A methyl-deviator epigenotype of estrogen receptor-positive breast carcinoma is associated with malignant biology

American Journal of Pathology

Volumn 179, Issue 1, 2011, Pages 55-65

  Killian, J Keith ^a   Bilke, Sven ^a   Davis, Sean ^a   Walker, Robert L ^a   Jaeger, Erich ^b   Killian, M Scott ^c   Waterfall, Joshua J ^a   Bibikova, Marina ^b   Fan, Jian Bing ^b   Smith Jr , William I ^d   Meltzer, Paul S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ILLUMINA INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SUBURBAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; KI 67 ANTIGEN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GENETICS; CANCER RISK; CANCER SURVIVAL; COMPARATIVE STUDY; DISEASE ASSOCIATION; DNA METHYLATION; FEMALE; GENE TARGETING; HIGH RISK POPULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INVASIVE CARCINOMA; KAPLAN MEIER METHOD; LARGE SCALE PRODUCTION; MAJOR CLINICAL STUDY; MALE; PARENCHYMA; PHENOTYPE; PRIORITY JOURNAL;

AGED; BREAST; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CARCINOMA, MEDULLARY; DNA METHYLATION; EPIGENOMICS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPHENOTYPING; LONGITUDINAL STUDIES; LYMPHOCYTES; MESODERM; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; RECEPTORS, ESTROGEN; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 80052428035     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.03.022     Document Type: Article

References (68)

