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Volumn 10, Issue 1, 2011, Pages

Fermented wheat germ extract - Nutritional supplement or anticancer drug?

Author keywords

clinical activity; Fermented wheat germ extract; in vitro effects; in vivo effects

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; CYTOKINE; DACARBAZINE; DOXORUBICIN; FERMENTED WHEAT GERM EXTRACT; FLUOROURACIL; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; NAVELBINE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AVEMAR;

EID: 80052563054     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-10-89     Document Type: Review
Times cited : (57)

References (40)
  • 1
    • 67649982995 scopus 로고    scopus 로고
    • Mechanisms of cancer cachexia
    • 10.1152/physrev.00016.2008 19342610
    • Mechanisms of cancer cachexia. Tisdale MJ, Physiol Rev 2009 89 2 381 410 10.1152/physrev.00016.2008 19342610
    • (2009) Physiol Rev , vol.89 , Issue.2 , pp. 381-410
    • Tisdale, M.J.1
  • 3
    • 77952473456 scopus 로고    scopus 로고
    • Avemar (wheat germ extract) in cancer prevention and treatment
    • 10.1080/01635580903285114 20155632
    • Avemar (wheat germ extract) in cancer prevention and treatment. Telekes A, Hegedus M, Chae CH, Vekey K, Nutr Cancer 2009 61 6 891 899 10.1080/01635580903285114 20155632
    • (2009) Nutr Cancer , vol.61 , Issue.6 , pp. 891-899
    • Telekes, A.1    Hegedus, M.2    Chae, C.H.3    Vekey, K.4
  • 5
    • 34250309936 scopus 로고    scopus 로고
    • Safety studies regarding a standardized extract of fermented wheat germ
    • DOI 10.1080/10915810701369709, PII 779514289
    • Safety studies regarding a standardized extract of fermented wheat germ. Heimbach JT, Sebestyen G, Semjen G, Kennepohl E, Int J Toxicol 2007 26 3 253 259 10.1080/10915810701369709 17564907 (Pubitemid 46918918)
    • (2007) International Journal of Toxicology , vol.26 , Issue.3 , pp. 253-259
    • Heimbach, J.T.1    Sebestyen, G.2    Semjen, G.3    Kennepohl, E.4
  • 6
    • 79955116967 scopus 로고    scopus 로고
    • Promising cytotoxic activity profile of fermented wheat germ extract (Avemar(R)) in human cancer cell lines
    • 10.1186/1756-9966-30-42 21496306
    • Promising cytotoxic activity profile of fermented wheat germ extract (Avemar(R)) in human cancer cell lines. Mueller T, Jordan K, Voigt W, J Exp Clin Cancer Res 2011 30 42 10.1186/1756-9966-30-42 21496306
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 42
    • Mueller, T.1    Jordan, K.2    Voigt, W.3
  • 7
    • 3142689713 scopus 로고    scopus 로고
    • Effect of simultaneous administration of Avemar® and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival of tumor-bearing mice
    • DOI 10.1089/1084978041425016
    • Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival tumor-bearing mice. Szende B, Marcsek Z, Kocsis Z, Tompa A, Cancer Biother Radiopharm 2004 19 3 343 349 10.1089/1084978041425016 15285880 (Pubitemid 38924498)
    • (2004) Cancer Biotherapy and Radiopharmaceuticals , vol.19 , Issue.3 , pp. 343-349
    • Szende, B.1    Marcsek, Z.2    Kocsis, Z.3    Tompa, A.4
  • 8
    • 0037085584 scopus 로고    scopus 로고
    • Metabolic profiling of cell growth and death in cancer: Applications in drug discovery
    • DOI 10.1016/S1359-6446(02)02179-7, PII S1359644602021797
    • Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Boros LG, Cascante M, Lee WN, Drug Discov Today 2002 7 6 364 372 10.1016/S1359-6446(02)02179-7 11893545 (Pubitemid 34226656)
    • (2002) Drug Discovery Today , vol.7 , Issue.6 , pp. 364-372
    • Boros, L.G.1    Cascante, M.2    Paul Lee, W.-N.3
  • 9
    • 2242485601 scopus 로고    scopus 로고
    • Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells
    • DOI 10.1074/jbc.M206150200
    • Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. Comin-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M, J Biol Chem 2002 277 48 46408 46414 10.1074/jbc.M206150200 12351627 (Pubitemid 35417635)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.48 , pp. 46408-46414
    • Comin-Anduix, B.1    Boros, L.G.2    Marin, S.3    Boren, J.4    Callol-Massot, C.5    Centelles, J.J.6    Torres, J.L.7    Agell, N.8    Bassilian, S.9    Cascante, M.10
  • 10
    • 0034915207 scopus 로고    scopus 로고
    • Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells
    • DOI 10.1097/00006676-200108000-00004
    • Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Boros LG, Lapis K, Szende B, Tomoskozi-Farkas R, Balogh A, Boren J, Marin S, Cascante M, Hidvegi M, Pancreas 2001 23 2 141 147 10.1097/00006676-200108000-00004 11484916 (Pubitemid 32692123)
    • (2001) Pancreas , vol.23 , Issue.2 , pp. 141-147
    • Boros, L.G.1    Lapis, K.2    Szende, B.3    Tomoskozi-Farkas, R.4    Balogh, A.5    Boren, J.6    Marin, S.7    Cascante, M.8    Hidvegi, M.9
  • 11
    • 0034282791 scopus 로고    scopus 로고
    • Preventive potential of wheat bran fractions against experimental colon carcinogenesis: Implications for human colon cancer prevention
    • 10987288
    • Preventive potential of wheat bran fractions against experimental colon carcinogenesis: implications for human colon cancer prevention. Reddy BS, Hirose Y, Cohen LA, Simi B, Cooma I, Rao CV, Cancer Res 2000 60 17 4792 4797 10987288
    • (2000) Cancer Res , vol.60 , Issue.17 , pp. 4792-4797
    • Reddy, B.S.1    Hirose, Y.2    Cohen, L.A.3    Simi, B.4    Cooma, I.5    Rao, C.V.6
  • 12
    • 0019459845 scopus 로고
    • Role of ribonucleotide reductase in expression of the neoplastic program
    • DOI 10.1016/0024-3205(81)90746-3
    • Role of ribonucleotide reductase in expression in the neoplastic program. Takeda E, Weber G, Life Sci 1981 28 9 1007 1014 10.1016/0024-3205(81)90746-3 7012518 (Pubitemid 11110086)
    • (1981) Life Sciences , vol.28 , Issue.9 , pp. 1007-1014
    • Takeda, E.1    Weber, G.2
  • 14
    • 33745823841 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibitors and future drug design
    • DOI 10.2174/156800906777723949
    • Ribonucleotide reductase inhibitors and future drug design. Shao J, Zhou B, Chu B, Yen Y, Curr Cancer Drug Targets 2006 6 5 409 431 10.2174/ 156800906777723949 16918309 (Pubitemid 44033390)
    • (2006) Current Cancer Drug Targets , vol.6 , Issue.5 , pp. 409-431
    • Shao, J.1    Zhou, B.2    Chu, B.3    Yen, Y.4
  • 15
    • 25444529186 scopus 로고    scopus 로고
    • Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases
    • DOI 10.1196/annals.1361.097
    • Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases. Boros LG, Nichelatti M, Shoenfeld Y, Ann N Y Acad Sci 2005 1051 529 542 10.1196/annals.1361.097 16126993 (Pubitemid 41362780)
    • (2005) Annals of the New York Academy of Sciences , vol.1051 , pp. 529-542
    • Boros, L.G.1    Nichelatti, M.2    Shoenfeld, Y.3
  • 17
    • 64849114221 scopus 로고    scopus 로고
    • Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis
    • 19212640
    • Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis. Saiko P, Ozsvar-Kozma M, Graser G, Lackner A, Grusch M, Madlener S, Krupitza G, Jaeger W, Hidvegi M, Agarwal RP, et al. Oncol Rep 2009 21 3 787 791 19212640
    • (2009) Oncol Rep , vol.21 , Issue.3 , pp. 787-791
    • Saiko, P.1    Ozsvar-Kozma, M.2    Graser, G.3    Lackner, A.4    Grusch, M.5    Madlener, S.6    Krupitza, G.7    Jaeger, W.8    Hidvegi, M.9    Agarwal, R.P.10
  • 20
    • 0031810683 scopus 로고    scopus 로고
    • Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals
    • Effect of Avemar and Avemar + vitamin C on tumor growth and metastasis in experimental animals. Hidvegi M, Raso E, Tomoskozi-Farkas R, Paku S, Lapis K, Szende B, Anticancer Res 1998 18 4A 2353 2358 9703878 (Pubitemid 28386519)
    • (1998) Anticancer Research , vol.18 , Issue.4 A , pp. 2353-2358
    • Hidvegi, M.1    Raso, E.2    Tomoskozi-Farkas, R.3    Paku, S.4    Lapis, K.5    Szende, B.6
  • 22
    • 51349168942 scopus 로고    scopus 로고
    • Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments
    • 18089890
    • Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments. Tejeda M, Gaal D, Szucs I, Telekes A, J Clin Oncol 2007 25 #21132 18089890
    • (2007) J Clin Oncol , vol.25 , pp. 21132
    • Tejeda, M.1    Gaal, D.2    Szucs, I.3    Telekes, A.4
  • 23
    • 14044265107 scopus 로고    scopus 로고
    • The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment
    • DOI 10.1089/cbr.2004.19.746
    • The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment. Marcsek Z, Kocsis Z, Jakab M, Szende B, Tompa A, Cancer Biother Radiopharm 2004 19 6 746 753 10.1089/cbr.2004.19.746 15665622 (Pubitemid 40279583)
    • (2004) Cancer Biotherapy and Radiopharmaceuticals , vol.19 , Issue.6 , pp. 746-753
    • Marcsek, Z.1    Kocsis, Z.2    Jakab, M.3    Szende, B.4    Tompa, A.5
  • 24
    • 0034789014 scopus 로고    scopus 로고
    • Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats
    • Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats. Zalatnai A, Lapis K, Szende B, Raso E, Telekes A, Resetar A, Hidvegi M, Carcinogenesis 2001 22 10 1649 1652 10.1093/carcin/22.10.1649 11577004 (Pubitemid 32952142)
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1649-1652
    • Zalatnai, A.1    Lapis, K.2    Szende, B.3    Raso, E.4    Telekas, A.5    Resetar, A.6    Hidvegi, M.7
  • 25
    • 51349168942 scopus 로고    scopus 로고
    • Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments
    • 18089890
    • Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments. Tejeda M, Gaal D, Szucs I, Telekes A, J Clin Oncol 2007 25 20 #21132 18089890
    • (2007) J Clin Oncol , vol.25 , Issue.20 , pp. 21132
    • Tejeda, M.1    Gaal, D.2    Szucs, I.3    Telekes, A.4
  • 27
    • 0030044629 scopus 로고    scopus 로고
    • Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: The role of angiogenic factors
    • Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Griffioen AW, Damen CA, Martinotti S, Blijham GH, Groenewegen G, Cancer Res 1996 56 5 1111 1117 8640769 (Pubitemid 26065408)
    • (1996) Cancer Research , vol.56 , Issue.5 , pp. 1111-1117
    • Griffioen, A.W.1    Damen, C.A.2    Martinotti, S.3    Blijham, G.H.4    Groenewegen, G.5
  • 28
    • 2542508595 scopus 로고    scopus 로고
    • Effect of MSC on the immune response of mice
    • DOI 10.1016/S0162-3109(99)00002-8, PII S0162310999000028
    • Effect of MSC on the immune response of mice. Hidvegi M, Raso E, Tomoskozi Farkas R, Lapis K, Szende B, Immunopharmacology 1999 41 3 183 186 10.1016/S0162-3109(99)00002-8 10428646 (Pubitemid 29243820)
    • (1999) Immunopharmacology , vol.41 , Issue.3 , pp. 183-186
    • Hidvegi, M.1    Raso, E.2    Farkas, R.T.3    Lapis, K.4    Szende, B.5
  • 29
    • 51349098875 scopus 로고    scopus 로고
    • Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: A randomized, pilot, phase II clinical study with a 7-year follow-up
    • 10.1089/cbr.2008.0486 18771352
    • Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up. Demidov LV, Manziuk LV, Kharkevitch GY, Pirogova NA, Artamonova EV, Cancer Biother Radiopharm 2008 23 4 477 482 10.1089/cbr.2008.0486 18771352
