Pioglitazone inhibits TGFβ induced keratocyte transformation to myofibroblast and extracellular matrix production

Molecular Biology Reports

Volumn 38, Issue 7, 2011, Pages 4501-4508

  Pan, Hong Wei ^a,b   Xu, Jin Tang ^a   Chen, Jian Su ^a,b  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Cornea; Myofibroblast; Peroxisome proliferator activated receptors ; Pioglitazone; TGF ; Transformation

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; F ACTIN; FIBRONECTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; TRANSFORMING GROWTH FACTOR BETA1;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORNEA CELL; DRUG MECHANISM; EXTRACELLULAR MATRIX; FLUORESCENCE ANALYSIS; GENE EXPRESSION REGULATION; IMMUNOCYTOCHEMISTRY; MITOSIS INHIBITION; MYOFIBROBLAST; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RABBIT; WESTERN BLOTTING;

ACTIN CYTOSKELETON; ACTINS; ANIMALS; CELL DIFFERENTIATION; CELL LINE, TRANSFORMED; CELL PROLIFERATION; COLLAGEN TYPE I; CORNEAL KERATOCYTES; EXTRACELLULAR MATRIX; FIBRONECTINS; HUMANS; MYOFIBROBLASTS; PPAR GAMMA; RABBITS; RNA, MESSENGER; STRESS FIBERS; THIAZOLIDINEDIONES; TRANSFORMING GROWTH FACTOR BETA;

EID: 80052515078     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0581-5     Document Type: Article

References (42)