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28. E.R. Fisher, J.P. Kenny, R. Sass, N.V. Dimitrov, R.H. Siderits, and B. Fisher Medullary cancer of the breast revisited Breast Cancer Res Treat 16 1990 215 229
29. D.L. Page Special types of invasive breast cancer, with clinical implications Am J Surg Pathol 27 2003 832 835
30. E.R. Fisher, J.P. Costantino, M.E. Leon, H. Bandos, A.S. Palekar, B. Fisher, and N. Wolmark Pathobiology of small invasive breast cancers without metastases (T1a/b. N0, M0): National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-21 Cancer 110 2007 1929 1936
31. H.M. Muller, H. Fiegl, A. Widschwendter, and M. Widschwendter Prognostic DNA methylation marker in serum of cancer patients Ann NY Acad Sci 1022 2004 44 49
32. S. Li, M. Rong, and B. Iacopetta DNA hypermethylation in breast cancer and its association with clinicopathological features Cancer Lett 237 2006 272 280
33. B. Gusterson Do "basal-like" breast cancers really exist? Nat Rev Cancer 9 2009 128 134
34. A.E. Teschendorff, A. Miremadi, S.E. Pinder, I.O. Ellis, and C. Caldas An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer Genome Biol 8 2007 R157
35. T. Sorlie, C.M. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M.B. Eisen, M. van de Rijn, S.S. Jeffrey, T. Thorsen, H. Quist, J.C. Matese, P.O. Brown, D. Botstein, P. Eystein Lonning, and A.L. Borresen-Dale Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc Natl Acad Sci U S A 98 2001 10869 10874 (Pubitemid 32878711)
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38. K. Holm, C. Hegardt, J. Staaf, J. Vallon-Christersson, G. Jönsson, H. Olsson, A. Borg, and M. Ringnér Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns Breast Cancer Res 12 2010 R36
39. N. Bloushtain-Qimron, J. Yao, E.L. Snyder, M. Shipitsin, L.L. Campbell, S.A. Mani, M. Hu, H. Chen, V. Ustyansky, J.E. Antosiewicz, P. Argani, M.K. Halushka, J.A. Thomson, P. Pharoah, A. Porgador, S. Sukumar, R. Parsons, A.L. Richardson, M.R. Stampfer, R.S. Gelman, T. Nikolskaya, Y. Nikolsky, and K. Polyak Cell type-specific DNA methylation patterns in the human breast Proc Natl Acad Sci U S A 105 2008 14076 14081
40. J.W. Martens, A.L. Margossian, M. Schmitt, J. Foekens, and N. Harbeck DNA methylation as a biomarker in breast cancer Future Oncol 5 2009 1245 1256
41. M. Widschwendter, K.D. Siegmund, H.M. Muller, H. Fiegl, C. Marth, E. Muller-Holzner, P.A. Jones, and P.W. Laird Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen Cancer Res 64 2004 3807 3813 (Pubitemid 38697289)
42. J.K. Killian, S. Bilke, S. Davis, R.L. Walker, M.S. Killian, E.B. Jaeger, Y. Chen, J. Hipp, S. Pittaluga, M. Raffeld, R. Cornelison, W.I. Smith Jr, M. Bibikova, J.B. Fan, M.R. Emmert-Buck, E.S. Jaffe, and P.S. Meltzer Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome Cancer Res 69 2009 758 764
43. J.K. Killian, R.L. Walker, M. Suuriniemi, L. Jones, S. Scurci, P. Singh, R. Cornelison, S. Harmon, N. Boisvert, J. Zhu, Y. Wang, S. Bilke, S. Davis, G. Giaccone, W.I. Smith Jr, and P.S. Meltzer Archival fine-needle aspiration cytopathology (FNAC) samples: untapped resource for clinical molecular profiling J Mol Diagn 12 2010 739 745
44. S.R. Wellings A hypothesis of the origin of human breast cancer from the terminal ductal lobular unit Pathol Res Pract 166 1980 515 535 (Pubitemid 10064978)
45. S.R. Wellings, and H.M. Jensen On the origin and progression of ductal carcinoma in the human breast J Natl Cancer Inst 50 1973 1111 1118
46. B.A. Gusterson, D.T. Ross, V.J. Heath, and T. Stein Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer Breast Cancer Res 7 2005 143 148 (Pubitemid 40872776)
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48. H.M. Byun, K.D. Siegmund, F. Pan, D.J. Weisenberger, G. Kanel, P.W. Laird, and A.S. Yang Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns Hum Mol Genet 18 2009 4808 4817
49. S. Paik, S. Shak, G. Tang, C. Kim, J. Baker, M. Cronin, F.L. Baehner, M.G. Walker, D. Watson, T. Park, W. Hiller, E.R. Fisher, D.L. Wickerham, J. Bryant, and N. Wolmark A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer N Engl J Med 351 2004 2817 2826 (Pubitemid 40051905)
