Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects

European Journal of Cancer

Volumn 47, Issue 14, 2011, Pages 2240-2247

  Zhou, Qian Mei ^a   Wang, Xiu Feng ^a   Liu, Xin Jun ^a   Zhang, Hui ^a   Lu, Yi Yu ^a   Huang, Shuang ^b   Su, Shi Bing ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Combination; Curcumin; Mitomycin C; Side effects

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CASPASE 8; CASPASE 9; CREATININE; CURCUMIN; MITOMYCIN C; PROTEIN BAX; PROTEIN BCL 2;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BREAST CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; KIDNEY FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL LINE, TUMOR; CHEMOPREVENTION; CHEMOTHERAPY, ADJUVANT; CURCUMIN; DRUG SYNERGISM; FEMALE; HUMANS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; MITOMYCIN;

EID: 80052528373     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2011.04.032     Document Type: Article

References (31)

1. M. Volpato, J. Seargent, P.M. Loadman, and R.M. Phillips Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity Eur J Cancer 41 2005 1331 1338 (Pubitemid 40813011)
2. F. Perrone, S. De Placido, and C. Carlomagno Mitomycin C and mitoxantrone in anthracycline-pretreated advanced breast cancer patients. A phase II study Am J Clin Oncol 17 1994 218 222 (Pubitemid 24160611)
3. J. Verwey, J. de Vries, and H.M. Pinedo Mitomycin C-induced renal toxicity, a dose-dependent side effect? Eur J Cancer Clin Oncol 23 1987 195 199 (Pubitemid 17229907)
4. K. Yoshinaka, M. Yagi, S. Ohtagaki, M. Toi, and T. Toge 5′-Deoxy-5-fluorouridine (5′-DFUR), mitomycin C (MMC), etoposide and medroxy progesterone acetate (MPA) in a previously treated patient with advanced breast cancer Gan To Kagaku Ryoho 18 1991 115 158
5. M. Lopez, P. Papaldo, and L. Di Lauro Mitomycin C in patients with metastatic breast cancer refractory to hormone therapy and chemotherapy Oncology 40 1983 244 247 (Pubitemid 13026392)
6. F.C. Campbell, and G.P. Collett Chemopreventive properties of curcumin Future Oncol 1 2005 405 414
7. I. Vis, P. Sriganth, and B. Premalatha Dietary curcumin with cisplatin administration modulates tumour marker indices in experimental fibrosarcoma Pharmacol Res 39 1999 175 179 (Pubitemid 29119021)
8. I. Tamm, F. Schriever, and B. Dorken Apoptosis: implications of basic research for clinical oncology Lancet Oncol 2 2001 33 42 (Pubitemid 33585915)
9. N.A. Thornberry, and Y. Lazebnik Caspases: enemies within Science 281 1998 1312 1316 (Pubitemid 28406817)
10. A. Strasser, A.W. Harris, D.C. Huang, P.H. Krammer, and S. Cory Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis EMBO J 14 1995 6136 6147 (Pubitemid 26007301)
11. F. Pirnia, E. Schneider, D.C. Betticher, and M.M. Borner Mitomycin C induces apoptosis and caspase-8 and -9 processing through a caspase-3 and Fas-independent pathway Cell Death Differ 9 2002 905 914 (Pubitemid 35023606)
12. T.I. Kim, S.I. Choi, H.K. Lee, Y.J. Cho, and E.K. Kim Mitomycin C induces apoptosis in cultured corneal fibroblasts derived from type II granular corneal dystrophy corneas Mol Vis 14 2008 1222 1228 (Pubitemid 351984376)
13. T.W. Tan, H.R. Tsai, and H.F. Lu Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation Anticancer Res 26 2006 4361 4371