1. S Zafiriou SR Stanners S Saad TS Polhill P Poronnik CA Pollock 2005 Pioglitazone inhibits cell growth and reduces matrix production in human kidney fibroblasts J Am Soc Nephrol 16 638 645 15689403 10.1681/ASN.2004040278 1:CAS:528:DC%2BD2MXis12gu74%3D
2. L Yang CC Chan OS Kwon S Liu J McGhee SA Stimpson LZ Chen WW Harrington WT Symonds DC Rockey 2006 Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis Am J Physiol Gastrointest Liver Physiol 291 G902 G911 16798724 10.1152/ajpgi.00124.2006 1:CAS:528:DC%2BD28Xht1GnsLzJ
3. A Masamune K Kikuta M Satoh Y Sakai A Satoh T Shimosegawa 2002 Ligands of peroxisome proliferator-activated receptor-gamma block activation of pancreatic stellate cells J Biol Chem 277 141 147 11606585 10.1074/jbc.M107582200 1:CAS:528:DC%2BD38XjslCqsg%3D%3D
4. R Jaster P Lichte B Fitzner P Brock A Glass T Karopka L Gierl D Koczan HJ Thiesen G Sparmann J Emmrich S Liebe 2005 Peroxisome proliferator-activated receptor gamma overexpression inhibits pro-fibrogenic activities of immortalised rat pancreatic stellate cells J Cell Mol Med 9 670 682 16202214 10.1111/j.1582-4934.2005.tb00497.x 1:CAS:528:DC%2BD2sXlvFCksrs%3D
5. HA Burgess LE Daugherty TH Thatcher HF Lakatos DM Ray M Redonnet RP Phipps PJ Sime 2005 PPAR gamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis Am J Physiol Lung Cell Mol Physiol 288 L1146 L1153 15734787 10.1152/ajplung.00383.2004 1:CAS:528:DC%2BD2MXlsVylur8%3D
6. M Nakamoto Y Ohya T Shinzato R Mano M Yamazato A Sakima S Takishita 2008 Pioglitazone, a thiazolidinedione derivative, attenuates left ventricular hypertrophy and fibrosis in salt-sensitive hypertension Hypertens Res 31 353 361 18360056 10.1291/hypres.31.353 1:CAS:528:DC%2BD1cXmt1art7s%3D
7. H Pan J Chen J Xu M Chen R Ma 2009 Antifibrotic effect by activation of peroxisome proliferator-activated receptor-γ in corneal fibroblasts Mol Vis 15 2279 2286 19936025 1:CAS:528:DC%2BD1MXhsVKlt7bJ
8. D Xing JA Bonanno 2009 Effect of cAMP on TGF beta1-induced corneal keratocyte-myofibroblast transformation Invest Ophthalmol Vis Sci 50 626 633 18936144 10.1167/iovs.08-2444
9. JV Jester PA Barry-Lane HD Cavanagh WM Petroll 1996 Induction of alpha-smooth muscle actin expression and myofibroblast transformation in cultured corneal keratocytes Cornea 15 505 516 8862928 10.1097/00003226- 199609000-00011 1:STN:280:DyaK2s%2Fhs1aqsQ%3D%3D
10. JL Funderburgh ML Funderburgh MM Mann L Corpuz MR Roth 2001 Proteoglycan expression during transforming growth factor beta-induced keratocyte- myofibroblast transdifferentiation J Biol Chem 276 44173 44178 11555658 10.1074/jbc.M107596200 1:STN:280:DC%2BD3MnmslKmsA%3D%3D
11. JV Jester WM Petroll HD Cavanagh 1999 Corneal stromal wound healing in refractive surgery: the role of myofibroblasts Prog Retin Eye Res 18 311 356 10192516 10.1016/S1350-9462(98)00021-4 1:STN:280:DyaK1M3gs1Ogtg%3D%3D
12. MV Netto RR Mohan S Sinha A Sharma W Dupps SE Wilson 2006 Stromal haze, myofibroblasts, and surface irregularity after PRK Exp Eye Res 82 788 797 16303127 10.1016/j.exer.2005.09.021 1:CAS:528:DC%2BD28XhtFejsr4%3D
13. JV Jester J Huang PA Barry-Lane WW Kao WM Petroll HD Cavanagh 1999 Transforming growth factor (beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly Invest Ophthalmol Vis Sci 40 1959 1967 10440249 1:STN:280:DyaK1Mzms1ylsw%3D%3D
14. ME Fini 1999 Keratocyte and fibroblast phenotypes in the repairing cornea Prog Retin Eye Res 18 529 551 10217482 10.1016/S1350-9462(98)00033-0 1:CAS:528:DyaK1MXit1Wksbk%3D
15. JC He HEP Bazan 2008 Epidermal growth factor synergism with TGF-beta 1 via PI-3 kinase activity in corneal keratocyte differentiation Invest Ophthalmol Vis Sci 49 2936 2945 18579759 10.1167/iovs.07-0900
16. Q Garrett PT Khaw TD Blalock GS Schultz GR Grotendorst JT Daniels 2004 Involvement of CTGF in TGF-beta1-stimulation of myofibroblast differentiation and collagen matrix contraction in the presence of mechanical stress Invest Ophthalmol Vis Sci 45 1109 1116 15037576 10.1167/iovs.03-0660
17. JV Jester JY Huang WM Petroll HD Cavanagh 2002 TGF beta induced myofibroblast differentiation of rabbit keratocytes requires synergistic TGF beta, PDGF and integrin signaling Exp Eye Res 75 645 657 12470966 10.1006/exer.2002.2066 1:CAS:528:DC%2BD38XovFKksr4%3D
18. WJ Kim RR Mohan SE Wilson 1999 Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea Invest Ophthalmol Vis Sci 40 1364 1372 10359318 1:STN:280:DyaK1M3osFymsw%3D%3D
19. H Kaur SS Chaurasia V Agrawal C Suto SE Wilson 2009 Corneal myofibroblast viability: opposing effects of IL-1 and TGF beta1 Exp Eye Res 89 152 158 19285499 10.1016/j.exer.2009.03.001 1:CAS:528:DC%2BD1MXoslCmtbw%3D
20. SE Wilson SS Chaurasia FW Medeiros 2007 Apoptosis in the initiation, modulation and termination of the corneal wound healing response Exp Eye Res 85 305 311 17655845 10.1016/j.exer.2007.06.009 1:CAS:528:DC%2BD2sXpt1Sns7s%3D
