Improved functional vasodilation in obese Zucker rats following exercise training

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 3, 2011, Pages

  Sebai, Mohamad ^a   Lu, Silu ^a   Xiang, Lusha ^a   Hester, Robert L ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Functional vasodilation; Insulin resistance; Thromboxane

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ARACHIDONIC ACID; THROMBOXANE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTICLE; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; CREMASTER MUSCLE; EXERCISE INTENSITY; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; TRAPEZIUS MUSCLE; TREADMILL EXERCISE; VASOCONSTRICTION; VASODILATATION;

ANALYSIS OF VARIANCE; ANIMALS; ARACHIDONIC ACID; BLOOD GLUCOSE; BODY WEIGHT; DISEASE MODELS, ANIMAL; EATING; ELECTRIC STIMULATION; EXERCISE THERAPY; GLUCOSE TOLERANCE TEST; HYDRAZINES; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; OBESITY, MORBID; OXYGEN CONSUMPTION; RATS; RATS, ZUCKER; RECEPTORS, THROMBOXANE; RECOVERY OF FUNCTION; TIME FACTORS; VASOCONSTRICTION; VASODILATION;

EID: 80052336557     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00233.2011     Document Type: Article

References (49)

1. Banks EA, Brozinick JT Jr, Yaspelkis BB III, Kang HY, Ivy JL. Muscle glucose transport, GLUT-4 content, and degree of exercise training in obese Zucker rats. Am J Physiol Endocrinol Metab 263: E1010-E1015, 1992.
2. Beckman JA, Goldfine AB, Gordon MB, Creager MA. Ascorbate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans. Circulation 103: 1618-1623, 2001.
3. Bradley SJ, Kingwell BA, Canny BJ, McConell GK. Skeletal muscle neuronal nitric oxide synthase micro protein is reduced in people with impaired glucose homeostasis and is not normalized by exercise training. Metabolism 56: 1405-1411, 2007.
4. Brozinick JT Jr, Etgen GJ Jr, Yaspelkis BB III, Kang HY, Ivy JL. Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats. Am J Physiol Endocrinol Metab 265: E419-E427, 1993.
5. Burstein R, Zissholtz A, Zick-Bachar Y, Epstein Y, Shapiro Y, Karnieli E. Glucose uptake by adipocytes of obese rats: effect of one bout of acute exercise. Can J Physiol Pharmacol 70: 1473-1476, 1992.
6. Duscha BD, Kraus WE, Keteyian SJ, Sullivan MJ, Green HJ, Schachat FH, Pippen AM, Brawner CA, Blank JM, Annex BH. Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations. J Am Coll Cardiol 33: 1956-1963, 1999.
7. Etgen GJ Jr, Jensen J, Wilson CM, Hunt DG, Cushman SW, Ivy JL. Exercise training reverses insulin resistance in muscle by enhanced recruitment of GLUT-4 to the cell surface. Am J Physiol Endocrinol Metab 272: E864-E869, 1997.
8. Fossum E, Hoieggen A, Moan A, Rostrup M, Nordby G, Kjeldsen SE. Relationship between insulin sensitivity and maximal forearm blood flow in young men. Hypertension 32: 838-843, 1998.
9. Frandsen U, Bangsbo J, Langberg H, Saltin B, Hellsten Y. Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. J Vasc Res 37: 297-302, 2000.
10. Frisbee JC. Impaired skeletal muscle perfusion in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 285: R1124-R1134, 2003.
11. Frisbee JC, Samora JB, Peterson J, Bryner R. Exercise training blunts microvascular rarefaction in the metabolic syndrome. Am J Physiol Heart Circ Physiol 291: H2483-H2492, 2006.
12. Gordon MB, Jain R, Beckman JA, Creager MA. The contribution of nitric oxide to exercise hyperemia in the human forearm. Vasc Med 7: 163-168, 2002.
13. Gray SD. Rat spinotrapezius muscle preparation for microscopic observation of the terminal vascular bed. Microvasc Res 5: 395-400, 1973.
14. Grijalva J, Hicks S, Zhao X, Medikayala S, Kaminski PM, Wolin MS, Edwards JG. Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. Cardiovasc Diabetol 7: 34, 2008.
15. Gryglewski RJ, Botting RM, Vane JR. Mediators produced by the endothelial cell. Hypertension 12: 530-548, 1988.
16. Hammer LW, Ligon AL, Hester RL. ATP-mediated release of arachidonic acid metabolites from venular endothelium causes arteriolar dilation. Am J Physiol Heart Circ Physiol 280: H2616-H2622, 2001.
17. Hansen D, Dendale P, van Loon LJ, Meeusen R. The impact of training modalities on the clinical benefits of exercise intervention in patients with cardiovascular disease risk or type 2 diabetes mellitus. Sports Med 40: 921-940, 2010.
18. Heath GW, Brown DW. Recommended levels of physical activity and health-related quality of life among overweight and obese adults in the United States, 2005. J Phys Act Health 6: 403-411, 2009.
19. Henriksen EJ. Invited review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93: 788-796, 2002.
20. Hodnett BL, Dearman JA, Carter CB, Hester RL. Attenuated PGI2 synthesis in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 296: R715-R721, 2009.
21. Hodnett BL, Xiang L, Dearman JA, Carter CB, Hester RL. K(ATP)-mediated vasodilation is impaired in obese Zucker rats. Microcirculation 15: 485-494, 2008.
