Exercise-induced prostacyclin release positively correlates with Vo2max in young healthy men

Physiological Research

Volumn 58, Issue 2, 2009, Pages 229-238

  Zoladz, J A ^a   Majerczak, J ^a   Duda, K ^a,b   Chlopicki S ^c  

^a UNIVERSITY OF PHYSICAL EDUCATION   (Poland)

^b Cancer Institute   (Poland)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Exercise; Maximal oxygen uptake; Power output; Prostacyclin

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; INTERLEUKIN 10; INTERLEUKIN 6; LACTIC ACID; PROSTACYCLIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD; EXERCISE; EXERCISE TEST; HEART RATE; HUMAN; LUNG VENTILATION; MALE; OXYGEN CONSUMPTION; PHYSIOLOGY; REST;

6-KETOPROSTAGLANDIN F1 ALPHA; EPOPROSTENOL; EXERCISE; EXERCISE TEST; HEART RATE; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; LACTIC ACID; MALE; OXYGEN CONSUMPTION; PULMONARY VENTILATION; REST; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 66349128547     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. Andersen P, Saltin B: Maximal perfusion of skeletal muscle in man. J Physiol Lond 366: 233-249, 1985.
2. Barrow SE, Dollery CT, Heavey DJ, Hickling NE, Ritter JM, VIAL J: Effect of vasoactive peptides on prostacyclin synthesis in man. Br J Pharmacol 87: 243-247, 1986.
3. Bartsch P: Platelet activation with exercise and risk of cardiac events. Lancet 354: 1747-1748, 1999.
4. Bassett DT, Holewy ET: Limiting factors for maximum oxygen uptake and determinants of endurance performance. Med Sci Sports Exerc 32: 70-84, 2000.
5. Blumberg FC, Riegger GA, Pfeifer M: Hemodynamic effects of aerosolized iloprost in pulmonary hypertension at rest and during exercise. Chest 121: 1566-1571, 2002.
6. Boger RH, Bode-Boger SM, Schroder EP, Tsikas D, Frolich JC: Increased prostacyclin production during exercise in untrained and trained men: effect of low-dose aspirin. J Appl Physiol 78: 1832-1838, 1995.
7. Bonetti PO, Lerman LO, Lerman A: Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23: 168-175, 2003.
8. Boushel R, Langberg H, Olesen J, Nowak M, Simonsen L, Bulow J, Kjaer M: Regional blood flow during exercise in humans measured by near-infrared spectroscopy and indocyanine green. J Appl Physiol 89: 1868-1878, 2000.
9. Bugiardini R, Galvani M, Ferrini D, Gridelli C, Mari L, Puddu P, Lenzi S: Effects of iloprost, a stable prostacyclin analog, on exercise capacity and platelet aggregation in stable angina pectoris. Am J Cardiol 58: 453-459, 1986.
10. Chlopicki S, Gryglewski RJ: Angiotensin converting enzyme (ACE) and HydroxyMethylGlutaryl-CoA (HMGCoA) reductase inhibitors in the forefront of pharmacology of endothelium. Pharmacol Rep 57: 86-96, 2005.
11. Ciuffetti G, Sokola E, Lombardini R, Pasqualini L, Pirro M, Mannarino E: The influence of iloprost on blood rheology and tissue perfusion in patients with intermittent claudication. Kardiol Pol 59: 197-204, 2003.
12. Dowd NP, Scully M, Adderley SR, Cunningham AJ, Fitzgerald DJ: Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo. J Clin Invest 108: 585-590, 2001.
13. Feng DL, Murillo J, Jadhav P, Mckenna C, Gebara OC, Lipinska I, Muller JE, Tofler GH: Upright posture and maximal exercise increase platelet aggregability and prostacyclin production in healthy male subjects. Br J Sports Med 33: 401-404, 1999.
14. Frandsen U, Bangsbo J, Langberg H, Saltin B, Hellsten Y: Inhibition of nitric oxide synthesis by systemic N(G)-monomethyl-L-arginine administration in humans: effects on interstitial adenosine, prostacyclin and potassium concentrations in resting and contracting skeletal muscle. J Vasc Res 37: 297-302, 2000.
15. Green DJ, Maiorana A, O'driscoll G, Taylor R: Effect of exercise training on endothelium-derived nitric oxide function in humans. J Physiol Lond 561: 1-25, 2004.
16. Grosser T, Fries S, Fitzgerald GA: Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest 116: 4-15, 2006.
17. Gryglewski RJ: Prostaglandins, platelets, and atherosclerosis. CRC Crit Rev Biochem 7: 291-338, 1980a.
