Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Cancer Biology and Therapy

Volumn 12, Issue 5, 2011, Pages 427-435

  Heakal, Yasser ^a,b   Woll, Matthew P ^a   Fox, Todd ^a   Seaton, Kelly ^a   Levenson, Robert ^a   Kester, Mark ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

G protein coupled receptor; Glycosylation; Lipid rafts; Neurotensin; Palmitoylation

Indexed keywords

2 BROMOPALMITIC ACID; CASPASE 3; CASPASE 7; CAVEOLIN; CYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; NEUROTENSIN; NEUROTENSIN RECEPTOR; NEUROTENSIN RECEPTOR 1; TUNICAMYCIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CELL MEMBRANE; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GLYCOSYLATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; PALMITOYLATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STARVATION; STRUCTURED MEMBRANE MICRODOMAIN;

APOPTOSIS; BREAST NEOPLASMS; CELL LINE; CELL MEMBRANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GLYCOSYLATION; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; LIPOYLATION; MAP KINASE SIGNALING SYSTEM; MUTAGENESIS, SITE-DIRECTED; NEUROTENSIN; PALMITATES; PHOSPHORYLATION; RECEPTORS, MITOGEN; RECEPTORS, NEUROTENSIN; TUNICAMYCIN;

EID: 80052372651     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.12.5.15984     Document Type: Article

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