296, 1832-1835 (2002).
31. Collin, C. et al. Verification of the Crooks fluctuation theorem and recovery of RNA folding free energies. Nature 437, 231-234 (2005).
32. Leigh, D. A.,Wong, J. K. Y., Dehez, F. & Zerbetto, F. Unidirectional rotation in a mechanically interlocked molecular rotor. Nature 424, 174-179 (2003).
33. Jarzynski, C. Nonequilibrium equality for free energy differences. Phys. Rev. Lett. 78, 2690-2693 (1997).