Novel plasminogen activator inhibitor-1-derived peptide protects against impairment of cerebrovasodilation after photothrombosis through inhibition of JNK MAPK

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 299, Issue 2, 2010, Pages

  Armstead, William M ^a   Riley, John ^a   Kiessling, J Willis ^a   Cines, Douglas B ^a   Higazi, Abd Al Roof ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Cerebral circulation; Newborn; Plasminogen activators; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALTEPLASE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ENZYME INHIBITOR; OXYGEN; PLASMINOGEN ACTIVATOR INHIBITOR 1 DERIVED PEPTIDE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN; BRAIN CIRCULATION; CEREBROSPINAL FLUID; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; HYPERCAPNIA; HYPOTENSION; MALE; NEWBORN; NONHUMAN; PHOTOTHROMBOSIS; PIA ARTERY; PRIORITY JOURNAL; RISK ASSESSMENT; SWINE; SYSTEMATIC REVIEW; THROMBOSIS; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; ANTHRACENES; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; ERYTHROSINE; FEMALE; FIBRINOLYTIC AGENTS; IMIDAZOLES; INTRACRANIAL THROMBOSIS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LASERS, SOLID-STATE; MALE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDES; PROTEIN KINASE INHIBITORS; PYRIDINES; RECOMBINANT PROTEINS; SWINE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; VASOCONSTRICTION; VASODILATION;

EID: 77955488913     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00256.2010     Document Type: Article

References (22)

1. Akkawi S, Nassar T, Tarshis M, Cines DB, Higazi AAR. LRP and avB3 mediate tPA- activation of smooth muscle cells. Am J Physiol Heart Circ Physiol 291: H1351-H1359, 2006.
2. Armstead WM, Cines DB, Bdeir K, Kulikovskaya I, Stein SC, Higazi AAR. uPA impairs cerebrovasodilation after hypoxia/ischemia through LRP and ERK MAPK. Brain Res 1231: 121-131, 2008.
3. Armstead WM, Cines DB, Higazi AA. Plasminogen activators contribute to impairment of hypercapnic and hypotensive cerebrovasodilation after cerebral hypoxia/ischemia in the newborn pig. Stroke 36: 2265-2269, 2005.
4. Armstead WM, Cines DB, Higazi AAR. Plasminogen activators contribute to age dependent impairment of NMDA cerebrovasodilation after brain injury. Dev Brain Res 156: 139-146, 2005.
5. Armstead WM, Nassar T, Akkawi S, Smith DH, Chen XH, Cines DB, Higazi AAR. Neutralizing the neurotoxic effects of exogenous and endogenous tPA. Nat Neurosci 9: 1150-1157, 2006.
6. Borsello T, Clarke PGH, Hirt L, Vercelli A, Repici M, Schorderet DF, Bogousslavsky J, Bonny C. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med 9: 1180-1186, 2003.
7. Bu G, Wjilliams S, Strickland DR, Schwartz AL. Low density lipoprotein receptor-related protein/α2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator. Proc Natl Acad Sci USA 89: 7427-7431, 1992.
8. Dobbing J. The later growth of the brain and its vulnerability. Pediatrics 53: 2-6, 1974.
9. Fanne RA, Nassar T, Yarovoi S, Rayan A, Lamensdorf I, Cines DB, Higazi AAR. Bloodbrain barrier permeability and tPA-mediated neurotoxicity. Neuropharm 58: 972-980, 2010.
10. Janjua N, Nasar A, Lynch JK, Qureshi AI. Thrombolysis for ischemic stroke in children. Data from the nationwide inpatient sample. Stroke 38: 1850-1854, 2007.
11. Kuluz JW, Prado R, He D, Zhao W, Dietrich WD, Watson B. New pediatric model of ischemic stroke in infant piglets by photothrombosis. Stroke 38: 1932-1937, 2007.
12. Laher I, Zhang JH. Protein kinase C and cerebral vasospasm. J Cereb Blood Flow Metab 21: 887-906, 2001.
13. Nassar T, Akkawi S, Shin A, Haj-Yehia A, Bdeir Tarshis M K, Heyman SN, Higazi AA. In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone. Blood 103: 897-202, 2004.
14. Nassar T, Haj-Yehia A, Akkawi S, Kuo A, Bdeir K, Mazar A, Cines DB, Higazi AA. Binding of urokinase to low density lipoprotein-related receptor (LRP) regulates vascular smooth muscle cell contraction. J Biol Chem 277: 40499-404504, 2002.
15. Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie ET, Vivien D, Buisson A. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med 7: 59-64, 2001.
16. Rogove AD, Siao C, Keyt B, Strickland S, Tsirka SE. Activation of microglia reveals a non-proteolytic cytokine function for tissue plasminogen activator in the central nervous system. J Cell Sci 112: 4007-4016, 1999.
17. Shaver EG, Duhaime AC, Curtis M, Gennarelli LM, Barrett R. Experimental acute subdural hematoma in infant piglets. Pediatr Neurol 125: 123-129, 1996.
18. Tan Z, Li X, Kelly k Rosen C, Huber J. Plasminogen activator inhibitor type I derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion. Brain Res 1281: 84-90, 2009.
19. Tsirka SE, Gualandris A, Amaral DG, Strickland S. Excitotoxininduced neuronal degeneration and seizure are mediated by tissue plasminogen activator. Nature 377: 340-344, 1995.
20. Yepes M, Sandkvist M, Moore EG, Bugge TH, Strickland DS, Lawrence DA. Tissue-type plasminogen activator induces opening of the blood brain barrier via the LDL receptor-related protein. J Clin Invest 112: 1533-1540, 2003.
21. Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-29 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma 19: 615-625, 2002.
22. Wang YF, Tsirka SE, Strickland S, Stiege PE, Lipton SA. Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild type and tPA-deficient mice. Nat Med 4: 228-231, 1998.