Potential dopamine-1 receptor stimulation in hypertension management

Current Hypertension Reports

Volumn 13, Issue 4, 2011, Pages 294-302

  Asghar, Mohammad ^a   Tayebati, Seyed K ^a,b   Lokhandwala, Mustafa F ^a   Hussain, Tahir ^a  

^a UNIVERSITY OF HOUSTON   (United States)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Blood pressure; Dopamine receptors; G protein coupled receptors; Hypertension; Natriuresis Diuresis; Sodium transporters

Indexed keywords

DOPAMINE 1 RECEPTOR; DOPAMINE 5 RECEPTOR; ECOPIPAM; FENOLDOPAM; G PROTEIN COUPLED RECEPTOR KINASE; NIFEDIPINE; NITROPRUSSIDE SODIUM;

ANTIHYPERTENSIVE THERAPY; ARTICLE; BLOOD PRESSURE REGULATION; DIALYSIS; DOPAMINE D1 RECEPTOR GENE; DRUG MECHANISM; ENZYME ACTIVITY; G PROTEIN COUPLED RECEPTOR KINASE GENE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HUMAN; HYPERTENSION; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR GENE;

BLOOD PRESSURE; G-PROTEIN-COUPLED RECEPTOR KINASES; HOMEOSTASIS; HUMANS; HYPERTENSION; OXIDATIVE STRESS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, DOPAMINE D1;

EID: 80052555703     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-011-0211-1     Document Type: Article

References (111)

