메뉴 건너뛰기




Volumn 71, Issue 2, 2011, Pages 168-177

Interplay of salicylaldehyde, lysine, and M 2+ ions on α-synuclein aggregation: Cancellation of aggregation effects and determination of salicylaldehyde neurotoxicity

Author keywords

Synuclein; Copper(II); L Lysine; Protein aggregation; Salicylaldehyde; Zinc(II)

Indexed keywords

ALPHA SYNUCLEIN; COPPER ION; LYSINE; MANGANESE; SALICYLALDEHYDE; SCAVENGER; ZINC ION;

EID: 80052385533     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2011.07.003     Document Type: Article
Times cited : (10)

References (49)
  • 1
    • 14844298766 scopus 로고    scopus 로고
    • Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula)
    • Aalto-Korte K., Valimaa J., Henriks-Eckerman M.L., Jolanki R. Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula). Contact Dermatitis 2005, 52(2):93-95.
    • (2005) Contact Dermatitis , vol.52 , Issue.2 , pp. 93-95
    • Aalto-Korte, K.1    Valimaa, J.2    Henriks-Eckerman, M.L.3    Jolanki, R.4
  • 3
    • 67650033008 scopus 로고    scopus 로고
    • Characteristics of compounds that cross the blood-brain barrier
    • Banks W.A. Characteristics of compounds that cross the blood-brain barrier. BMC Neurol. 2009, 9.
    • (2009) BMC Neurol. , vol.9
    • Banks, W.A.1
  • 4
    • 33747769942 scopus 로고    scopus 로고
    • A-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
    • Beyer K. A-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers. Acta Neuropathol. 2006, 112(1):237-251.
    • (2006) Acta Neuropathol. , vol.112 , Issue.1 , pp. 237-251
    • Beyer, K.1
  • 6
    • 33646451063 scopus 로고    scopus 로고
    • Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate [alpha]-synuclein fibrilization
    • Bosco D.A., Fowler D.M., Zhang Q., Nieva J., Powers E.T., Wentworth P., Lerner R.A., Kelly J.W. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate [alpha]-synuclein fibrilization. Nat. Chem. Biol. 2006, 2(5):249-253.
    • (2006) Nat. Chem. Biol. , vol.2 , Issue.5 , pp. 249-253
    • Bosco, D.A.1    Fowler, D.M.2    Zhang, Q.3    Nieva, J.4    Powers, E.T.5    Wentworth, P.6    Lerner, R.A.7    Kelly, J.W.8
  • 7
    • 0033566854 scopus 로고    scopus 로고
    • Quantitation of 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde, the monoamine oxidase metabolites of dopamine and noradrenaline, in human tissues by microcolumn high-performance liquid chromatography
    • Burke W.J., Chung H.D., Li S.W. Quantitation of 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde, the monoamine oxidase metabolites of dopamine and noradrenaline, in human tissues by microcolumn high-performance liquid chromatography. Anal. Biochem. 1999, 273(1):111-116.
    • (1999) Anal. Biochem. , vol.273 , Issue.1 , pp. 111-116
    • Burke, W.J.1    Chung, H.D.2    Li, S.W.3
  • 9
    • 0141638380 scopus 로고    scopus 로고
    • 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis
    • Burke W.J., Li S.W., Williams E.A., Nonneman R., Zahm D.S. 3,4-Dihydroxyphenylacetaldehyde is the toxic dopamine metabolite in vivo: implications for Parkinson's disease pathogenesis. Brain Res. 2003, 989(2):205-213.
    • (2003) Brain Res. , vol.989 , Issue.2 , pp. 205-213
    • Burke, W.J.1    Li, S.W.2    Williams, E.A.3    Nonneman, R.4    Zahm, D.S.5
  • 10
    • 0037386086 scopus 로고    scopus 로고
    • The metallobiology of Alzheimer's disease
    • Bush A.I. The metallobiology of Alzheimer's disease. Trends Neurosci. 2003, 26(4):207-214.
    • (2003) Trends Neurosci. , vol.26 , Issue.4 , pp. 207-214
    • Bush, A.I.1
  • 11
    • 15744402739 scopus 로고    scopus 로고
    • Metal-catalyzed oxidation of A-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments
    • Cole N.B., Murphy D.D., Lebowitz J., Di Noto L., Levine R.L., Nussbaum R.L. Metal-catalyzed oxidation of A-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments. J. Biol. Chem. 2005, 280(10):9678-9690.
