Adiponectin gene variants and the risk of coronary artery disease in patients with type 2 diabetes

Molecular Biology Reports

Volumn 38, Issue 6, 2011, Pages 3703-3708

  Al Daghri, Nasser M ^a   Al Attas, Omar S ^a   Alokail, Majed S ^a   Alkharfy, Khalid M ^b   Hussain, Tajamul ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Adiponectin; Coronary artery disease; Polymorphisms; Type 2 diabetes

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADIPOQ GENE; ADULT; AGED; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIASTOLIC BLOOD PRESSURE; DYSLIPIDEMIA; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERTENSION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MARKER GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; POPULATION RESEARCH; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SAUDI ARABIA; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPONECTIN; AGED; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 80052442096     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0484-5     Document Type: Article

References (31)

1. Ferrarezi DA, Cheurfa N, Reis AF, Fumeron F, Velho G (2007) Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences. Arq Bras Endocrinol Metab 51:153-159.
2. Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB (2005) Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes. J Clin Endocrinol Metab 90:4542-4548. (Pubitemid 41159340)
3. Gable DR, Hurel SJ, Humphries SE (2006) Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease. Atherosclerosis 188:231-244. (Pubitemid 44301148)
4. Han SH, Quon MJ, Kim JA, Koh KK (2007) Adiponectin and cardiovascular disease: response to therapeutic interventions. J Am Coll Cardiol 49:531-538. (Pubitemid 46177440)
5. Kawano J, Arora R (2009) The role of adiponectin in obesity, diabetes, and cardiovascular disease. J Cardiometab Syndr 4:44-49.
6. Maeda K, Okubo K, Shimomura I, Funahashi T, Matsuzawa Y, Matsubara K (1996) cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem Biophys Res Commun 221: 286-289. (Pubitemid 26136463)
7. Mori Y, Otabe S, Dina C et al (2002) Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 51:1247-1255. (Pubitemid 34438376)
8. Vionnet N, Hani EH, Dupont S et al (2000) Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am J Hum Genet 67:1470-1480.
9. Francke S, Manraj M, Lacquemant C et al (2001) A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum Mol Genet 10:2751- 2765. (Pubitemid 34026457)
10. Kissebah AH, Sonnenberg GE, Myklebust J (2000) Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci USA 97:14478-14483. (Pubitemid 32016601)
11. Comuzzie AG, Funahashi T, Sonnenberg G et al (2001) The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J Clin Endocrinol Metab 86:4321-4325. (Pubitemid 32848553)
12. Heid IM, Wagner SA, Gohlke H et al (2006) Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1, 727 healthy Caucasians. Diabetes 55:375-384. (Pubitemid 43343266)
13. Menzaghi C, Trischitta V, Doria A (2007) Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes 56:1198-1209. (Pubitemid 46715598)
14. Bacci S, Menzaghi C, Ercolino T (2004) The +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with coronary artery disease in type 2 diabetic patients. Diabetes Care 27:2015-2020. (Pubitemid 38989248)
15. Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, Doria A, Hu FB (2005) The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes 54:1607-1610. (Pubitemid 40586698)
16. Lacquemant C, Froguel P, Lobbens S, Izzo P, Dina C, Ruiz J (2004) The adiponectin gene SNP +45 is associated with coronary artery disease in Type 2 (non-insulin-dependent) diabetes mellitus. Diabet Med 21:776-781. (Pubitemid 38916225)
17. Kim SH, Kang ES, Hur KY et al (2008) Adiponectin gene polymorphism 45T>G is associated with carotid artery plaques in patients with type 2 diabetes mellitus. Metabolism 57:274-279.
18. Qi L, Doria A, Manson JE, Meigs JB, Hunter D, Mantzoros CS, Hu FB (2006) Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes 55:1512-1516. (Pubitemid 44195395)
19. Filippi E, Sentinelli F, Romeo S et al (2005) The adiponectin gene SNP + 276G>T associates with early-onset coronary artery disease and with lower levels of adiponectin in younger coronary artery disease patients. J Mol Med 83:711-719. (Pubitemid 41225113)
20. Yang WS, Chuang LM (2006) Human genetics of adiponectin in the metabolic syndrome. J Mol Med 84:112-121.
21. Li LL, Kang XL, Ran XJ et al (2007) Associations between 45T/G polymorphismof the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol 34:1287-1290.
22. Pischon T, Pai JK, Manson JE, Hu FB, Rexrode KM, Hunter D, Rimm EB (2007) Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women. Obesity (Silver Spring) 15:2051-2060. (Pubitemid 47402237)
23. Lee YY, Lee NS, Cho YM et al (2005) Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabet Med 2005 22:569-575. (Pubitemid 40593132)
24. Hoefle G, Muendlein A, Saely CH (2007) The -11377 C>G promoter variant of the adiponectin gene, prevalence of coronary atherosclerosis, and incidence of vascular events in men. Thromb Haemost 97:451-457. (Pubitemid 46437808)
25. Mackevics V, Heid IM, Wagner SA et al (2006) The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians. Eur J Hum Genet 14:349-356.
26. Yang WS, Tsou PL, Lee WJ et al (2003) Allele-specific differential expression of a common adiponectin gene polymorphism related to obesity. J Mol Med 81:428-434.
27. Takahashi M, Arita Y, Yamagata K et al (2000) Genomic structure and mutations in adipose-specific gene, adiponectin. Int J Obes Relat Metab Disord 24:861-868. (Pubitemid 30449921)
28. Vasseur F, Helbecque N, Dina C et al (2002) Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11:2607-2614. (Pubitemid 35174690)
29. Lindsay RS, Funahashi T, Krakoff J et al (2003) Genome-wide linkage analysis of serum adiponectin in the Pima Indian population. Diabetes 52:2419-2425. (Pubitemid 37059515)
30. Conne B, Stutz A, Vassalli JD (2000) The 30 untranslated region of messenger RNA: a molecular 'hotspot' for pathology? Nat Med 6:637-641. (Pubitemid 30398786)
31. Cartegni L, Chew SL, Krainer AR (2002) Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet 3:285-298. (Pubitemid 34279797)