1. Mancia G, De Backer G, Dominiczak A, et al. Guidelines for themanagement of arterial hypertension: the task force for themanagement of arterial hypertension of the european siety ofhypertension (ESH) and of the european society of cardiology(ESC). J Hypertens. 2007;25:1105-87. (Pubitemid 46924065)
2. Ruggenenti P, Fassi A, IlievaAP, et al. Preventingmicroalbuminuria in diabetes. N Engl J Med. 2004;351:1941-51.
3. Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects ofenalapril and losartan in type 1 diabetes. N Engl J Med.2009;361:40-51.
4. Hemmelgarn HR, Manns BJ, Lloyd A, et al. Relation betweenkidney function, proteinuria,and adverse outcomes. JAMA.2010;303:423-9.
5. Pugsley MK. The angiotensin-II (AT-II) receptor blocker olmesartanreduces renal damagin animal models of hypertension and diabetes.Proc West Pharmacol Soc. 2005;48:35-8. (Pubitemid 43053796)
6. Gerstein HC, Mann JFE, Yi Q, et al. Albuminuria and risk ofcardiovascular events, deah, and heart failure in diabetic andnondiabetic individuals. JAMA. 2001;286:421-6. (Pubitemid 32681484)
7. Grassi G, Quarti-Trevano F, Dell'Oro R, Mancia G. The "J curve"problem revisited: oldand new findings. Curr Hypertens Rep.2010;12:290-5.
8. Messerli FH, Mancia G, Conti CR, et al. Dogma disputed: canaggressively lowering bloo in hypertensive patients withcoronary artery disease be dangerous? Ann Intern Med.2006;144:884-93. (Pubitemid 46768128)
9. O'Connell DP, Botkin SJ, Ramos SI, et al. Localization ofdopamine D1A receptor protein in rat kidneys. Am J Physiol.1995;268:F1185-97.
10. Ozono R, O'Connell DP, Wang ZQ, et al. Localization of thedopamine D1 receptor protein in the human heart and kidney.Hypertension. 1997;30:725-9. (Pubitemid 27444263)
11. Yamaguchi I, Jose PA, Mouradian MM, et al. Expression ofdopamine D1A receptor gene in proximal tubule of rat kidneys.Am J Physiol. 1993;264:F280-5. (Pubitemid 23068486)
12. Ricci A, Amenta F, Bronzetti E, et al. Age-related changes ofdopamine receptor protein immunoreactivity in the rat mesentericvascular tree. Mech Ageing Dev. 2002;123:537-46. (Pubitemid 34127683)
13. Amenta F, Barili P, Bronzetti E, et al. Localization of dopaminereceptor subtypes in systemic arteries. Clin Exp Hypertens.2000;22:277-88. (Pubitemid 30305951)
14. Kim MO, Koh PO, Kim JH, et al. Localization of dopamine D1and D2 receptor mRNAs in the rat systemic and pulmonaryvasculatures. Mol Cell. 1999;9:417-21. (Pubitemid 129602561)
15. Zheng S, Yu P, Zeng C, et al. Gá12- and Gá13-protein subunitlinkage of D5 dopamine receptors in the nephron. Hypertension.2003;41: 604-10. (Pubitemid 36314639)
16. Amenta F. Light microscope autoradiography of peripheraldopamine receptor subtypes. Clin Exp Hypertens.1997;19:27-41. (Pubitemid 27084523)
17. Ricci A, Chiandussi L, Schena M, et al. Dopamine D5 receptorexpression is unchanged in peripheral blood lymphocytes inessential hypertension. Clin Exp Hypertens. 1995;17:1157-72.
18. Ortiz PA, Garvin JL. Intrarenal transport and vasoactivesubstances in hypertension. Hypertension. 2001;38:621-4.
19. Aviv A, Hollenberg NK, Weder A. Urinary potassium excretionand sodium sensitivity in blacks. Hypertension. 2004;43:707-13. (Pubitemid 38405572)
20. Redon J, Lurbe E. Nocturnal blood pressure versus nondippingpattern: what do they mean? Hypertension. 2008;511:41-2. (Pubitemid 350307100)
21. Kuchel OG, Kuchel GA. Peripheral dopamine in pathophysiologyof hypertension. Interaction with aging and lifestyle.Hypertension. 1991;18:709-21.
22. Damasceno A, Santos A, Serrao P, et al. Deficiency of renaldopaminergic-dependent natriuretic response to acute sodiumload in black salt-sensitive subjects in contrast to salt-resistantsubjects. J Hypertens. 1999;17:1995-2001. (Pubitemid 30345343)
23. Clark BA, Rosa RM, Epstein FH, et al. Altered dopaminergicresponses in hypertension. Hypertension. 1992;19:589-94.
24. Romero-Vecchione E, Vasquez J, Lema G, et al. Low urinarydopamine excretion associated to low sodium excretion innormotensive Piaroa Amazonian ethnia compared to urbansubjects. Invest Clin. 1995;36:61-71.
25. Gill Jr JR. Grossman E, Goldstein DS: High urinary dopa andlow urinary dopamine-to-dopa ratio in salt-sensitive hypertension.Hypertension. 1991;18:614-21.
