Correlation of carotid atheromatous plaque inflammation using USPIO-enhanced MR imaging with degree of luminal Stenosis

Stroke

Volumn 39, Issue 7, 2008, Pages 2144-2147

  Tang, Tjun Y ^a   Howarth, Simon P S ^a   Miller, Sam R ^b   Graves, Martin J ^a   U King Im, Jean Marie ^a   Li, Zhi Yong ^a   Walsh, Stewart R ^a   Patterson, Andrew J ^a   Kirkpatrick, Peter J ^a   Warburton, Elizabeth A ^a   Varty, Kevin ^a   Gaunt, Michael E ^a   Gillard, Jonathan H ^a  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Asymptomatic carotid stenosis; Atherosclerosis; Inflammation; MRI; Plaque vulnerability; USPIO

Indexed keywords

ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; FERRIC ION; FERRIC OXIDE;

ADULT; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; CAROTID ARTERY OBSTRUCTION; COHORT ANALYSIS; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RISK FACTOR; ATHEROSCLEROSIS; CAROTID ARTERY; CHEMISTRY; IMAGE PROCESSING; LETTER; METHODOLOGY; MIDDLE AGED; PATHOLOGY; STENOSIS, OCCLUSION AND OBSTRUCTION;

AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; CAROTID ARTERIES; COHORT STUDIES; CONSTRICTION, PATHOLOGIC; FEMALE; FERRIC COMPOUNDS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; RISK FACTORS;

EID: 47649104588     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.504753     Document Type: Article

References (6)

1. Nighoghossian N, Derex L, Douek P. The vulnerable carotid artery plaque: Current imaging methods and new perspectives. Stroke. 2005;36: 2764-2772.
2. Trivedi RA, Mallawarachi C, U-King-Im JM, Graves MJ, Horsley J, Goddard MJ, Brown A, Wang L, Kirkpatrick PJ, Brown J, and Gillard JH. Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages. Arterioscler Thromb Vasc Biol. 2006;26:1601-1606.
3. Tang T, Howarth SP, Miller SR, Trivedi R, Graves MJ, U-King-Im JM, Li ZY, Brown AP, Kirkpatrick PJ, Gaunt ME, Gillard JH. Assessment of inflammatory burden contralateral to the symptomatic carotid stenosis using high-resolution ultrasmall, superparamagnetic iron oxide-enhanced MRI. Stroke. 2006;37:2266-2270.
4. Tang T, Howarth S, Miller S, Graves M, U-King-Im JM, Trivedi R, Li Z, Walsh S, Brown A, Kirkpatrick P, Gaunt M, Gillard J. Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques contralateral to symptomatic carotid stenosis: An ultrasmall superparamagnetic iron oxide enhanced magnetic resonance study. J Neurol Neurosurg Psychiatry. In press.
5. Hatsukami TS, Ross R, Polissar NL, Yuan C. Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation. 2000;102: 959-964.
6. U-King-Im JM, Trivedi RA, Sala E, Graves MJ, Gaskarth M, Higgins NJ, Cross JC, Hollingworth W, Coulden RA, Kirkpatrick PJ, Antoun NM, Gillard JH. Evaluation of carotid stenosis with axial high-resolution black-blood mr imaging. Eur Radiol. 2004;14:1154-1161.