    • (2008) Cancer Biother Radiopharm , vol.23 , Issue.4 , pp. 477-482
    • Demidov, L.V.1    Manziuk, L.V.2    Kharkevitch, G.Y.3    Pirogova, N.A.4    Artamonova, E.V.5
  • 30
    • 25444452499 scopus 로고    scopus 로고
    • Tumours of the sigma and rectum: The completion of postoperative chemotherapy with Avemar
    • Tumours of the sigma and rectum: the completion of postoperative chemotherapy with Avemar. Koti C, Lengyel L, Magy Seb 2004 57 168
    • (2004) Magy Seb , vol.57 , pp. 168
    • Koti, C.1    Lengyel, L.2
  • 31
    • 0034004550 scopus 로고    scopus 로고
    • First clinical data of a natural immunomodulator in colorectal cancer
    • First clinical data of a natural immunomodulator in colorectal cancer. Jakab F, Mayer A, Hoffmann A, Hidvegi M, Hepatogastroenterology 2000 47 32 393 395 10791198 (Pubitemid 30216299)
    • (2000) Hepato-Gastroenterology , vol.47 , Issue.32 , pp. 393-395
    • Jakab, F.1    Mayer, A.2    Hoffmann, A.3    Hidvegi, M.4
  • 33
    • 85013605171 scopus 로고    scopus 로고
    • A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar)
    • 10.1007/s12349-008-0008-4
    • A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar). Sukkar SG, Cella F, Rovera GM, Nichelatti M, Ragni G, Chiavenna G, Giannoni A, Ronzani G, Ferrari CA, J Nutr Metab 2008 1 37 42 10.1007/s12349-008-0008-4
    • (2008) J Nutr Metab , vol.1 , pp. 37-42
    • Sukkar, S.G.1    Cella, F.2    Rovera, G.M.3    Nichelatti, M.4    Ragni, G.5    Chiavenna, G.6    Giannoni, A.7    Ronzani, G.8    Ferrari, C.A.9
  • 34
    • 25444508529 scopus 로고    scopus 로고
    • The effect of Avemar treatment on the regeneration of leukocytes, thrombocytes and reticulocytes in sublethally irradiated or cyclophosphamide treated mice
    • The effect of Avemar treatment on the regeneration of leukocytes, thrombocytes and reticulocytes in sublethally irradiated or cyclophosphamide treated mice. Gidali J, Hidvegi M, Feher I, Lapis K, First Congress of the Hungarian Society of Clinical Oncology, Budapest 2000
    • (2000) First Congress of the Hungarian Society of Clinical Oncology, Budapest
    • Gidali, J.1    Hidvegi, M.2    Feher, I.3    Lapis, K.4
  • 36
    • 0033056271 scopus 로고    scopus 로고
    • Importance of glucose-6-phosphate dehydrogenase activity in cell death
    • 10329961
    • Importance of glucose-6-phosphate dehydrogenase activity in cell death. Tian WN, Braunstein LD, Apse K, Pang J, Rose M, Tian X, Stanton RC, Am J Physiol 1999 276 5 Pt 1 1121 1131 10329961
    • (1999) Am J Physiol , vol.276 , Issue.5 PART 1 , pp. 31121-1131
    • Tian, W.N.1    Braunstein, L.D.2    Apse, K.3    Pang, J.4    Rose, M.5    Tian, X.6    Stanton, R.C.7
  • 37
    • 0034045004 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation
    • Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation. Tuttle S, Stamato T, Perez ML, Biaglow J, Radiat Res 2000 153 6 781 787 10.1667/0033-7587(2000)153[0781:GPDATO]2.0.CO;2 10825753 (Pubitemid 30349553)
    • (2000) Radiation Research , vol.153 , Issue.6 , pp. 781-787
    • Tuttle, S.1    Stamato, T.2    Perez, M.L.3    Biaglow, J.4
  • 40
    • 0035851102 scopus 로고    scopus 로고
    • Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells
    • 11489902
    • Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. Boren J, Cascante M, Marin S, Comin-Anduix B, Centelles JJ, Lim S, Bassilian S, Ahmed S, Lee WN, Boros LG, J Biol Chem 2001 276 41 37747 37753 11489902
    • (2001) J Biol Chem , vol.276 , Issue.41 , pp. 37747-37753
    • Boren, J.1    Cascante, M.2    Marin, S.3    Comin-Anduix, B.4    Centelles, J.J.5    Lim, S.6    Bassilian, S.7    Ahmed, S.8    Lee, W.N.9    Boros, L.G.10


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