26. Saito I, Takeshita E, Saruta T, et al. Urinary dopamine excretionin normotensive subjects with or without family history ofhypertension. J Hypertens. 1986;4:57-60. (Pubitemid 16129684)
27. Saito I, Itsuji S, Takeshita E, et al. Increased urinary dopamine excretion in young patients with essential hypertension. Clin ExpHypertens. 1994;16:29-39. (Pubitemid 24070397)
28. Grossman E, Hoffman A, Tamrat M, et al. Endogenous dopa and dopamine responses to dietary salt loading in salt-sensitive rats. JHypertens. 1991;9:259-63.
29. Stier Jr CT. Itskovitz HD, Chen YH: Urinary dopamine andsodium excretion in spontaneously hypertensive rats. Clin ExpHypertens. 1993;15:105-23. (Pubitemid 23057331)
30. Yoshimura M, Kambara S, Okabayashi H, et al. Effect ofdecreased dopamine synthesis on the development of hypertensioninduced by salt loading in spontaneously hypertensive rats.Clin Exp Hypertens. 1987;A9:1141-57.
31. Jose PA, Eisner GM, Drago J, et al. Dopamine receptor signalingdefects in spontaneous hypertension. Am J Hypertens.1996;9:400-5. (Pubitemid 26128249)
32. Lifton RP, Wilson FH, Choate KA, Geller DS. Salt and blood pressure: new insight from human genetic studies. Cold Spring Harbor Symp Quant Biol. 2002;67:445-50. (Pubitemid 36775540)
33. Siragy HM, Felder RA, Howell NL, et al. Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule. Am J Physiol. 1989;257:F469-77.
34. Jose PA, Asico LD, Eisner GM, et al. Effects of costimulation ofdopamine D1- and D2-like receptors on renal function. Am JPhysiol. 1998;275:R986-9.
35. Hansell P, Fasching A. The effect of dopamine receptor blockadeon natriuresis is dependent on the degree of hypervolemia.Kidney Int. 1991;39:253-8.
36. Sunahara RK, Guan HC, O'Dowd BF, et al. Cloning of the genefor a human dopamine D5 receptor with higher affinity fordopamine than D1. Nature. 1991;350:614-9. (Pubitemid 21912283)
37. Sanada H, Xu J, Watanabe H, et al. Differential expression and regulation of dopamine-1 (D-1) and dopamine-5 (D-5) receptor function in human kidney. Am J Hypertens. 2000;13:156A.
38. Tiberi M, Caron MG. High agonist-independent activity is adistinguishing feature of the dopamine D1B receptor subtype. JBiol Chem. 1994;269:27925-31. (Pubitemid 24354519)
39. Moore JH, Williams SM. New strategies for identifying gene-gene interactions in hypertension. Ann Med. 2002;34:88-99.
40. Ladines CA, Zeng C, Asico LD, et al. Impaired renal D1-likeand D2-like dopamine receptor interaction in the spontaneouslyhypertensive rat. Am J Physiol Regulatory Integrative CompPhysiol. 2001;281:R1071-8.
41. Eklof AC. The natriuretic response to a dopamine DA1 agonist requires endogenous activation of dopamine DA2 receptors.Acta Physiol Scand. 1997;160:311-4.
42. Bacic D, Kaissling B, McLeroy P, et al. Dopamine acutelydecreases apical membrane Na/H exchanger NHE3 protein inmouse renal proximal tubule. Kidney Int. 2003;64:2133-41. (Pubitemid 37449547)
43. Felder CC, Albrecht FE, Campbell T, et al. Cyclic AMPindependent,G protein-linked inhibition of Na+/H+ exchange inrenal brush border by D1 dopamine agonists. Am J Physiol.1993;264:F1032-7. (Pubitemid 23198551)
44. Bacic D, Capuano P, Baum M, et al. Activation of dopamine D1-like receptors induces acute internalization of the renal Na+/phosphate cotransporter NaPi-IIa in mouse kidney and OK cells.Am J Physiol Renal Physiol. 2005;288:F740-7. (Pubitemid 40381741)
45. Pedrosa R, Jose PA, Soares-da-Silva P. Defective D1-likereceptor-mediated inhibition of the Cl-/HCO3- exchanger inimmortalized SHR proximal tubular epithelial cells. Am J Physiol Renal Physiol. 2004;286:F1120-6. (Pubitemid 38656368)
46. Efendiev R, Cinelli AR, Leibiger IB, et al. FRET analysis revealsa critical conformational change within the Na, K-ATPase a1subunit N-terminus during GPCR-dependent endocytosis. FEBSLett. 2006;580:5067-70. (Pubitemid 44348973)
47. Asghar M, Hussain T, Lokhandwala MF. Activation of dopamineD1-like receptor causes phosphorylation of a1-subunit of Na+,K+-ATPase in rat renal proximal tubules. Eur J Pharmacol.2001;411:61-6. (Pubitemid 32013112)
48. Kunimi M, Seki G, Hara C, et al. Dopamine inhibits renal Na+:HCO3- cotransporter in rabbits and normotensive rats but not inspontaneously hypertensive rats. Kidney Int. 2000;57:534-43. (Pubitemid 30430645)