22. Ishizuka T, Matsui T, Kurita A. Ramatroban, a TP receptor antagonist, improves vascular responses to acetylcholine in hypercholesterolemic rabbits in vivo. Eur J Pharmacol 468: 27-35, 2003.
23. Kalani M. The importance of endothelin-1 for microvascular dysfunction in diabetes. Vasc Health Risk Manag 4: 1061-1068, 2008.
24. Karamouzis M, Karamouzis I, Vamvakoudis E, Ampatzidis G, Christoulas K, Angelopoulou N, Mandroukas K. The response of muscle interstitial prostaglandin E2 (PGE2), prostacyclin I2 (PGI2) and thromboxane A2 (TXA2) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. Prostaglandins Leukot Essent Fatty Acids 64: 259-263, 2001.
25. Kim SH, Park KW, Kim YS, Oh S, Chae IH, Kim HS, Kim CH. Effects of acute hyperglycemia on endothelium-dependent vasodilation in patients with diabetes mellitus or impaired glucose metabolism. Endothelium 10: 65-70, 2003.
26. Klumpp G, Schildknecht S, Nastainczyk W, Ullrich V, Bachschmid M. Prostacyclin in the cardiovascular system: new aspects and open questions. Pharmacol Rep 57, Suppl: 120-126, 2005.
27. Komers R, Zdychova J, Cahova M, Kazdova L, Lindsley JN, Anderson S. Renal cyclooxygenase-2 in obese Zucker (fatty) rats. Kidney Int 67: 2151-2158, 2005.
28. McKay MK, Gardner AL, Boyd D, Hester RL. Influence of venular prostaglandin release on arteriolar diameter during functional hyperemia. Hypertension 31: 213-217, 1998.
29. McLennan IS, Macdonald RE. Prostaglandin synthetase and prostacyclin synthetase in mature rat skeletal muscles: immunohistochemical localisation to arterioles, tendons and connective tissues. J Anat 178: 243-253, 1991.
30. Murrant CL, Duza T, Kim MB, Cohen KD, Sarelius IH. Arteriolar dilations induced by contraction of hamster cremaster muscle are dependent on changes in endothelial cell calcium. Acta Physiol Scand 180: 231-238, 2004.
31. Naik JS, Xiang L, Hester RL. Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 290: R154-R161, 2006.
32. Nuttle LC, Ligon AL, Farrell KR, Hester RL. Inhibition of phospholipase A2 attenuates functional hyperemia in the hamster cremaster muscle. Am J Physiol Heart Circ Physiol 276: H1289-H1294, 1999.
33. Quilley J, McGiff JC. Renal vascular responsiveness to arachidonic acid in experimental diabetes. Br J Pharmacol 100: 336-340, 1990.
34. Saito Y, Eraslan A, Lockard V, Hester RL. Role of venular endothelium in control of arteriolar diameter during functional hyperemia. Am J Physiol Heart Circ Physiol 267: H1227-H1231, 1994.
35. Sothern MS. Exercise as a modality in the treatment of childhood obesity. Pediatr Clin North Am 48: 995-1015, 2001.
36. Tominaga M, Eguchi H, Manaka H, Igarashi K, Kato T, Sekikawa A. Impaired glucose tolerance is a risk factor for cardiovascular disease, but not impaired fasting glucose. The Funagata Diabetes Study. Diabetes Care 22: 920-924, 1999.
37. Vitale C, Mercuro G, Cornoldi A, Fini M, Volterrani M, Rosano GM. Metformin improves endothelial function in patients with metabolic syndrome. J Intern Med 258: 250-256, 2005.
38. Walberg JL. Aerobic exercise and resistance weight-training during weight reduction. Implications for obese persons and athletes. Sports Med 7: 343-356, 1989.
39. Wilmore JH, Costill DL. Physiology of Sport and Exercise (3rd Ed.). Champaign, IL: Human Kinetics, 2005.
40. Wojtaszewski JF, Nielsen JN, Richter EA. Invited review: Effect of acute exercise on insulin signaling and action in humans. J Appl Physiol 93: 384-392, 2002.
41. Xiang L, Dearman J, Abram SR, Carter C, Hester RL. Insulin resistance and impaired functional vasodilation in obese Zucker rats. Am J Physiol Heart Circ Physiol 294: H1658-H1666, 2008.
42. Xiang L, Naik J, Hester RL. Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 288: R987-R991, 2005.
43. Xiang L, Naik JS, Abram SR, Hester RL. Chronic hyperglycemia impairs functional vasodilation via increasing thromboxane-receptor-mediated vasoconstriction. Am J Physiol Heart Circ Physiol 292: H231-H236, 2007.
44. Xiang L, Naik JS, Hester RL. Functional vasodilation in the rat spinotrapezius muscle: role of nitric oxide, prostanoids and epoxyeicosatrienoic acids. Clin Exp Pharmacol Physiol 35: 617-624, 2008.
45. Xiang L, Naik JS, Hodnett BL, Hester RL. Altered arachidonic acid metabolism impairs functional vasodilation in metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 290: R134-R138, 2006.
46. Yamada M, Omata K, Abe F, Ito S, Abe K. Changes in prostacyclin, thromboxane A2 and F2-isoprostanes, and influence of eicosapentaenoic acid and antiplatelet agents in patients with hypertension and hyperlipidemia. Immunopharmacology 44: 193-198, 1999.
47. Yu H, Gallagher AM, Garfin PM, Printz MP. Prostacyclin release by rat cardiac fibroblasts: inhibition of collagen expression. Hypertension 30: 1047-1053, 1997.
48. Zoladz JA, Majerczak J, Duda K, Chlopicki S. Exercise-induced prostacyclin release positively correlates with VO(2max) in young healthy men. Physiol Res 58: 229-238, 2009.
49. Zou MH, Shi C, Cohen RA. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes 51: 198-203, 2002.