    • (2005) J. Biol. Chem. , vol.280 , Issue.10 , pp. 9678-9690
    • Cole, N.B.1    Murphy, D.D.2    Lebowitz, J.3    Di Noto, L.4    Levine, R.L.5    Nussbaum, R.L.6
  • 12
    • 0032540327 scopus 로고    scopus 로고
    • Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes
    • Davidson W.S., Jonas A., Clayton D.F., George J.M. Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J. Biol. Chem. 1998, 273(16):9443-9449.
    • (1998) J. Biol. Chem. , vol.273 , Issue.16 , pp. 9443-9449
    • Davidson, W.S.1    Jonas, A.2    Clayton, D.F.3    George, J.M.4
  • 14
    • 1642439277 scopus 로고    scopus 로고
    • Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of guam determined by high-resolution ICP-MS
    • Gellein K., Garruto R., Syversen T., Sjøbakk T., Flaten T. Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and parkinsonism-dementia complex of guam determined by high-resolution ICP-MS. Biol. Trace Elem. Res. 2003, 96(1):39-60.
    • (2003) Biol. Trace Elem. Res. , vol.96 , Issue.1 , pp. 39-60
    • Gellein, K.1    Garruto, R.2    Syversen, T.3    Sjøbakk, T.4    Flaten, T.5
  • 15
    • 79955829789 scopus 로고    scopus 로고
    • A tutorial and mini-review of the ICP-MS technique for determinations of transition metal ion and main group element concentration in the neurodegenerative and brain sciences
    • Ha Y., Tsay O., Churchill D. A tutorial and mini-review of the ICP-MS technique for determinations of transition metal ion and main group element concentration in the neurodegenerative and brain sciences. Monatshefte für Chemie/Chem. Monthly 2011, 142(4):385-398.
    • (2011) Monatshefte für Chemie/Chem. Monthly , vol.142 , Issue.4 , pp. 385-398
    • Ha, Y.1    Tsay, O.2    Churchill, D.3
  • 16
    • 39749097762 scopus 로고    scopus 로고
    • Salicylaldehyde is a characteristic aroma component of buckwheat groats
    • Janeš D., Kreft S. Salicylaldehyde is a characteristic aroma component of buckwheat groats. Food Chem. 2007, 109:293-298.
    • (2007) Food Chem. , vol.109 , pp. 293-298
    • Janeš, D.1    Kreft, S.2
  • 17
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Jeffrey D.R. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann. Neurol. 2009, 65(S1):S3-S9.
    • (2009) Ann. Neurol. , vol.65 , Issue.S1
    • Jeffrey, D.R.1
  • 18
    • 53349178146 scopus 로고    scopus 로고
    • Acrolein, the toxic endogenous aldehyde, induces neurofilament-l aggregation
    • Jeong M.S., Kang J.H. Acrolein, the toxic endogenous aldehyde, induces neurofilament-l aggregation. BMB Rep. 2008, 41(9):635-639.
    • (2008) BMB Rep. , vol.41 , Issue.9 , pp. 635-639
    • Jeong, M.S.1    Kang, J.H.2
  • 19
    • 67649949078 scopus 로고    scopus 로고
    • Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate
    • Jinsmaa Y., Florang V.R., Rees J.N., Anderson D.G., Strack S., Doorn J.A. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chem. Res. Toxicol. 2009, 22(5):835-841.
    • (2009) Chem. Res. Toxicol. , vol.22 , Issue.5 , pp. 835-841
    • Jinsmaa, Y.1    Florang, V.R.2    Rees, J.N.3    Anderson, D.G.4    Strack, S.5    Doorn, J.A.6
  • 20
    • 64549135841 scopus 로고    scopus 로고
    • Highly selective fluorescence detection of Cu2+ in water by chiral dimeric Zn2+ complexes through direct displacement
    • Khatua S., Choi S.H., Lee J., Huh J.O., Do Y., Churchill D.G. Highly selective fluorescence detection of Cu2+ in water by chiral dimeric Zn2+ complexes through direct displacement. Inorg. Chem. 2009, 48(5):1799.