49. Wang ZQ, Felder RA, Carey RM. Selective inhibition of therenal dopamine subtype D1A receptor induces antinatriuresis inconscious rats. Hypertension. 1999;33:504-10. (Pubitemid 29065711)
50. Crambert S, Sjöberg A, Eklöf AC, et al. Prolactin and dopamine1-like receptor interaction in renal proximal tubular cells. Am JPhysiol Renal Physiol. 2010;299:F49-54.
51. ·· Li H, Armando I, Yu P, et al. Dopamine 5 receptor mediatesAng II type 1 receptor degradation via a ubiquitin-proteasomepathway in mice and human cells. J Clin Invest. 2008;118:2180-9. This article demonstrates counterregulation between thedopamine D5 receptor and the AT1 receptor as a mechanismof blood pressure regulation. (Pubitemid 351872336)
52. Zeng C, Wang Z, Hopfer U, et al. Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalizedrenal proximal tubule cells. Hypertension. 2005;46:799-805. (Pubitemid 43186755)
53. Zeng C, Liu Y, Wang Z, et al. Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in ratrenal proximal tubule cells. Circ Res. 2006;99:494-500. (Pubitemid 44337821)
54. Khan F, Spicarova Z, Zelenin S, et al. Negative reciprocitybetween angiotensin II type 1 and dopamine D1 receptors in ratrenal proximal tubule cells. Am J Physiol Renal Physiol.2008;295:F1110-F1116. This study shows that the dopamine D1receptor and the AT1 receptor coimmunoprecipitate, and thatD1-like stimulation counterregulates a well-known effect of theAT1 receptor, namely calcium signaling.
55. Hollon TR, Bek MJ, Lachowicz JE, Ariano MA, Mezey E,Ramachandran R, et al. Westphal H, Jose PA, Sibley DR:Mice lacking D5 dopamine receptors have increased sympathetictone and are hypertensive. J Neurosci. 2002;22:10801-10.
56. Yang Z, Asico LD, Yu P, Wang Z, Jones JE, Escano CS, et al. D5 dopamine receptor regulation of reactive oxygen species production, NADPH oxidase, and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2006;290:R96-R104.
57. Zeng C, Yang Z, Wang Z, Jones J, Wang X, Altea J, et al.Interaction of angiotensin II type 1 and D5 dopamine receptorsin renal proximal tubule cells. Hypertension. 2005;45:804-10. (Pubitemid 40418385)
58. Wang X, Luo Y, Escano CS, Yang Z, Asico L, Li H, et al.Upregulation of renal sodium transporters in D5 dopaminereceptor-deficient mice. Hypertension. 2010;55:1431-7. Thisarticle shows that ablation of the D5 receptor in mice increasesboth AT1 receptor and sodium transporters/channels contributingto hypertension.
59. Chugh G, Lokhandwala MF, Asghar M. Oxidative stress altersrenal D1 and AT1 receptor functions and increases bloodpressure in old rats. Am J Physiol Renal Physiol. 2011;300:F133-138. This article investigates the causal role of ageassociatedoxidative stress in exaggerated renal AT1 receptorfunction and diminished D1 receptor function, contributing tohypertension in old rats.
60. Hakam AC, Siddiqui AH, Hussain T: Renal angiotensin II AT2 receptors promote natriuresis in streptozotocin-induced diabeticrats. Am J Physiol Renal Physiol 2006, 290:F503-F508. This article describes the mechanism of AT2 receptor-mediatednatriuresis and diuresis. (Pubitemid 43725004)
61. Hakam AC, Hussain T. Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats. Hypertension. 2005;45:270-5. (Pubitemid 40179971)
62. Salomone LJ, Howell NL, McGrath HE, et al. Intrarenaldopamine D1-like receptor stimulation induces natriuresis viaan angiotensin type-2 receptor mechanism. Hypertension.2007;49:155-61. (Pubitemid 46360355)
63. Padia SH, Howell NL, Siragy HM, Carey RM. Renal angiotensintype 2 receptors mediate natriuresis via angiotensin III in theangiotensin II type 1 receptor-blocked rat. Hypertension.2006;47:537-44. (Pubitemid 43843872)
64. Citarella MR, Choi MR, Gironacci MM, et al. Urodilatin and dopamine: a new interaction in the kidney. Regul Pept.2009;153:19-24.
65. Yao B, Harris RC, Zhang MZ. Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase2 pathway. Hypertension. 2009;54:1077-83.
66. Kirchheimer C, Mendez CF, Acquier A, et al. Role of 20-HETEin D1/D2 dopamine receptor synergism resulting in the inhibition of Na+-K+-ATPase activity in the proximal tubule. Am J Physiol Renal Physiol. 2007;292:F1435-42. (Pubitemid 46701871)
