Brain regional thyroid hormone status and Dio3: Where genetics, epigenetics and psychiatric vulnerability meet

Expert Review of Endocrinology and Metabolism

Volumn 6, Issue 5, 2011, Pages 649-652

  Sittig, Laura J ^a   Redei, Eva E ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

genetic imprinting; iodothyronine deiodinase type III; psychiatric disease; triiodothyronine

Indexed keywords

DEIODINASE TYPE III; LIOTHYRONINE; MEMBRANE PROTEIN; THYROID HORMONE; UNCLASSIFIED DRUG;

BRAIN LEVEL; DEPRESSION; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; EPIGENETICS; GENETICS; GENOTYPE; HORMONE ACTION; HUMAN; MENTAL DISEASE; META ANALYSIS (TOPIC); PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RISK FACTOR; THYROID HORMONE METABOLISM;

EID: 80052506380     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/eem.11.64     Document Type: Review

References (34)

1. Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr. Rev. 31(2), 139-170 (2010).
2. Guadaño-Ferraz A, Benavides-Piccione R, Venero C et al. Lack of thyroid hormone receptor a1 is associated with selective alterations in behavior and hippocampal circuits. Mol. Psychiatry 8(1), 30-38 (2003). (Pubitemid 36188571)
3. Stone JM,Greenough WT. Excess neonatal thyroxine: effects on learning in infant and adolescent rats. Dev. Psychobiol. 8(6), 479-488 (1975).
4. Wilcoxon JS, Kuo AG, Disterhoft JF, Redei EE. Behavioral deficits associated with fetal alcohol exposure are reversed by prenatal thyroid hormone treatment: a role for maternal thyroid hormone deficiency in FAE. Mol. Psychiatry 10(10), 961-971 (2005). (Pubitemid 41486489)
5. Henrichs J, Bongers-Schokking JJ, Schenk JJ et al. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. J. Clin. Endocrinol. Metab. 95(9), 4227-4234 (2010).
6. Gereben B, Zavacki AM, Ribich S et al. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling. Endocr. Rev. 29(7), 898-938 (2008).
7. Braun D, Kinne A, Bruer AU et al. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Glia 59(3), 463-471 (2011).
8. Sugiyama D, Kusuhara H, Taniguchi H et al. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. J. Biol. Chem. 278(44), 43489-43495 (2003). (Pubitemid 37345972)
9. Visser WE, Friesema EC, Jansen J, Visser TJ. Thyroid hormone transport in and out of cells. Trends Endocrinol. Metab. 19(2), 50-56 (2008). (Pubitemid 351317898)
10. Guadaño-Ferraz A, Obregn MJ, St Germain DL, Bernal J. The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proc. Natl Acad. Sci. USA 94(19), 10391-10396 (1997). (Pubitemid 27407052)
11. Friesema EC, Kuiper GG, Jansen J, Visser TJ, Kester MH. Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism. Mol. Endocrinol. 20(11), 2761-2772 (2006). (Pubitemid 44833533)
12. Gereben B, Zeöld A, Dentice M, Salvatore D, Bianco AC. Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences. Cell. Mol. Life Sci. 65(4), 570-590 (2008).
13. Hernandez A, Quignodon L, Martinez ME, Flamant F, St Germain DL. Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels. Endocrinology 151(11), 5550-5558 (2010).
14. Shukla PK, Sittig LJ, Andrus BM, Schaffer DJ, Batra KK, Redei EE. Prenatal thyroxine treatment disparately affects peripheral and amygdala thyroid hormone levels. Psychoneuroendocrinology 35(6), 791-797 (2010).
15. Sittig LJ, Herzing LB, Shukla PK, Redei EE. Parent-of-origin allelic contributions to deiodinase-3 expression elicit localized hyperthyroid milieu in the hippocampus. Mol. Psychiatry 16(8), 786-787 (2011).
16. Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D. The gene locus encoding iodothyronine deiodinase type 3 (Dio3) is imprinted in the fetus and expresses antisense transcripts. Endocrinology 143(11), 4483-4486 (2002). (Pubitemid 35239583)
17. Hernandez A, Fiering S, Martinez E, Galton VA, St Germain D. Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo. Curr. Biol. 12(14), 1221-1226 (2002).
18. Edwards CA, Mungall AJ, Matthews L et al. The evolution of the DLK1-DIO3 imprinted domain in mammals. PLoS Biol. 6(6), e135 (2008).
19. Sittig LJ, Shukla PK, Herzing LB, Redei EE. Strain-specific vulnerability to alcohol exposure in utero via hippocampal parent-of-origin expression of deiodinase-III. FASEB J. 25(7), 2313-2324 (2011).
20. Labialle S, Yang L, Ruan X et al. Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum. Mol. Genet. 17(1), 15-26 (2008).
21. Gregg C, Zhang J, Weissbourd B et al. High-resolution analysis of parent-of-origin allelic expression in the mouse brain. Science 329(5992), 643-648 (2010).
22. Chamberlain SJ, Lalande M, Neurodevelopmental disorders involving genomic imprinting at human chromosome 15q11-q13. Neurobiol. Dis. 39(1), 13-20 (2010).
23. Kong A, Steinthorsdottir V, Masson G et al. Parental origin of sequence variants associated with complex diseases. Nature 462(7275), 868-874 (2009).
24. Loosen PT. The TRH-induced TSH response in psychiatric patients: a possible neuroendocrine marker. Psychoneuroendocrinology 10(3), 237-260 (1985). (Pubitemid 16237734)
25. Bauer M, Goetz T, Glenn T, Whybrow PC et al. The thyroid-brain interaction in thyroid disorders and mood disorders. J. Neuroendocrinol. 20(10), 1101-1114 (2008).
26. Redei EE, Solberg LC, Kluczynski JM, Pare WP et al. Paradoxical hormonal and behavioral responses to hypothyroid and hyperthyroid states in the Wistar-Kyoto rat. Neuropsychopharmacology 24(6), 632-639 (2001). (Pubitemid 32452211)
27. dos Reis-Lunardelli EA, Ramirez MR, Castro CC et al. Effects of an acute treatment with L-thyroxine on memory, habituation, danger avoidance, and on Na+, K+ -ATPase activity in rat brain. Curr. Neurovasc. Res. 4(4), 259-267 (2007). (Pubitemid 350171826)
28. Shelton RC, Osuntokun O, Heinloth AN, Corya SA. Therapeutic options for treatment-resistant depression. CNS Drugs 24(2), 131-161 (2010).
29. Thase ME. Pharmacologic and therapeutic strategies in treatment-resistant depression. Augmentation strategies. CNS Spectr. 14(3 Suppl 4), 7-10 (2009).
30. Dixson L, Ridler K, Nichols TE et al. Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls. Psychoneuroendocrinology 36(6), 929-934 (2011).
31. Heuer H, Maier MK, Iden S et al. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 146(4), 1701-1706 (2005). (Pubitemid 40396877)
32. Kassem NA, Deane R, Segal MB, Preston JE. Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291(5), R1310-R1215 (2006).
33. Schreckenberger MF, Egle UT, Drecker S et al. Positron emission tomography reveals correlations between brain metabolism and mood changes in hyperthyroidism. J. Clin. Endocrinol. Metab. 91(12), 4786-4791 (2006). (Pubitemid 44917308)
34. Zhu DF, Wang ZX, Zhang DR et al. fMRI revealed neural substrate for reversible working memory dysfunction in subclinical hypothyroidism. Brain 129(Pt 11), 2923-2930 (2006).