Effect of hydroalcoholic and buthanolic extract of Cucumis sativus seeds on blood glucose level of normal and streptozotocin-induced diabetic rats

Iranian Journal of Basic Medical Sciences

Volumn 14, Issue 5, 2011, Pages 436-442

  Minaiyan, Mohsen ^a   Zolfaghari, Behzad ^a   Kamal, Amin ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Animal model; Blood glucose; Diabetes mellitus; Hypoglycemic agents; Plant extract

Indexed keywords

ALCOHOL; CUCUMIS SATIVUS EXTRACT; GLIBENCLAMIDE; GLUCOSE; PLANT EXTRACT; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CUCUMBER; GLUCOSE BLOOD LEVEL; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PLANT SEED; RAT;

ANIMALIA; CUCUMIS SATIVUS; RATTUS; RATTUS NORVEGICUS;

EID: 80052528557     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Zimmet P, Alberti KG, Shaw J. Global and social implications of the diabetes epidemic. Nature 2001; 414:782-787.
2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004; 27:1047-1053.
3. Esteghamati A, Gouya MM, Abbasi M, Delavari A, Alikhani S, Alaedini F, et al. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National survey of risk factors for non-communicable diseases of Iran. Diabetes Care 2008; 31:96-98.
4. Rang HP, Dale MM, Ritter JM, Moore PK. Pharmacology.5th ed.London: Churchill Livingstone; 2003. 386-387.
5. Khan A, Safdar M. Role of diet, nutrients, spices and natural products in diabetes mellitus. Pakistan J Nutr? 2003; 2:1-12.
6. Narendhirakannan RT, Subramanian S, Kandaswamy M. Biochemical evaluation of antidiabetic properties of some commonly used Indian plants on streptozotocin-induced diabetes in experimental rats. Clin Exp Pharmacol Physiol 2006; 33:1150-1157.
7. Trease GE, Evans WC. Trease and evans pharmacognosy. 15th ed. London: WB Saunders; 2002. p. 419-420, 469,473.
8. Ghassemi-Dehkordi N, Moattar F, Mohagheghzadeh AA. General methods in pharmacognosy. In Iranian herbal pharmacopea scientific committee, editors. Iranian herbal pharmacopeae. 1st ed. Tehran: Iranian Minstry of Health Publications; 2002. p. 25.
9. Xia T, Wang Q. Antihyperglycemic effect of Cucurbita ficifolia fruit extract in streptozotocin-induced diabetic rats. Fitoterapia 2006; 77:530-533.
10. Acosta-Patino JL, Jimenese-Balderas E, Juarez-Oropeza MA, Diaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. J Ethnopharmacol 2001; 77:99-101.
11. Chen Q, Chan LL, Li ET. Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet. J Nutr 2003; 133:1088-1093.
12. Miura T, Itoh C, Iwamoto N, Kato M, Kawai M, Park SR, et al. Hypoglycemic activity of the fruit of the Mamordica charantia in type 2 diabetic mice. J Nutr Sci Vitaminol 2001; 47:340-344.
13. Dixit Y, Kar A. Protective role of three vegetable peels in alloxan-induced diabetes mellitus in male mice. Plant Foods Hum Nutr 2010; 65: 284-9.
14. Han C, Hui Q, Wang Y. Hypoglycemic activity of saponin fraction extracted from Momordica charantia in PEG/salt aqueous two-phase systems. Nat Prod Res 2008; 22:1112-1119.
15. Abou-Zaid MM, Lombardo DC, Kite GJ, Grayer RC, Veitch N. Acylated flavone C-glycosides from Cucumis sativus. Phytochemistry 2001; 58:167-172.
16. Roman-Ramos R, Florea-Saenz JL, Alarcon-Aquilar FJ. Anti-hyperglycemic effect of some edible plants. J Ethnopharmacol 1995; 48:25-32.
17. Amin GhR. Popular traditional plants of Iran. 5th ed. Tehran: Tehran University of Medical Sciences Publications; 2005.
18. Jazaeri GhD. Language of foods. 1st ed. Tehran: Amir Kabir Publications; 1982.
19. Sudheesh S, Vijayalakshmi NR. Role of pectin from cucumber (Cucumis sativus) in modulation of protein kinase C activity and regulation of glycogen metabolism in rats. Indian J Biochem Biophys. 2007; 44:183-185.
20. Chandrasekar B, Mukherjee B, Mukherjee SK. Blood sugar lowering potentiality of selected Cucurbitacea plants of India origin. Indian J Med Res 1989; 90:300-305.
21. Harborne J. Phytochemical methods: a guide to modern techniques of plant analysis. 5th ed. London and New York: Springer; 1998.
22. Movahedian A, Zolfaghari B, Sajjadi SE, Moknatjou R. Antihyperlipidemic effect of Peucedanum pastinacifolium extract in streptozotocin-induced diabetic rats. Clinics 2010; 65:629-633.
23. Vats V, Yadav SP, Grover JK. Ethanolic extract of Ocimim sanctum leaves partially attenuates streptozotocininduced alterations in glycogen content and carbohydrate methabolism in rats. J Ethnopharmacol 2004; 90:155-160.
24. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 1969; 22:158-161.
25. Salahuddin M, Jalalpure SS. Antidiabetic activity of aqueous fruit extract of Cucumis trigonus Roxb. in streptozotocin-induced diabetic rats. J Ethnopharmacol 2010; 127:565-567.
26. Nolte MS, Karam JH. Pancreatic hormones and antidiabetic drugs. In: Katzung BG, editor. Basic and clinical pharmacology. 9th ed. New York: McGraw Hill Companies; 2004. p.708.
27. Davis SN, Granner DK. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman & Gilman's the pharmacological basis of therapeutics. 10th ed. New York: McGraw Hill Companies; 2002.p. 1687-1690.