B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Frey, Oliver ^a   Bruns, Lisa ^a   Morawietz, Lars ^b   Dunussi Joannopoulos, Kyri ^c   Kamradt, Thomas ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD22 ANTIGEN; GLUCOSE 6 PHOSPHATE ISOMERASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; B CELL DEPLETION; CELL SELECTION; CELL SPECIFICITY; CELL VIABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HELPER CELL; HISTOPATHOLOGY; IMMUNOMODULATION; IN VIVO STUDY; LYMPHOCYTE COUNT; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; RHEUMATOID ARTHRITIS; THERAPY EFFECT; ANIMAL; ANTIBODY PRODUCTION; ARTHRITIS; B LYMPHOCYTE; IMMUNOLOGY; METABOLISM;

ANIMALIA; MUS;

ANIMALS; ANTIBODY FORMATION; ARTHRITIS; B-LYMPHOCYTES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GLUCOSE-6-PHOSPHATE ISOMERASE; MICE;

EID: 80052526257     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024718     Document Type: Article

References (30)

1. Westermann J, Pabst R, (1990) Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol Today 11: 406-410.
2. Dunussi-Joannopoulos K, Hancock GE, Kunz A, Hegen M, Zhou XX, et al. (2005) B-cell depletion inhibits arthritis in a collagen-induced arthritis (CIA) model, but does not adversely affect humoral responses in a respiratory syncytial virus (RSV) vaccination model. Blood 106: 2235-2243.
3. Bouaziz JD, Yanaba K, Venturi GM, Wang Y, Tisch RM, et al. (2007) Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice. Proc Natl Acad Sci U S A 104: 20878-20883.
4. Hamel K, Doodes P, Cao Y, Wang Y, Martinson J, et al. (2008) Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity. J Immunol 180: 4994-5003.
5. Huang H, Benoist C, Mathis D, (2010) Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proc Natl Acad Sci U S A 107: 4658-4663.
6. Schubert D, Maier B, Morawietz L, Krenn V, Kamradt T, (2004) Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol 172: 4503-4509.
7. Bockermann R, Schubert D, Kamradt T, Holmdahl R, (2005) Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase. Arthritis Res Ther 7: R1316-1324.
8. Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, et al. (2002) How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol 3: 360-365.
9. Matsumoto I, Staub A, Benoist C, Mathis D, (1999) Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science 286: 1732-1735.
10. Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, et al. (2002) Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med 195: 1071-1077.
11. Tedder TF, Poe JC, Haas KM, (2005) CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol 88: 1-50.
12. Fiorina P, Vergani A, Dada S, Jurewicz M, Wong M, et al. (2008) Targeting CD22 reprograms B-cells and reverses autoimmune diabetes. Diabetes 57: 3013-3024.
13. Symington FW, Subbarao B, Mosier DE, Sprent J, (1982) Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody. Immunogenetics 16: 381-391.
14. Frey O, Meisel J, Hutloff A, Bonhagen K, Bruns L, et al. (2010) Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Ann Rheum Dis 69: 1495-1501.
15. Bruns L, Frey O, Morawietz L, Landgraf C, Volkmer R, et al. (2009) Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther 11: R117.
16. Frentsch M, Arbach O, Kirchhoff D, Moewes B, Worm M, et al. (2005) Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med 11: 1118-1124.
17. Kirchhoff D, Frentsch M, Leclerk P, Bumann D, Rausch S, et al. (2007) Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur J Immunol 37: 2370-2377.
18. Tanaka-Watanabe Y, Matsumoto I, Iwanami K, Inoue A, Goto D, et al. (2009) B cells play a crucial role as antigen-presenting cells and collaborate with inflammatory cytokines in glucose-6-phosphate isomerase-induced arthritis. Clin Exp Immunol 155: 285-294.
19. Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, et al. (2008) Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum 58: 754-763.
20. Silverman GJ, Boyle DL, (2008) Understanding the mechanistic basis in rheumatoid arthritis for clinical response to anti-CD20 therapy: the B-cell roadblock hypothesis. Immunol Rev 223: 175-185.
21. Chattopadhyay PK, Yu J, Roederer M, (2005) A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles. Nat Med 11: 1113-1117.
22. Mittrucker HW, Steinhoff U, Kohler A, Krause M, Lazar D, et al. (2007) Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis. Proc Natl Acad Sci U S A 104: 12434-12439.
23. Gaucher D, Therrien R, Kettaf N, Angermann BR, Boucher G, et al. (2008) Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses. J Exp Med 205: 3119-3131.
24. Tokoyoda K, Zehentmeier S, Hegazy AN, Albrecht I, Grun JR, et al. (2009) Professional memory CD4+ T lymphocytes preferentially reside and rest in the bone marrow. Immunity 30: 721-730.
25. Lanzavecchia A, (1990) Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu Rev Immunol 8: 773-793.
26. Nandakumar KS, Johansson BP, Bjorck L, Holmdahl R, (2007) Blocking of experimental arthritis by cleavage of IgG antibodies in vivo. Arthritis Rheum 56: 3253-3260.
27. Hietala MA, Jonsson IM, Tarkowski A, Kleinau S, Pekna M, (2002) Complement deficiency ameliorates collagen-induced arthritis in mice. J Immunol 169: 454-459.
28. Kleinau S, Martinsson P, Heyman B, (2000) Induction and suppression of collagen-induced arthritis is dependent on distinct fcgamma receptors. J Exp Med 191: 1611-1616.
29. Magnusson SE, Andren M, Nilsson KE, Sondermann P, Jacob U, et al. (2008) Amelioration of collagen-induced arthritis by human recombinant soluble FcgammaRIIb. Clin Immunol 127: 225-233.
30. Diaz de Stahl T, Andren M, Martinsson P, Verbeek JS, Kleinau S, (2002) Expression of FcgammaRIII is required for development of collagen-induced arthritis. Eur J Immunol 32: 2915-2922.