50. F.A. Tavassoli, P. Devilee International Agency for Research on Cancer, World Health Organization Pathology and Genetics of Tumours of the Breast and Female Genital Organs 2003 IAPS Press Lyon 432
51. E.R. Fisher, R. Sass, and B. Fisher Pathologic findings from the National Surgical Adjuvant Project for Breast Cancers (protocol no. 4), X: discriminants for tenth year treatment failure Cancer 53 Suppl 1984 712 723 (Pubitemid 14190897)
52. R.L. Ridolfi, P.P. Rosen, A. Port, D. Kinne, and V. Mike Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up Cancer 40 1977 1365 1385 (Pubitemid 8221704)
53. E.A. Rakha, M. Aleskandarany, M.E. El-Sayed, R.W. Blamey, C.W. Elston, I.O. Ellis, and A.H. Lee The prognostic significance of inflammation and medullary histological type in invasive carcinoma of the breast Eur J Cancer 45 2009 1780 1787
54. C.W. Elston, and I.O. Ellis Pathological prognostic factors in breast cancer, I: the value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 1991 403 410
55. P. Gaglia, A. Bernardi, T. Venesio, B. Caldarola, D. Lauro, A.P. Cappa, P. Calderini, and D.S. Liscia Cell proliferation of breast cancer evaluated by anti-BrdU and anti-Ki-67 antibodies: its prognostic value on short-term recurrences Eur J Cancer 29A 1993 1509 1513 (Pubitemid 23251787)
56. J.Y. Pierga, A. Leroyer, P. Viehl, V. Mosseri, S. Chevillard, and H. Magdelenat Long term prognostic value of growth fraction determination by Ki-67 immunostaining in primary operable breast cancer Breast Cancer Res Treat 37 1996 57 64 (Pubitemid 26028246)
57. T.O. Nielsen, F.D. Hsu, K. Jensen, M. Cheang, G. Karaca, Z. Hu, T. Hernandez-Boussard, C. Livasy, D. Cowan, L. Dressler, L.A. Akslen, J. Ragaz, A.M. Gown, C.B. Gilks, M. van de Rijn, and C.M. Perou Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma Clin Cancer Res 10 2004 5367 5374 (Pubitemid 39100473)
58. M. Bibikova, and J.B. Fan GoldenGate assay for DNA methylation profiling Methods Mol Biol 507 2009 149 163
59. M. Bibikova, Z. Lin, L. Zhou, E. Chudin, E.W. Garcia, B. Wu, D. Doucet, N.J. Thomas, Y. Wang, E. Vollmer, T. Goldmann, C. Seifart, W. Jiang, D.L. Barker, M.S. Chee, J. Floros, and J.B. Fan High-throughput DNA methylation profiling using universal bead arrays Genome Res 16 2006 383 393 (Pubitemid 43327509)
60. T.I. Lee, R.G. Jenner, L.A. Boyer, M.G. Guenther, S.S. Levine, R.M. Kumar, B. Chevalier, S.E. Johnstone, M.F. Cole, K. Isono, H. Koseki, T. Fuchikami, K. Abe, H.L. Murray, J.P. Zucker, B. Yuan, G.W. Bell, E. Herbolsheimer, N.M. Hannett, K. Sun, D.T. Odom, A.P. Otte, T.L. Volkert, D.P. Bartel, D.A. Melton, D.K. Gifford, R. Jaenisch, and R.A. Young Control of developmental regulators by Polycomb in human embryonic stem cells Cell 125 2006 301 313 (Pubitemid 44313811)
61. C.Y. Lin, V.B. Vega, J.S. Thomsen, T. Zhang, S.L. Kong, M. Xie, K.P. Chiu, L. Lipovich, D.H. Barnett, F. Stossi, A. Yeo, J. George, V.A. Kuznetsov, Y.K. Lee, T.H. Charn, N. Palanisamy, L.D. Miller, E. Cheung, B.S. Katzenellenbogen, Y. Ruan, G. Bourque, C.L. Wei, and E.T. Liu Whole-genome cartography of estrogen receptor alpha binding sites PLoS Genet 3 2007 e87
62. E.R. Fisher, J.P. Kenny, R. Sass, N.V. Dimitrov, R.H. Siderits, and B. Fisher Medullary cancer of the breast revisited Breast Cancer Res Treat 16 1990 215 229
63. D.L. Page Special types of invasive breast cancer, with clinical implications Am J Surg Pathol 27 2003 832 835 (Pubitemid 36617522)
64. E.R. Fisher, J.P. Costantino, M.E. Leon, H. Bandos, A.S. Palekar, B. Fisher, and N. Wolmark Pathobiology of small invasive breast cancers without metastases (T1a/b. N0, M0): National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-21 Cancer 110 2007 1929 1936 (Pubitemid 350036850)
65. H.M. Muller, H. Fiegl, A. Widschwendter, and M. Widschwendter Prognostic DNA methylation marker in serum of cancer patients Ann NY Acad Sci 1022 2004 44 49 (Pubitemid 38951580)
66. S. Li, M. Rong, and B. Iacopetta DNA hypermethylation in breast cancer and its association with clinicopathological features Cancer Lett 237 2006 272 280 (Pubitemid 43792523)
67. B. Gusterson Do "basal-like" breast cancers really exist? Nat Rev Cancer 9 2009 128 134
68. A.E. Teschendorff, A. Miremadi, S.E. Pinder, I.O. Ellis, and C. Caldas An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer Genome Biol 8 2007 R157