18. Gryglewski RJ: The lung as a generator of prostacyclin. CIBA Found Symp 78: 147-164, 1980b.
19. Gryglewski RJ, Moncada S, Palmer RM: Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells. Br J Pharmacol 87: 685-694, 1986.
20. Gryglewski RJ, Botting RM, Vane JR: Mediators produced by the endothelial cell. Hypertension 12: 530-548, 1988.
21. Hill LL, Pearl RG: Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension. J Appl Physiol 86: 1160-1164, 1999.
22. 2) levels during incremental dynamic exercise in humans determined by in vivo microdialysis. Prostaglandins Leukot Essent Fatty Acids 64: 259-263, 2001.
23. Kestin AS, Ellis PA, Barnard MR, Errichetti A, Rosner BA, Michelson AD: Effect of strenuous exercise on platelet activation state and reactivity. Circulation 88: 1502-1511, 1993.
24. Kishi Y, Ashikaga T, Numano F: Inhibition of platelet aggregation by prostacyclin is attenuated after exercise in patients with angina pectoris. Am Heart J 123: 291-297, 1992.
25. Kjaer M, Magnusson P, Krogsgaard M, Boysen Moller J, Olesen J, Heinemeier K, Hansen M, Haraldsson B, Koskinen S, Esmarck B, Langberg H: Extracellular matrix adaptation of tendon and skeletal muscle to exercise. J Anat 208: 445-450, 2006.
26. Koivisto VA, Jantunen M, Sane T, Helve E, Pelkonen R, Viinikka L, Ylikorkala O: Stimulation of prostacyclin synthesis by physical exercise in type I diabetes. Diabetes Care 12: 609-614, 1989.
27. Lang CC, Chomsky DB, Butler J, Kapoor S, Wilson JR: Prostaglandin production contributes to exerciseinduced vasodilation in heart failure. J Appl Physiol 83: 1933-1940, 1997.
28. Langberg H, Bjorn C, Boushel R, Hellsten Y, Kjaer M: Exercise-induced increase in interstitial bradykinin and adenosine concentrations in skeletal muscle and peritendinous tissue in humans. J Physiol Lond 542: 977-983, 2002.
29. Li N, He S, Blomback M, Hjemdahl P: Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin. Arterioscler Thromb Vasc Biol 27: 407-413, 2007.
30. Mclennan IS, Macdonald RE: Prostaglandin synthetase and prostacyclin synthetase in mature rat skeletal muscles: immunohistochemical localisation to arterioles, tendons and connective tissues. J Anat 178: 243-253, 1991.
31. Mehta J, Mehta P, Horalek C: The significance of platelet-vessel wall prostaglandin equilibrium during exercise-induced stress. Am Heart J 105: 895-900, 1983.
32. Merkus D, Houweling B, Zarbanoui A, Duncker DJ: Interaction between prostanoids and nitric oxide in regulation of systemic, pulmonary, and coronary vascular tone in exercising swine. Am J Physiol 286: H1114-H1123, 2004.
33. Merkus D, Sorop O, Houweling B, Boomsma F, van Den Meiracker AH, Duncker DJ: NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine. Am J Physiol 291: H2075-H2081, 2006.
34. Middlekauff HR, Chiu J: Cyclooxygenase products sensitize muscle mechanoreceptors in healthy humans. Am J Physiol 287: H1944-H1949, 2004.
35. Moore KP, Sheron N, Ward P, Taylor GW, Alexander GJ, Williams R: Leukotriene and prostaglandin production after infusion of tumour necrosis factor in man. Eicosanoids 4: 115-118, 1991.
36. Muller B, Krais T, Sturzebecher S, Witt W, Schillinger E, Baldus B: Potential therapeutic mechanisms of stable prostacyclin (PGI2)-mimetics in severe peripheral vascular disease. Biomed Biochim Acta 47: S40-S44, 1988.
37. Nosaka S, Hashimoto M, Sasaki T, Ku K, Saitoh Y, Yamauchi M, Tanabe Y, Nakaki T, Hishikawa K, Masumura S, Nakayama K, Tamura K: The effects of transmural pressure on prostacyclin release from porcine endocardial endothelial cells - comparison with vascular endothelial cells. Pflugers Arch 433: 848-850, 1997.
38. Pasqualini L, Pirro M, Lombardini R, Ciuffetti G, Dragani P, Mannarino E: A human model of platelet-leucocyte adhesive interactions during controlled ischaemia in patients with peripheral vascular disease. J Clin Pathol 55: 946-950, 2002.
39. Raczka E, Quintana A: Effects of intravenous administration of prostacyclin on regional blood circulation in awake rats. Br J Pharmacol 126: 1325-1332, 1999.