14. R.J. Anto, A. Mukhopadhyay, K. Denning, and B.B. Aggarwal Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl Carcinogenesis 23 2002 143 150 (Pubitemid 34213563)
15. Yang L, Wei DD, Chen Z, Wang JS, Kong LY. Reversal of multidrug resistance in human breast cancer cells by Curcuma wenyujin and Chrysanthemum indicum. Phytomedicine. 2011 Feb 7. [Epub ahead of print].
16. T.C. Chou, and P. Talalay Quantitative analysis of dose-effect relationship: the combined effects of multiple drugs or enzyme inhibitors Adv Enzyme Regul 22 1984 27 55
17. Janet E. Price, Aristidis Polyzos, Ruo Dan Zhang, and Lisa M. Daniels Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice Cancer Res 50 1990 717 721 (Pubitemid 20054204)
18. Jianmin Chen, Evon Hui, Terence Ip, and Lilian U. Thompson Dietary flaxseed enhances the inhibitory effect of tamoxifen on the growth of estrogen-dependent human breast cancer (MCF-7) in nude mice Clin Cancer Res 10 2004 7703 7711 (Pubitemid 39557535)
19. K. Singletary, C. MacDonald, M. Wallig, and C. Fisher Inhibition of 7,12-dimethylbenzaanthracene (DMBA)-induced mammary tumorigenesis and DMBA-DNA adduct formation by curcumin Cancer Lett 103 1996 137 141
20. P. Chanvorachote, V. Pongrakhananon, and S. Wannachaiyasit Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation Cancer Invest 27 2009 624 635
21. Sreekanth CN, Bava SV, Sreekumar E, Anto RJ.Molecular evidences for the chemosensitizing efficacy of liposomal curcumin in paclitaxel chemotherapy in mouse models of cervical cancer. Oncogene 2011 February 14 [Epub ahead of print].
22. A. Cabrespine-Faugeras, M. Bayet-Robert, J.O. Bay, P. Chollet, and C. Barthomeuf Possible benefits of curcumin regimen in combination with taxane chemotherapy for hormone-refractory prostate cancer treatment Nutr Cancer 62 2 2010 148 153
23. L.M. Antunes, J.D. Darin, and L. Bianchi Nde Effects of the antioxidants curcumin or selenium on cisplatin-induced nephrotoxicity and lipid peroxidation in rats Pharmacol Res 43 2001 145 150 (Pubitemid 32601443)
24. H. Inano, M. Onoda, and N. Inafuku Chemoprevention by curcumin during the promotion stage of tumorigenesis of mammary gland in rats irradiated with gammarays Carcinogenesis 1999 1011 1018 (Pubitemid 29263744)
25. C.V. Rao, A. Rivenson, B. Simi, and B.S. Reddy Chemoprevention of colon cancer by dietary curcumin Ann NY Acad Sci 1995 201 204 (Pubitemid 26078732)
26. C.P. Prasad, G. Rath, S. Mathur, D. Bhatnagar, and R. Ralhan Expression analysis of Maspin in Invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines Chem Biol Interact 183 2010 455 461
27. S. Welz, T. Hehr, and C. Kollmannsberger Renal toxicity of adjuvant chemoradiotherapy with cisplatin in gastric cancer Int J Radiat Oncol Biol Phys 69 2007 1429 1435 (Pubitemid 350116407)
28. B.B. Aggarwal, Y.H. Surh, and S. Shishodia The molecular targets and therapeutics of curcumin in health and disease Adv Exp Med Biol 2007 995
29. N.M. Weir, K. Selvendiran, and V.K. Kutala Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK Cancer Biol Ther 6 2007 178 184 (Pubitemid 46641620)
30. T.I. Kim, S.I. Choi, H.K. Lee, Y.J. Cho, and E.K. Kim Apoptosis in keratocytes caused by mitomycin C Invest Ophthalmol Vis Sci 44 2003 1912 1917
31. J. Liu, Q. Wang, and X. Wang Apoptosis of bladder cancer cells induced by short-term and low-dose Mitomycin-C: potential molecular mechanism and clinical implication Int J Mol Med 11 2003 389 394