Genetic background strongly modifies the severity of symptoms of hirschsprung disease, but not hearing loss in rats carrying Ednrb sl mutations

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Dang, Ruihua ^a   Torigoe, Daisuke ^a   Suzuki, Sari ^b   Kikkawa, Yoshiaki ^b,c   Moritoh, Kanako ^a   Sasaki, Nobuya ^a   Agui, Takashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; ENDOTHELIN B RECEPTOR; MICROSATELLITE DNA;

AGANGLIONOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANUS; ARTICLE; ASCENDING COLON; AUDITORY THRESHOLD; CECUM; CONGENIC STRAIN; CONTROLLED STUDY; DESCENDING COLON; DISEASE MODEL; DISEASE SEVERITY; DNA MODIFICATION; EDNRB GENE; FEMALE; GENE; GENE MUTATION; HEARING LOSS; HETEROZYGOSITY; HIRSCHSPRUNG DISEASE; HOMOZYGOSITY; INCIDENCE; LARGE INTESTINE; MALE; MEGACOLON; NEWBORN; NONHUMAN; PENETRANCE; PERCEPTION DEAFNESS; PERINATAL PERIOD; PIGMENT DISORDER; RAT; RAT STRAIN; SEX DIFFERENCE; STRIA VASCULARIS; SURVIVAL RATE; SURVIVAL TIME; SYMPTOM; WAARDENBURG SYNDROME; WAARDENBURG SYNDROME TYPE 4; WEIGHT GAIN; ANIMAL; FISCHER 344 RAT; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MUTATION;

RATTUS;

ANIMALS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEARING LOSS; HEARING LOSS, SENSORINEURAL; HIRSCHSPRUNG DISEASE; MICROSATELLITE REPEATS; MUTATION; RATS; RATS, INBRED F344; RECEPTOR, ENDOTHELIN B; WAARDENBURG'S SYNDROME;

EID: 80052526221     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024086     Document Type: Article

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