    • (2009) Inorg. Chem. , vol.48 , Issue.5 , pp. 1799
    • Khatua, S.1    Choi, S.H.2    Lee, J.3    Huh, J.O.4    Do, Y.5    Churchill, D.G.6
  • 21
    • 64349112140 scopus 로고    scopus 로고
    • Aqueous fluorometric and colorimetric sensing of phosphate ions by a fluorescent dinuclear zinc complex
    • Khatua S., Choi S.H., Lee J., Kim K., Do Y., Churchill D.G. Aqueous fluorometric and colorimetric sensing of phosphate ions by a fluorescent dinuclear zinc complex. Inorg. Chem. 2009, 48(7):2993-2999.
    • (2009) Inorg. Chem. , vol.48 , Issue.7 , pp. 2993-2999
    • Khatua, S.1    Choi, S.H.2    Lee, J.3    Kim, K.4    Do, Y.5    Churchill, D.G.6
  • 22
    • 0036754381 scopus 로고    scopus 로고
    • Effects of aminoguanidine Schiff's base on biomarkers of the oxidative stress, 4-hydroxy-2-nonenal and conjugated dienes, in the model diabetes mellitus
    • Korytar P., Molnarova M., Sivonova M., Zitnanova I., Ulicna O., Liptakova A., Carsky J., Durackova Z. Effects of aminoguanidine Schiff's base on biomarkers of the oxidative stress, 4-hydroxy-2-nonenal and conjugated dienes, in the model diabetes mellitus. Gen. Physiol. Biophys. 2002, 21(3):337-344.
    • (2002) Gen. Physiol. Biophys. , vol.21 , Issue.3 , pp. 337-344
    • Korytar, P.1    Molnarova, M.2    Sivonova, M.3    Zitnanova, I.4    Ulicna, O.5    Liptakova, A.6    Carsky, J.7    Durackova, Z.8
  • 23
    • 34249818762 scopus 로고    scopus 로고
    • Influence of salicylaldehyde and methyl salicylate on post-landing behaviour of Frankliniella occidentalis Pergande
    • Koschier E.H., Hoffmann D., Riefler J. Influence of salicylaldehyde and methyl salicylate on post-landing behaviour of Frankliniella occidentalis Pergande. J. Appl. Entomol. 2007, 131(5):362-367.
    • (2007) J. Appl. Entomol. , vol.131 , Issue.5 , pp. 362-367
    • Koschier, E.H.1    Hoffmann, D.2    Riefler, J.3
  • 24
    • 33748289433 scopus 로고    scopus 로고
    • Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide
    • Kowalik-Jankowska T., Rajewska A., Jankowska E., Wisniewska K., Grzonka Z. Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide. J. Inorg. Biochem. 2006, 100(10):1623-1631.
    • (2006) J. Inorg. Biochem. , vol.100 , Issue.10 , pp. 1623-1631
    • Kowalik-Jankowska, T.1    Rajewska, A.2    Jankowska, E.3    Wisniewska, K.4    Grzonka, Z.5
  • 25
    • 28444447471 scopus 로고    scopus 로고
    • Coordination abilities of N-terminal fragments of alpha-synuclein towards copper(II) ions: a combined potentiometric and spectroscopic study
    • Kowalik-Jankowska T., Rajewska A., Wisniewska K., Grzonka Z., Jezierska J. Coordination abilities of N-terminal fragments of alpha-synuclein towards copper(II) ions: a combined potentiometric and spectroscopic study. J. Inorg. Biochem. 2005, 99(12):2282-2291.
    • (2005) J. Inorg. Biochem. , vol.99 , Issue.12 , pp. 2282-2291
    • Kowalik-Jankowska, T.1    Rajewska, A.2    Wisniewska, K.3    Grzonka, Z.4    Jezierska, J.5
  • 26
    • 70349211883 scopus 로고    scopus 로고
    • Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)
    • Kozlowski H., Janicka-Klos A., Brasun J., Gaggelli E., Valensin D., Valensin G. Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation). Coord. Chem. Rev. 2009, 253(21-22):2665-2685.