21. D Xing JA Bonanno 2009 Hypoxia reduces TGFbeta1-induced corneal keratocyte myofibroblast transformation Mol Vis 15 1827 1834 19753310 1:CAS:528:DC%2BD1MXhtFyju7fK
22. H Kaur SS Chaurasia FW de Medeiros V Agrawal MQ Salomao N Singh BK Ambati SE Wilson 2009 Corneal stroma PDGF blockade and myofibroblast development Exp Eye Res 88 960 965 19133260 10.1016/j.exer.2008.12.006 1:CAS:528: DC%2BD1MXltVymsLs%3D
23. RM Evans 1988 The steroid and thyroid hormone receptor superfamily Science 240 889 895 3283939 10.1126/science.3283939 1:CAS:528:DyaL1cXktVSqsr4%3D
24. BP Kota THW Huang BD Roufogalis 2005 An overview on biological mechanisms of PPARs Pharmacol Res 51 85 94 15629253 10.1016/j.phrs.2004.07.012 1:CAS:528:DC%2BD2MXjvFGk
25. JP Berger TE Akiyama PT Meinke 2005 PPARs: therapeutic targets for metabolic disease Trends Pharmacol Sci 26 244 251 15860371 10.1016/j.tips.2005. 03.003 1:CAS:528:DC%2BD2MXjslKhsL8%3D
26. I Barroso M Gurnell VEF Crowley M Agostini JW Schwabe MA Soos GL Maslen TDM Williams H Lewis AJ Schafer VKK Chatterjee S O'Rahilly 1999 Dominant negative mutations in human PPAR gamma associated with severe insulin resistance, diabetes mellitus and hypertension Nature 402 880 883 10622252 1:CAS:528:DC%2BD3cXitFSltw%3D%3D
27. A Chawla Y Barak L Nagy D Liao P Tontonoz RM Evans 2001 PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation Nat Med 7 48 52 11135615 10.1038/83336 1:CAS:528:DC%2BD3MXmvV2nuw%3D%3D
28. JM Olefsky AR Saltiel 2000 PPAR gamma and the treatment of insulin resistance Trends Endocrinol Metab 11 362 368 11042466 10.1016/S1043-2760(00) 00306-4 1:CAS:528:DC%2BD3cXotVSrsbk%3D
29. B Staels JC Fruchart 2005 Therapeutic roles of peroxisome proliferator-activated receptor agonists Diabetes 54 2460 2470 16046315 10.2337/diabetes.54.8.2460 1:CAS:528:DC%2BD2MXnt1ynt7Y%3D
30. HX Ni NJ Yu XH Yang 2009 The study of ginsenoside on PPARgamma expression of mononuclear macrophage in type 2 diabetes Mol Biol Rep 37 2975 2979 19821054 10.1007/s11033-009-9864-0
31. S Saika O Yamanaka Y Okada T Miyamoto A Kitano KC Flanders Y Ohnishi Y Nakajima WWY Kao K Ikeda 2007 Effect of overexpression of ppar gamma on the healing process of corneal alkali burn in mice Am J Physiol Cell Physiol 293 C75 C86 17625041 10.1152/ajpcell.00332.2006 1:CAS:528:DC%2BD2sXosV2ntLc%3D
32. O Yamanaka K Miyazaki A Kitano S Saika Y Nakajima K Ikeda 2009 Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor gamma gene transfer in mice Invest Ophthalmol Vis Sci 50 187 193 18658087 10.1167/iovs.08-2282
33. BA Hocevar TL Brown PH Howe 1999 TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway EMBO J 18 1345 1356 10064600 10.1093/emboj/18.5.1345 1:CAS:528:DyaK1MXhvFOrsrk%3D
34. MR Stampfer P Yaswen M Alhadeff J Hosoda 1993 TGF beta induction of extracellular matrix associated proteins in normal and transformed human mammary epithelial cells in culture is independent of growth effects J Cell Physiol 155 210 221 8385676 10.1002/jcp.1041550127 1:CAS:528:DyaK3sXisVynuro%3D
35. Y Zhang P Huang T Jiang J Zhao N Zhang 2009 Role of aldose reductase in TGF-beta1-induced fibronectin synthesis in human mesangial cells Mol Biol Rep 37 2735 2742 19760097 10.1007/s11033-009-9811-0
36. XD Liu Y Sun SN Constantinescu E Karam RA Weinberg HF Lodish 1997 Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells Proc Natl Acad Sci USA 94 10669 10674 9380693 10.1073/pnas.94.20.10669 1:CAS:528:DyaK2sXmtleksL8%3D
37. X Wang W Sun J Bai L Ma Y Yu J Geng J Qi Z Shi S Fu 2009 Growth inhibition induced by transforming growth factor-beta1 in human oral squamous cell carcinoma Mol Biol Rep 36 861 869 18418730 10.1007/s11033-008-9256-x 1:CAS:528:DC%2BD1MXjvFejs7Y%3D
38. LM Carrington J Albon I Anderson C Kamma M Boulton 2006 Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors Invest Ophthalmol Vis Sci 47 1886 1894 16638995 10.1167/iovs.05-0635
39. X Tan H Dagher CA Hutton JE Bourke 2010 Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells Respir Res 11 21 20178607 10.1186/1465-9921-11-21
40. HA Burgess LE Daugherty TH Thatcher HF Lakatos DM Ray M Redonnet RP Phipps PJ Sime 2005 PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis Am J Physiol Lung Cell Mol Physiol 288 L1146 L1153 15734787 10.1152/ajplung.00383.2004 1:CAS:528:DC%2BD2MXlsVylur8%3D
41. S Han JD Ritzenthaler HN Rivera J Roman 2005 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1 Am J Physiol Lung Cell Mol Physiol 289 L419 L428 15908479 10.1152/ajplung.00002.2005 1:CAS:528:DC%2BD2MXhtVWksbbL
42. GY Zhang CG Yi X Li B Ma ZJ Li XL Chen SZ Guo WY Gao 2009 Troglitazone suppresses transforming growth factor-beta1-induced collagen type I expression in keloid fibroblasts Br J Dermatol 160 762 770 19120328 10.1111/j.1365-2133. 2008.08989.x 1:CAS:528:DC%2BD1MXlt1Gmtrs%3D