67. Venkatakrishnan U, Chen C, Lokhandwala MF. The role ofintrarenal nitric oxide in the natriuretic response to dopaminereceptor activation. Clin Exp Hypertens. 2000;22:309-24. (Pubitemid 30305954)
68. Marwaha A, Lokhandwala MF. Diminished natriuretic responseto dopamine D1 receptor agonist, SKF-38393 in obese Zuckerrats. Clin Exp Hypertens. 2003;25:509-15. (Pubitemid 37443138)
69. Marwaha A, Banday AA, Lokhandwala MF. Reduced renaldopamine D1 receptor function in streptozotocin-induced diabeticrats. Am J Physiol Renal Physiol. 2004;286:F451-7. (Pubitemid 38233637)
70. Moreira-Rodrigues M, Quelhas-Santos J, Serrão P, Fernandes-Cerqueira C, Sampaio-Maia B, Pestana M. Glycaemic controlwith insulin prevents the reduced renal dopamine D1 receptorexpression and function in streptozotocin-induced diabetes.Nephrol Dial Transplant. 2010;25:2945-53.
71. Hahn RA, Wardell Jr JR. Sarau HM, Ridley PT: Characterization of the peripheral and central effects of SK&F 82526, a noveldopamine receptor agonist. J Pharmacol Exp Ther. 1982;223:305-13. (Pubitemid 12005726)
72. Murphy MB, Murray C, Shorten GD. Fenoldopam: a selectiveperipheral dopamine-receptor agonist for the treatment of severehypertension. N Engl J Med. 2001;345:1548-57. (Pubitemid 33144922)
73. Yaqoob M, McClelland P, Ahmad R. Delayed recovery of renal function in patients with acute renal failure due to accelerated hypertension. Postgrad Med J. 1991;67:829-32.
74. Bakir AA, Bazilinski N, Dunea G. Transient and sustainedrecovery from renal shutdown in accelerated hypertension. Am JMed. 1986;80:172-6. (Pubitemid 16140761)
75. Reisin E, Huth MM, Nguyen BP, Weed SG, Gonzalez FM.Intravenous fenoldopam versus sodium nitroprusside in patientswith severe hypertension. Hypertension. 1990;15(Suppl):I59-62.
76. Zeng C, Armando I, Luo Y, et al. Dysregulation of dopamine dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol. 2008;294:H551-69. (Pubitemid 351253262)
77. Ueda A, Ozono R, Oshima T, et al. Disruption of the type 2dopamine receptor gene causes a sodium-dependent increase inblood pressure in mice. Am J Hypertens. 2003;16:853-8. (Pubitemid 37204683)
78. Staudacher T, Pech B, Tappe M, et al. Arterial blood pressure and renal sodium excretion in dopamine D3 receptor knockoutmice. Hypertens Res. 2007;30:93-101.
79. Sunahara RK, Niznik HB, Weiner DM, et al. Human dopamineD1 receptor encoded by an intronless gene on chromosome 5.Nature. 1990;347:80-3.
80. ·· Kiryluk K: Renal function and genetic variation in dopamineD(1) receptor: is the case strong enough? Kidney Int 2009,76:1019-1022. This article reviews the role of DRD1 genepolymorphisms in blood pressure regulation.
81. Fung MM, Rana BK, Tang C-M, et al. Dopamine D1 receptor(DRD1) genetic polymorphism: pleiotropic effects on heritablerenal traits. Kidney Int. 2009;76:1070-80.
82. Rao F, Wessel J, Wen G, et al. Renal albumin excretion: twin studies identify influences of heredity, environment, and adrenergicpathway polymorphism. Hypertension. 2007;49:1015-31. (Pubitemid 351664306)
83. Staessen JA, Kuznetsova T, Zhang H, et al. Blood pressure andrenal sodium handling in relation to genetic variation in theDRD1 promoter and GRK4. Hypertension. 2008;51:1643-50.
84. Sen S, Nesse R, Sheng L, et al. Association between adopamine-4 receptor polymorphism and blood pressure. Am J Hypertens. 2005;18:1206-10. (Pubitemid 41337974)
85. Banday AA, Lau YS, Lokhandwala MF. Oxidative stress causesrenal dopamine D1 receptor dysfunction and salt-sensitivehypertension in Sprague-Dawley rats. Hypertension.2008;51:367-75. (Pubitemid 351159952)
86. Banday AA, Lokhandwala MF. Dopamine receptors and hypertension.Curr Hypertens Rep. 2008;10:268-75.
87. · Jose PA, Soares-da-Silva P, Eisner GM, Felder RA: Dopamineand G protein-coupled receptor kinase 4 in the kidney: role inblood pressure regulation. Biochim Biophys Acta 2010,1802:1259-1267. This article reviews the role of GRK4 genevariants in regulating blood pressure.
88. O'Connell DP, Ragsdale NV, Boyd DG, et al. Differential humanrenal tubular responses to dopamine type 1 receptor stimulationare determined by blood pressure status. Hypertension. 1997;29(1 Pt 1):115-22. (Pubitemid 27078351)