    • (2009) Coord. Chem. Rev. , vol.253 , Issue.21-22 , pp. 2665-2685
    • Kozlowski, H.1    Janicka-Klos, A.2    Brasun, J.3    Gaggelli, E.4    Valensin, D.5    Valensin, G.6
  • 27
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 2001, 46(1-3):3-26.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , Issue.1-3 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 29
    • 77149121411 scopus 로고    scopus 로고
    • Effect of dioxygen on copper(II) binding to [alpha]-synuclein
    • Lucas H.R., Lee J.C. Effect of dioxygen on copper(II) binding to [alpha]-synuclein. J. Inorg. Biochem. 2009, 104(3):245-249.
    • (2009) J. Inorg. Biochem. , vol.104 , Issue.3 , pp. 245-249
    • Lucas, H.R.1    Lee, J.C.2
  • 30
    • 0034708767 scopus 로고    scopus 로고
    • Membrane association and protein conformation of α-synuclein in intact neurons
    • McLean P.J., Kawamata H., Ribich S., Hyman B.T. Membrane association and protein conformation of α-synuclein in intact neurons. J. Biol. Chem. 2000, 275(12):8812-8816.
    • (2000) J. Biol. Chem. , vol.275 , Issue.12 , pp. 8812-8816
    • McLean, P.J.1    Kawamata, H.2    Ribich, S.3    Hyman, B.T.4
  • 32
    • 0032697984 scopus 로고    scopus 로고
    • Biological effects of aminoguanidine: an update
    • Nilsson B.O. Biological effects of aminoguanidine: an update. Inflamm. Res. 1999, 48(10):509-515.
    • (1999) Inflamm. Res. , vol.48 , Issue.10 , pp. 509-515
    • Nilsson, B.O.1
  • 33
    • 0029035114 scopus 로고
    • Transport of small molecules through the blood-brain-barrier-biology and methodology
    • Pardridge W.M. Transport of small molecules through the blood-brain-barrier-biology and methodology. Adv. Drug Deliv. Rev. 1995, 15(1-3):5-36.
    • (1995) Adv. Drug Deliv. Rev. , vol.15 , Issue.1-3 , pp. 5-36
    • Pardridge, W.M.1
  • 34
    • 0031959341 scopus 로고    scopus 로고
    • CNS drug design based on principles of blood-brain barrier transport
    • Pardridge W.M. CNS drug design based on principles of blood-brain barrier transport. J. Neurochem. 1998, 70(5):1781-1792.
    • (1998) J. Neurochem. , vol.70 , Issue.5 , pp. 1781-1792
    • Pardridge, W.M.1
  • 35
    • 77049084488 scopus 로고    scopus 로고
    • Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes
    • Peng Y., Wang C.S., Xu H.H., Liu Y.N., Zhou F.M. Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes. J. Inorg. Biochem. 2010, 104(4):365-370.
    • (2010) J. Inorg. Biochem. , vol.104 , Issue.4 , pp. 365-370
    • Peng, Y.1    Wang, C.S.2    Xu, H.H.3    Liu, Y.N.4    Zhou, F.M.5
  • 37
    • 34247130917 scopus 로고    scopus 로고
    • Effect of 4-hydroxy-2-nonenal modification on A-synuclein aggregation
    • Qin Z., Hu D., Han S., Reaney S.H., Monte D.A.D., Fink A.L. Effect of 4-hydroxy-2-nonenal modification on A-synuclein aggregation. J. Biol. Chem. 2007, 282(8):5862-5870.
    • (2007) J. Biol. Chem. , vol.282 , Issue.8 , pp. 5862-5870
    • Qin, Z.1    Hu, D.2    Han, S.3    Reaney, S.H.4    Monte, D.A.D.5    Fink, A.L.6
  • 38
    • 34547753332 scopus 로고    scopus 로고
    • Antimicrobial synergism and antagonism of salicylaldehyde in Filipendula vulgaris essential oil
    • Radulovic N., Misic M., Aleksic J., Dokovi D., Palic R., Stojanovic G. Antimicrobial synergism and antagonism of salicylaldehyde in Filipendula vulgaris essential oil. Fitoterapia 2007, 78(7-8):565-570.
