Improvement of anti-Burkholderia mouse monoclonal antibody from various phage-displayed single-chain antibody libraries

Journal of Immunological Methods

Volumn 372, Issue 1-2, 2011, Pages 146-161

  Kim, Ho San ^a   Lo, Shyh Ching ^a   Wear, Douglas J ^a   Stojadinovic, Alexander ^b   Weina, Peter J ^c   Izadjoo, Mina J ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Burkholderia bacteria; Chimeric MAb; Oligonucleotide directed mutagenesis; Phage displayed mouse scFv random and domain libraries; Random mutagenesis

Indexed keywords

AMINO ACID; BACTERIUM ANTIBODY; BURKHOLDERIA MALLEI ANTIBODY; BURKHOLDERIA PSEUDOMALLEI ANTIBODY; COMPLEMENTARITY DETERMINING REGION 3; IMMUNOGLOBULIN G1 ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; BURKHOLDERIA MALLEI; BURKHOLDERIA PSEUDOMALLEI; DNA SEQUENCE; DRUG PROTEIN BINDING; DRUG STRUCTURE; HEAVY CHAIN; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY EPITHELIUM; LIGHT CHAIN; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BURKHOLDERIA; BURKHOLDERIA INFECTIONS; CELL LINE; CLONING, MOLECULAR; COMPLEMENTARITY DETERMINING REGIONS; DNA, BACTERIAL; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; SEQUENCE ANALYSIS, DNA; SINGLE-CHAIN ANTIBODIES;

BURKHOLDERIA; BURKHOLDERIA MALLEI; BURKHOLDERIA PSEUDOMALLEI;

EID: 80052509616     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2011.07.009     Document Type: Article

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