40. Rasmanis G, Vesterqvist O, Green K, Edhag O, Henriksson P: Prostacyclin production in myocardial infarction in the acute phase and during follow-up. J Intern Med 229: 135-141, 1991.
41. Richardson RS, Saltin B: Human muscle blood flow and metabolism studied in the isolated quadriceps muscles. Med Sci Sports Exerc 30: 28-33, 1998.
42. Ritter JM, Barrow SE, Blair IA, Dollery CT: Release of prostacyclin in vivo and its role in man. Lancet 1: 317-319, 1983.
43. Rocca GD, Coccia C, Pompei L, Ruberto F, Venuta F, de Giacomo T, Pietropaoli P: Hemodynamic and oxygenation changes of combined therapy with inhaled nitric oxide and inhaled aerosolized prostacyclin. J Cardiothorac Vasc Anesth 15: 224-227, 2001.
44. Ronni-Sivula H, Malm H, Ylikorkala O, Viinikka L: Marathon run stimulates more prostacyclin than thromboxane synthesis and differently in men and women. Prostaglandins 46: 75-79, 1993.
45. Saltin B, Calbet JA: Point: in health and in a normoxic environment, VO2max is limited primarily by cardiac output and locomotor muscle blood flow. J Appl Physiol 100: 744-745, 2006.
46. Sakuma T, Zhao Y, Sugita M, Sagawa M, Hida M, TOGA H: A prostacyclin analogue, OP-41483alpha-CD, restores the ability of a beta2-adrenergic agonist to stimulate alveolar fluid clearance in rats. Surg Today 34: 429-436, 2004.
47. Saunders NR, Dinenno FA, Pyke KE, Rogers AM, Tschakovsky ME: Impact of combined NO and PG blockade on rapid vasodilation in a forearm mild-to-moderate exercise transition in humans. Am J Physiol Heart Circ Physiol 288: H214-H220, 2005.
48. Schildknecht S, Bachschmid M, Weber K, Maass D, Ullrich V: Endotoxin elicits nitric oxide release in rat but prostacyclin synthesis in human and bovine vascular smooth muscle cells. Biochem Biophys Res Commun 327: 43-48, 2005.
49. Schrage WG, Joyner MJ, Dinenno FA: Local inhibition of nitric oxide and prostaglandins independently reduces forearm exercise hyperaemia in humans. J Physiol Lond 557: 599-611, 2004.
50. Schrage WG, Eisenach JH, Joyner MJ: Ageing reduces nitric-oxide- and prostaglandin-mediated vasodilatation in exercising humans. J Physiol Lond 579: 227-236, 2007.
51. Sprague RS, Olearczyk JJ, Spence DM, Stephenson AH, Sprung RW, Lonigro AJ: Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol 285: H693-H700, 2003.
52. Sprague R, Bowles E, Stumpf M, Ricketts G, Freidman A, Hou WH, Stephenson A, Lonigro A: Rabbit erythrocytes possess adenylyl cyclase type II that is activated by the heterotrimeric G proteins Gs and Gi. Pharmacol Rep 57: 222-228, 2005.
53. Streiff M, Bell WR: Exercise and hemostasis in humans. Semin Hematol 31: 155-165, 1994.
54. Vanhoutte PM: Ageing and endothelial dysfunction. Eur Heart J 4: A8-A17, 2002.
55. Wax D, Garofano R, Barst RJ: Effects of long-term infusion of prostacyclin on exercise performance in patients with primary pulmonary hypertension. Chest 116: 914-920, 1999.
56. 2 and prostacyclin metabolites before and after exercise testing in patients with and without signs of ischemic heart disease. Circulation 82: 1737-1743, 1990.
57. Wensel R, Opitz CF, Ewert R, Bruch L, Kleber FX: Effects of iloprost inhalation on exercise capacity and ventilatory efficiency in patients with primary pulmonary hypertension. Circulation 101: 2388-2392, 2000.
58. Woodman CR, Thompson MA, Turk JR, Laughlin MH: Endurance exercise training improves endotheliumdependent relaxation in brachial arteries from hypercholesterolemic male pigs. J Appl Physiol 99: 1412-1421, 2005.
59. Yu H, Gallagher AM, Garfin PM, Printz MP: Prostacyclin release by rat cardiac fibroblasts: inhibition of collagen expression. Hypertension 30: 1047-1053, 1997.
60. 2 uptake and power output at high intensities of exercise in humans. J Physiol Lond 488: 211-217, 1995.
61. Zoladz JA, Duda K, Majerczak J: Oxygen uptake does not increase linearly at high power outputs during incremental exercise test in humans. Eur J Appl Physiol 77: 445-451, 1998.