    • (2007) Fitoterapia , vol.78 , Issue.7-8 , pp. 565-570
    • Radulovic, N.1    Misic, M.2    Aleksic, J.3    Dokovi, D.4    Palic, R.5    Stojanovic, G.6
  • 39
    • 67651005418 scopus 로고    scopus 로고
    • Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol
    • Rees J.N., Florang V.R., Eckert L.L., Doorn J.A. Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol. Chem. Res. Toxicol. 2009, 22:1256-1263.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 1256-1263
    • Rees, J.N.1    Florang, V.R.2    Eckert, L.L.3    Doorn, J.A.4
  • 40
    • 0030981036 scopus 로고    scopus 로고
    • Predicting modes of toxic action from chemical structure: acute toxicity in the fathead minnow (Pimephales promelas)
    • Russom C.L., Bradbury S.P., Broderius S.J., Hammermeister D.E., Drummond R.A. Predicting modes of toxic action from chemical structure: acute toxicity in the fathead minnow (Pimephales promelas). Environ. Toxicol. Chem. 1997, 16(5):948-967.
    • (1997) Environ. Toxicol. Chem. , vol.16 , Issue.5 , pp. 948-967
    • Russom, C.L.1    Bradbury, S.P.2    Broderius, S.J.3    Hammermeister, D.E.4    Drummond, R.A.5
  • 41
    • 62149135335 scopus 로고    scopus 로고
    • N-terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation
    • Sasaki N.A., Garcia-Alvarez M.C., Wang Q., Ermolenko L., Franck G., Nhiri N., Martin M.T., Audic N., Potier P. N-terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation. Bioorg. Med. Chem. 2009, 17(6):2310-2320.
    • (2009) Bioorg. Med. Chem. , vol.17 , Issue.6 , pp. 2310-2320
    • Sasaki, N.A.1    Garcia-Alvarez, M.C.2    Wang, Q.3    Ermolenko, L.4    Franck, G.5    Nhiri, N.6    Martin, M.T.7    Audic, N.8    Potier, P.9
  • 42
    • 36749104186 scopus 로고    scopus 로고
    • In parkinsonian substantia nigra, A-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity
    • Shamoto-Nagai M., Maruyama W., Hashizume Y., Yoshida M., Osawa T., Riederer P., Naoi M. In parkinsonian substantia nigra, A-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proteasome activity. J. Neural Transm. 2007, 114:1559-1567.
    • (2007) J. Neural Transm. , vol.114 , pp. 1559-1567
    • Shamoto-Nagai, M.1    Maruyama, W.2    Hashizume, Y.3    Yoshida, M.4    Osawa, T.5    Riederer, P.6    Naoi, M.7
  • 44
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers-implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza J.M., Giasson B.I., Chen Q.P., Lee V.M.Y., Ischiropoulos H. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers-implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 2000, 275(24):18344-18349.
    • (2000) J. Biol. Chem. , vol.275 , Issue.24 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.P.3    Lee, V.M.Y.4    Ischiropoulos, H.5
  • 45
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U.S.A. 1998, 95(11):6469-6473.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , Issue.11 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 46
    • 0242666359 scopus 로고    scopus 로고
    • Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
    • Tofaris G.K., Razzaq A., Ghetti B., Lilley K.S., Spillantini M.G. Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J. Biol. Chem. 2003, 278(45):44405-44411.
    • (2003) J. Biol. Chem. , vol.278 , Issue.45 , pp. 44405-44411
    • Tofaris, G.K.1    Razzaq, A.2    Ghetti, B.3    Lilley, K.S.4    Spillantini, M.G.5
  • 47
    • 34548620297 scopus 로고    scopus 로고
    • Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
    • Uversky V.N. Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J. Neurochem. 2007, 103(1):17-37.
    • (2007) J. Neurochem. , vol.103 , Issue.1 , pp. 17-37
    • Uversky, V.N.1
  • 49
    • 0033938744 scopus 로고    scopus 로고
    • Quantitative structure-activity relationships for the toxicity to the tadpole Rana japonica of selected phenols
    • Wang X., Dong Y., Xu S., Wang L., Han S. Quantitative structure-activity relationships for the toxicity to the tadpole Rana japonica of selected phenols. Bull. Environ. Contam. Toxicol. 2000, 64(6):859-865.
    • (2000) Bull. Environ. Contam. Toxicol. , vol.64 , Issue.6 , pp. 859-865
    • Wang, X.1    Dong, Y.2    Xu, S.3    Wang, L.4    Han, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.