89. Felder RA, Sanada H, Xu J, et al. G protein-coupled receptorkinase 4 gene variants in human essential hypertension. ProcNatl Acad Sci USA. 2002;99:3872-7. (Pubitemid 34252198)
90. Felder RA, Seikaly MG, Cody P, et al. Attenuated renal responseto dopaminergic drugs in spontaneously hypertensive rats.Hypertension. 1990;15:560-9. (Pubitemid 20187600)
91. Chen C, Lokhandwala MF. An impairment of renal tubular DA-1receptor function as the causative factor for diminished natriuresisto volume expansion in spontaneously hypertensive rats. ClinExp Hypertens. 1992;14:615-28.
92. Nishi A, Eklof AC, Bertorello AM, Aperia A. Dopamineregulation of renal Na+, K+-ATPase activity is lacking in Dahlsalt-sensitive rats. Hypertension. 1993;21:767-71. (Pubitemid 23171638)
93. Chen C, Beach RE, Lokhandwala MF. Dopamine fails to inhibitrenal tubular sodium pump in hypertensive rats. Hypertension.1993;21:364-72. (Pubitemid 23065177)
94. Xu J, Li XX, Albrecht FE, et al. Dopamine1 receptor, GSá, andNa+-H+ exchanger interactions in the kidney in hypertension. Hypertension. 2000;36:395-9.
95. Sanada H, Jose PA, Hazen-Martin D, et al. Dopamine-1 receptorcoupling defect in renal proximal tubule cells in hypertension.Hypertension. 1999;33:1036-42. (Pubitemid 29186405)
96. Zhu H, Lu Y, Wang X, et al. The G protein-coupled receptorkinase 4 gene modulates stress-induced sodium excretion inblack normotensive adolescents. Pediatr Res. 2006;60:440-2. (Pubitemid 44427597)
97. Sanada H, Yatabe J, Midorikawa S, et al. Single-nucleotidepolymorphisms for diagnosis of salt-sensitive hypertension. ClinChem. 2006;52:352-60.
98. Rana BK, Insel PA, Payne SH, et al. Population-based samplereveals gene-gender interactions in blood pressure in whiteAmericans. Hypertension. 2007;49:96-106. (Pubitemid 46360347)
99. Marques FZ, Campain AE, Yang YH, et al. Meta-analysis of genome-wide gene expression differences in onset and maintenancephases of genetic hypertension. Hypertension.2010;56:319-24.
100. Bengra C, Mifflin TE, Khripin Y, et al. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. ClinChem. 2002;48:2131-40. (Pubitemid 35397554)
101. kB and Nrf2, on D1 receptor function regulation.
102. White BH, Sidhu A. Increased oxidative stress in renal proximal tubules of the spontaneously hypertensive rat: a mechanism fordefective dopamine D1A receptor/G-protein coupling. J Hypertens.1998;16:1659-65. (Pubitemid 28515493)
103. Asghar M, Banday AA, Fardoun RZ, Lokhandwala MF. Hydrogen peroxide causes uncoupling of dopamine D1-like receptors from G proteins via a mechanism involving protein kinase C and G-protein-coupled receptor kinase 2. Free Radic Biol Med. 2006;40:13-20. (Pubitemid 41759399)
104. Fardoun RZ, Asghar M, Lokhandwala M. Role of oxidative stress in defective renal dopamine D1 receptor-G protein coupling and function in old Fischer 344 rats. Am J PhysiolRenal Physiol. 2006;291:F945-51. (Pubitemid 44772027)
105. Banday AA, Marwaha A, Tallam LS, Lokhandwala MF. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes. 2005;54:2219-26. (Pubitemid 40911287)
106. George L, Lokhandwala MF, Asghar M. Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats. Am J Physiol Renal Physiol.2009;297:F1174-80.
107. Muhammad AB, Lokhandwala MF, Banday AA. Exercise reduces oxidative stress but does not alleviate hyperinsulinemiaor renal dopamine D1 receptor dysfunction in obese rats. Am J Physiol Renal Physiol. 2011;300:F98-F104.
108. Watanabe H, Xu J, Bengra C, Jose PA, Felder RA. Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. Kidney Int. 2002;62:790-8. (Pubitemid 35316708)
109. Trivedi M, Lokhandwala MF. Rosiglitazone restores renal D1A receptor-Gs protein coupling by reducing receptor hyperphosphorylationin obese rats. Am J Physiol Renal Physiol. 2005;289:F298-304. (Pubitemid 41003659)
110. Yasunari K, Kohno M, Kano H, Minami M, Yoshikawa J. Dopamine as a novel antioxidative agent for rat vascular smooth muscle cells through dopamine D(1)-like receptors. Circulation.2000;101:2302-8. (Pubitemid 30317134)
111. Yatabe J, Sanada H, Yatabe MS, Hashimoto S, Yoneda M, Felder RA, et al. Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol. 2009;296:F1052-60.